A study of recovery mechanisms of motor functions by training after an artificial infarct of the premotor area in monkeys.

在6只年轻的成年恒河猴中，用手训练延迟反应任务和/或GO/NO-GO任务。在初步实验中，通过皮质内微刺激技术或注射GABAa拮抗剂Bicuculline来确定手的运动区和背外侧运动前区位置。然后通过通电致缺血、通电致电损伤或注射伊博滕酸致化学损伤等方法，对运动前区或运动区进行人工梗死。被检查的手的运动是手的视觉伸展。猴子把前臂伸到倒着的瓶盖上，露出了藏在瓶盖下面的一块苹果，然后把它捡了起来。病变发生后，手部运动受到干扰，反应时间和运动时间延长，任务表现受到干扰。运动区损伤对运动的干扰更大，运动前区损伤对任务的干扰更大。但通过执行任务，日常活动和表现逐渐恢复。损伤后，Bicuculline立即注射到运动区和运动前区无效，表明运动前区对运动区的促进和抑制作用因损伤而丧失。但是训练可以使运动恢复。运动前区和运动区之间的新联系可能是通过手部运动建立起来的。

In 6 young adult rhesus monkeys, a delayed response task and/or a GO/NO-GO task were trained with use of the hand. In preliminary experiments, locations of the motor area and the dorsolateral premotor area of the hand were determined by intracortical microstimulation technique or GABAa antagonist, Bicuculline , injections. And then, artificial infarct of the premotor or motor area was made by producing ischemia by passing the current, by electrical lesion by passing current or by chemical lesion by ibotenic acid injection. Examined hand movement was 1) visual reaching of the hand. The monkey stretched the forearm to the inverted bottle cap to expose a piece of the apple hidden underneath the cap, and picked it up. Immediately after the lesion, the hand movement was disturbed, being the reaction time and movement time prolonged, and task performance was disrupted. In motor area lesion movement was more disturbed and in the premotor area the tasks were more disturbed. But by performing the task daily movement and performance recovered gradually. Immediately after the lesion, Bicuculline injections into the motor and premotor areas were not effective, indicating that facilitatory and inhibitory influences of the premotor area to the motor area were lost by the lesion. But training produced movement recovery. Probably new connections between premotor area and motor area are made by use of the hand movement..