Construction of preventive approaches in pediatric dentistry field for inflammatory bowel diseases caused by oral bacteri

变形链球菌是龋齿的主要病原体，已知会侵入血液，有时会导致全身疾病。本研究探讨了变形链球菌引起炎症性肠病加重的可能机制。我们发现变形链球菌侵袭的肝细胞产生干扰素-γ，而α-AGP和淀粉样蛋白A1促进炎症和免疫系统失衡，导致炎症性肠病的加重。此外，干扰素-γ的中和抗体也改善了这一状况。

Streptococcus mutans, a major pathogen of dental caries, is known to invade the bloodstream and sometimes causes systemic diseases. The present study investigated the possible mechanism of aggravation of inflammatory bowel diseases caused by S. mutans. We found that hepatocytes invaded by S. mutans produced IFN-gamma, while alpha-AGP and amyloid A1 enhanced inflammation and unbalanced the immune system, leading to aggravation of inflammatory bowel diseases. In addition, it was shown that the neutralizing antibody against IFN-gamma improved the condition.