A study of the functional development of motor area-premotor association area in rhesus monkeys.

恒河猴运动区-运动前联合区功能发育的研究。

• 批准号: 06454714
• 负责人: KUBOTA Kisou
• 金额: $ 4.61万
• 依托单位: Dept.of Social & Information Sciences, NIHON FUKUSHI UNIVERSITY (1996)Kyoto University (1994-1995)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06454714/
• 关键词: Muscimol; GABA; Rhesus Monkey; Motor area; premotor area; 運動記憶; 接近運動; 運動連合野; 視覚性到達運動; 手の機能; 発達; NMDAレセプター; GABA抑制

In newly born rhesus monkeys, a delayd response task and its modified version, a hiding task, were trained with use of the hand. To perform the task in a freely moving experimental room, the monkey had to open a small bottle cap with either hand and to pick up a piece of apple with either hand and bring it to the mouth. The monkey learned the task with 3-5s delay period in 2-4 months after birth. During the course of the learning the hand movement and the task, a GABA agonist, Muscimol and a GABA antagonist, Bicuculline methiodide, were injected directly into the motor area, premotor association arca and prefrontal cortex and disrupted movement and performence were observed. It was found that the GABA had an important role to learn a visually guided hand movement in the motor area, premotor assocition area and prefrontal cortex and that in each area specific function develops, i.e.initiation of the movement in the motor area, visuo-movement association and skill in the premotor association area and spatial working memory in the prefrontal cortex.

在新出生的恒河猴中，通过使用手的使用，延迟响应任务及其修改后的版本，一个隐藏的任务。为了在一个自由移动的实验室中执行任务，猴子必须用任何一只手打开一个小瓶盖，然后用任何一只手拿起一块苹果，然后将其带到嘴里。猴子在出生后2-4个月内以3-5s的延迟时间学习了任务。在学习过程中，手动运动和任务，GABA激动剂，Muscimol和GABA拮抗剂Bicuculline Methiodide直接注射到运动区域，前局部结合ARCA和前额叶皮层，并观察到破坏的运动和表现。发现GABA在学习运动区域，前侧协会区域和前额叶皮层的视觉指导性手动运动中起着重要作用，并且在每个区域中，特定功能都会发展，即运动区域中运动区域的运动，Visuo运动区域的运动，Visuo-Sofement Sosciotion和Pregotor关联区域以及前额叶前梭状胸腔皮质中的空间工作记忆。

项目成果

Sawaguchi, T., Yamane, I. and Kubota, K.: "Application of GABA antagonist Bicuculline to the premotor cortex reduces the ability to withhold reaching movements by well-trained monkeys in visually guided reaching task." Journal of Neurophysiology. 75(in pr

Sawaguchi, T.、Yamane, I. 和 Kubota, K.：“将 GABA 拮抗剂荷包牡丹碱应用于前运动皮层，会降低训练有素的猴子在视觉引导的伸手任务中抑制伸手动作的能力。”

Kubota,K.: "Motor cortical muscimol injection disrupts forelimb movement in freely moving monkeys" NeuroReport. 7. 2379-2384 (1996)

Kubota,K.：“运动皮层蝇蕈醇注射会扰乱自由活动的猴子的前肢运动”NeuroReport。

Toshiyuki Sawaguchi, Itaru Yamane, and Kisou Kubota: "Application of the GABA antagonist Bicuculline to the premotor cortex reduces the ability to withhold reaching movements by well-trained monkeys in visually guided reaching task" J.Neurophysiol. 75(5).

Toshiyuki Sawaguchi、Itaru Yamane 和 Kisou Kubota：“将 GABA 拮抗剂荷包牡丹碱应用于前运动皮层，会降低训练有素的猴子在视觉引导的伸手任务中抑制伸手动作的能力”J.Neurophysiol。

Kisou Kubota: "Motor cortical muscimol injection disrupts forelimb movement in freely moving monkeys" Neeuro Report. 7(10). 2379-2384 (1996)

Kisou Kubota：“运动皮层蝇蕈醇注射会扰乱自由活动的猴子的前肢运动”Neeuro 报告。

K.Kubota: "Hand-use development of infant rhesus monkeys." XVth Congress of the International Primatological Society. 15. 104 (1994)

K.Kubota：“恒河猴幼崽的手部使用发育。”