Involvement of periodontal ligament cells in angiogenesis induced by FGF-2

在这项研究中，我们研究了FGF-2是否可以诱导血管内皮生长因子(VEGF)-A在牙周韧带（PDL）细胞中的表达，以及PDL细胞和内皮细胞（EC）之间的细胞间相互作用是否可以刺激血管生成。FGF-2诱导PDL细胞表达VEGF-A。FGF-2和VEGF-A协同刺激PDL细胞的迁移。延时分析显示PDL细胞迁移到管状EC附近，模仿周细胞。这些发现表明，FGF-2和FGF-2诱导的VEGF-A，以及PDL细胞和EC之间的细胞间相互作用，通过在FGF-2应用的部位协调血管生成，创造了一个合适的牙周再生环境。

In this study, we examined whether FGF-2 could induce vascular endothelial growth factor (VEGF)-A expression in periodontal ligament (PDL) cells and whether cell-to-cell interaction between PDL cells and endothelial cells (EC) could stimulate angiogenesis. FGF-2 induced VEGF-A expression from PDL cells. FGF-2 and VEGF-A synergistically stimulated the migration of PDL cells. Time-lapse analysis revealed that PDL cells migrated close to the tube-forming EC, mimicking pericytes. These findings suggest that FGF-2 and FGF-2-induced VEGF-A, as well as cell-to-cell interactions between PDL cells and EC, create a suitable environment of periodontal regeneration by orchestrating angiogenesis at FGF-2-applied sites.