Effect of Mild Exercise on Non-Insulin Mediated Glucose Uptake

轻度运动对非胰岛素介导的葡萄糖摄取的影响

• 批准号: 09480016
• 负责人: KIYONAGA Akira
• 金额: $ 2.62万
• 依托单位: Fukuoka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-09480016/
• 关键词: Exercise training; Insulin sensitivity; Minimal model; 簡易運動負荷テスト; 運動処方; 日常身体活動量; 糖尿病運動療法; 運動; 耐糖能; グルコースクランプ

1. The non-insulin mediated glucose uptake did not change 3 h after the single bout of exercise (15 m/min, 90 min, treadmill running). However, after 5-wk exercise training. (4day/wk, 15〜25 m/min, 60 min/day ), the non-insulin mediated glucose uptake significantly increased (Glucose infusion rate : Control 6.5±0.8, Exercise 8.5±1.5 mg/kg/min, p<0.01). 2. The effect of a single bout of mild exercise on glucose effectiveness (S_G) and insulin sensitivity (S_1) was studied in young men using a minimal model. After a bout of exercise on a cycle ergometer at the lactate threshold level for 60 min, S_1 did not significantly change, whereas the S_G significantly increased (0.016±0.002 vs. 0.025±0.002 min^<-1>, P<0.01). The increase in S^G immediately after a single bout of mild exercise is similar to the level in trained subjects. 3. Healthy men (18-25 yr.) were studied on S^G, before and after the ergometer training at lactate threshold intensity for 60 min/day, 5 days/wk for 6 weeks. The mild exercise training improves S_G, from 0.018±0.002 to 0.024±0.001 min^<-1> (P<0.05). S_1 also significantly increased after the training regimen (P<0.05). Improving not only S_1 but also S_G through mild exercise training is thus considered to be an effective method for preventing glucose intolerance. 4. We originated the step test using benches and walking test using small calorie counters for patients with diabetes. More than 90% of the cases, lactate threshold can be determined using these tests. Therefore, these simple exercise tests would be useful for evaluating aerobic capacity and making out exercise prescriptions for patients with diabetes.

1.非胰岛素介导的葡萄糖摄取在单次运动（15 m/min，90 min，跑台跑步）后3 h没有变化。然而，经过5周的运动训练。(4day/wk，15 ~ 25 m/min，60 min/d），非胰岛素介导的葡萄糖摄取显著增加（葡萄糖输注速率：对照组6.5±0.8，运动组8.5±1.5 mg/kg/min，p<0.01）。2.本文用最小模型研究了一次轻度运动对青年男性葡萄糖利用率（S_G）和胰岛素敏感性（S_1）的影响。在乳酸阈水平上踏车运动60 min后，S_1无明显变化，而S_G显著增加（0.016±0.002对0.025±0.002 min^<-1>，P&lt;0.01）。在一次轻度运动后，S^G的增加与受过训练的受试者的水平相似。3.健康男性（18-25岁）分别于乳酸阈强度60 min/d，5 d/wk，连续6周的功率机训练前后，测定大鼠的S^G。轻度运动训练使S_G从0.018±0.002提高到0.024±0.001 min^<-1>（P&lt;0.05）。S_1在训练后也显著增加（P&lt;0.05）。因此，通过轻度运动训练，不仅提高S_1，而且提高S_G，是预防糖耐量异常的有效方法。4.我们首先对糖尿病患者进行了长凳台阶试验和小卡路里计数器步行试验。超过90%的情况下，乳酸阈值可以使用这些测试来确定。因此，这些简单的运动测试将有助于评估有氧能力和制定运动处方的糖尿病患者。

项目成果

Yuichiro Nishida et.al.: "Effect of mild exercise training on glucose effectiveness in healthy men"Diabetes Care. (in press).

Yuichiro Nishida 等人：“轻度运动训练对健康男性血糖有效性的影响”糖尿病护理。

Yuichiro Nishida,Hiroaki Tanaka et al: "Effect of mild exercise training on glucose effectiveness in healthy men"Diabetes Care. (In press).

Yuichiro Nishida、Hiroaki Tanaka 等人：“轻度运动训练对健康男性血糖有效性的影响”糖尿病护理。

Makoto Sakamoto el.al.: "Influence of mild exercise at the lactate threshold on glucose effectiveness"Journal of Applied Physiology. 87(6). 2305-2310 (1999)

Makoto Sakamoto 等人：“乳酸阈值下的轻度运动对葡萄糖有效性的影响”应用生理学杂志。

Makoto Sakamoto et. al: "Influence of mild exercise at the lactate threshold on glucose effectiveness."J Appl Physiol. 87(6). 2305-2310 (1999)

坂本诚等。

Makoto Sakamoto,Hiroaki Tanaka et al: "Influence of mild exercise at the lactate threshold on glucose effectiveness"Journal of Applied Physiology. 87(6). 2305-2310 (1999)

Makoto Sakamoto、Hiroaki Tanaka 等人：“乳酸阈值下的轻度运动对葡萄糖有效性的影响”应用生理学杂志。