A study of recovery mechanisms of motor functions by training after an artificial infarct of the premotor area in monkeys.

猴子运动前区人工梗死后通过训练恢复运动功能机制的研究。

基本信息

批准号：
09480243
负责人：
KUBOTA Kisou
金额：
$ 8.32万
依托单位：
NIHON FUKUSHI UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B).
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 2000
项目状态：
已结题

项目摘要

In 6 young adult rhesus monkeys, a delayed response task and/or a GO/NO-GO task were trained with use of the hand. In preliminary experiments, locations of the motor area and the dorsolateral premotor area of the hand were determined by intracortical microstimulation technique or GABAa antagonist, Bicuculline , injections. And then, artificial infarct of the premotor or motor area was made by producing ischemia by passing the current, by electrical lesion by passing current or by chemical lesion by ibotenic acid injection. Examined hand movement was 1) visual reaching of the hand. The monkey stretched the forearm to the inverted bottle cap to expose a piece of the apple hidden underneath the cap, and picked it up. Immediately after the lesion, the hand movement was disturbed, being the reaction time and movement time prolonged, and task performance was disrupted. In motor area lesion movement was more disturbed and in the premotor area the tasks were more disturbed. But by performing the task daily movement and performance recovered gradually. Immediately after the lesion, Bicuculline injections into the motor and premotor areas were not effective, indicating that facilitatory and inhibitory influences of the premotor area to the motor area were lost by the lesion. But training produced movement recovery. Probably new connections between premotor area and motor area are made by use of the hand movement..

在6只年轻的成人恒河猴中，通过使用手的训练，延迟了响应任务和/或一项go/no-go任务。在初步实验中，手机区域的位置和手的背侧前前部区域是通过皮质内微刺激技术或GABAA拮抗剂Bicuculline的注射来确定的。然后，前者或运动区域的人工梗塞是通过通过电流传递电流或通过伊比培酸注射通过电流或化学病变来产生缺血的。检查的手移动是1）手的视觉范围。猴子将前臂伸到倒瓶盖，以露出隐藏在帽子下方的一块苹果，然后将其捡起。病变后，手动运动被打扰，是反应时间和运动时间延长，任务表现被中断。在运动区域中，病变运动更加干扰，在前运动区域中，任务更加干扰。但是，通过执行任务日常运动和绩效逐渐恢复。病变后，对运动前区域和前运动区域的双核氨酸注射无效，这表明在病变中失去了前运动区域对运动区域的促进性和抑制作用。但是训练产生了运动恢复。前者区域和运动区域之间的新连接可能是通过使用手移动来建立的。