Age-related changes in peripheral circulatory function and in serum condition childhood and their relation to life styles

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This study was transversally undertaken to determine the changes of peripheral circulatory function and to clarity the changes of serum conditions through the use of Japanese students.When we analyze wave forms of accelerated plethysmography (APG) in adolescent, we have to exclude effects of increasing height resulting form growth. In this project, we evaluated the index of APG, d/a, with using the standard height-d/a curves, in order to exclude the effects of increasing height. We were, then, able to clarify the relation of d/a to variable risk factors of arthevosclerosis. Consequently, the standard height-d/a curves are useful tools for evaluating the preripheral circulatory function in adolescent, who are in growing stage, by the APG. 315 healthy children (170 girls and 145 boys), mean age, 13.6 years, in elementary, junior high and high school, were transversally studied. We performed blood pressure(BP) measurements by a sphygmomanometer and measured BMI, plasma NE, INS and LEP. Obesity was found ll subjects whose LEP were 16.6±13.3 ng/ml. INS were 16.2±7.5 μ/ml and total energy consumption were 2450±330 kcal. These were significantly higher than normal controls(p<0.001). Hypertensives were9 subjects and with body weight until 12 years. Boys always had lower LEP levels than girls. There was appositive correlation between LEP and BMI(r=0.38, p<0.001), diastolic(D)BP(r=0.14, p=0.009), INS(r=0.19, p<0.001). Stepwise logistic regression showed that MI(t=8.95), DBP(t=2.71)and INS(t=2.33)were significant correlation with LEP. These data suggest that in the children 1)obesity were found only 3.5%, whose leptin, insulin and consumption energy were extremely high and 2)leptin have a significant correlation with BMI and DBF.