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A study of recovery mechanisms of motor functions by training after an artificial infarct of the premotor area in monkeys.

猴子运动前区人工梗死后通过训练恢复运动功能机制的研究。

基本信息

批准号：
09480243
负责人：
KUBOTA Kisou
金额：
$ 8.32万
依托单位：
NIHON FUKUSHI UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B).
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 2000
项目状态：
已结题

项目摘要

In 6 young adult rhesus monkeys, a delayed response task and/or a GO/NO-GO task were trained with use of the hand. In preliminary experiments, locations of the motor area and the dorsolateral premotor area of the hand were determined by intracortical microstimulation technique or GABAa antagonist, Bicuculline , injections. And then, artificial infarct of the premotor or motor area was made by producing ischemia by passing the current, by electrical lesion by passing current or by chemical lesion by ibotenic acid injection. Examined hand movement was 1) visual reaching of the hand. The monkey stretched the forearm to the inverted bottle cap to expose a piece of the apple hidden underneath the cap, and picked it up. Immediately after the lesion, the hand movement was disturbed, being the reaction time and movement time prolonged, and task performance was disrupted. In motor area lesion movement was more disturbed and in the premotor area the tasks were more disturbed. But by performing the task daily movement and performance recovered gradually. Immediately after the lesion, Bicuculline injections into the motor and premotor areas were not effective, indicating that facilitatory and inhibitory influences of the premotor area to the motor area were lost by the lesion. But training produced movement recovery. Probably new connections between premotor area and motor area are made by use of the hand movement..

在6只年轻的成年恒河猴中，使用手训练延迟反应任务和/或GO/NO-GO任务。在初步的实验中，运动区和背外侧运动前区的手的位置确定的皮质内微刺激技术或GABA α拮抗剂，荷包牡丹碱，注射。然后，通过通电流产生缺血、通过通电流产生电损伤或通过注射鹅膏蕈氨酸产生化学损伤来制造运动前区或运动区的人工梗塞。检查的手运动是1）手的视觉到达。猴子将前臂伸向倒置的瓶盖，露出隐藏在瓶盖下的一块苹果，然后把它捡起来。损伤后，手部运动立即受到干扰，反应时间和运动时间延长，任务执行受到干扰。在运动区病变的运动更受干扰，在运动前区的任务更受干扰。但通过执行任务，日常运动和性能逐渐恢复。损伤后立即将荷包牡丹碱注射到运动区和运动前区无效，表明运动前区对运动区的易化和抑制作用因损伤而丧失。但训练能使运动恢复。运动前区和运动区之间的新联系可能是通过手部运动建立的。