Construction of preventive approaches in pediatric dentistry field for inflammatory bowel diseases caused by oral bacteri

儿童口腔领域口腔细菌引起的炎症性肠病预防途径构建

• 批准号: 24890123
• 负责人: URATA Ayuchi
• 金额: $ 1.83万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-08-31 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24890123/
• 关键词: 口腔細菌; 炎症性腸疾患; IFN-γ; サイトカイン; マウスモデル; 中和抗体; 炎症性腸炎; IFN- γ; 感染性心内膜炎; 潰瘍性大腸炎; Streptococcus mutans; Streptococcus sanguinis; 中和抗

Streptococcus mutans, a major pathogen of dental caries, is known to invade the bloodstream and sometimes causes systemic diseases. The present study investigated the possible mechanism of aggravation of inflammatory bowel diseases caused by S. mutans. We found that hepatocytes invaded by S. mutans produced IFN-gamma, while alpha-AGP and amyloid A1 enhanced inflammation and unbalanced the immune system, leading to aggravation of inflammatory bowel diseases. In addition, it was shown that the neutralizing antibody against IFN-gamma improved the condition.

变形链球菌是龋齿的主要病原体，它会侵入血液，有时会引起全身性疾病。本研究探讨了变形链球菌引起炎症性肠病加重的可能机制。我们发现被变形链球菌入侵的肝细胞产生ifn - γ，而α - agp和淀粉样蛋白A1增强炎症并使免疫系统失衡，导致炎症性肠病加重。此外，研究表明，抗ifn - γ的中和抗体改善了这种情况。

项目成果

Aggravation of inflammatory bowel diseases by oral streptococci

• DOI: 10.1111/odi.12125
• 发表时间: 2014-05-01
• 期刊: ORAL DISEASES
• 影响因子: 3.8
• 作者: Kojima, A.;Nomura, R.;Nakano, K.
• 通讯作者: Nakano, K.

Infection of specific strains of Streptococcus mutans, oral bacteria, confers a risk of ulcerative colitis.

• DOI: 10.1038/srep00332
• 发表时间: 2012
• 期刊: SCIENTIFIC REPORTS
• 影响因子: 4.6
• 作者: Kojima, Ayuchi;Nakano, Kazuhiko;Wada, Koichiro;Takahashi, Hirokazu;Katayama, Kazufumi;Yoneda, Masato;Higurashi, Takuma;Nomura, Ryota;Hokamura, Kazuya;Muranaka, Yoshinori;Matsuhashi, Nobuyuki;Umemura, Kazuo;Kamisaki, Yoshinori;Nakajima, Atsushi;Ooshima, Takashi
• 通讯作者: Ooshima, Takashi

Aggravation of inflammatory bowel diseases by Streptococcus sanguinis.

血链球菌加重炎症性肠病。

• 发表时间: 2013
• 作者: Kojima A;Nomura R;Ooshima T;Nakano K.
• 通讯作者: Nakano K.

Streptococcus mutansの引き起こす腸炎悪化におけるIFN- γ の役割に対する分析

IFN-γ在变形链球菌肠炎加重中的作用分析

• 发表时间: 2012
• 作者: 小島あゆち;仲野和彦;野村良太;大嶋隆
• 通讯作者: 大嶋隆

Streptococcus mutansが誘発する腸炎悪化メカニズムの解析

变形链球菌引起肠道炎症加重的机制分析

• 发表时间: 2013
• 作者: Kojima A;Nakano K;Wada K;Takahashi H;Katayama K;Yoneda M;Higurashi T;Nomura R;Hokamura K;Muranaka Y;Matsuhashi N;Umemura K;Kamisaki Y;Nakajima A;Ooshima T;小島あゆち;小島あゆち
• 通讯作者: 小島あゆち