Development of a PET-measuring system for the monkey brain.

开发猴脑 PET 测量系统。

• 批准号: 06508004
• 负责人: KUBOTA Kisou
• 金额: $ 24.83万
• 依托单位: Dept.of Social & Information Sciences, NIHON FUKUSHI UNIVERSITY (1995-1996)Kyoto University (1994)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06508004/
• 关键词: PET; GO; NO-GO Task; Rhesus Monkey; Temporal Lobe; Entorhinal Cortex; サル; 前頭葉; ゴ-・ノ-ゴ-課題; 光反応課題; 運動前野; PreSMA野; 46野

While two rhesus monkeys were performing a simple visual reaction Lime task and a visually guided GO/NO-GO task with symmetrical reinforcement, a PET measurement was performed. Systems to let the monkey, sitting in a primate chair, perform the learned task and collect data of activity changes of the local blood flow with 0-15 water were completed. Continuous histology sections of the brain of two monkeys with Nissl stains were also completed. Therefore, mcasuremenltof the local blood flow during the task performance were successfully conducted and cytoarchitectural identifications of activated areas became possible. During a visual reaction time task, in addition to the conventional areal acrivation of the contralateral hand motor area, bilateral motor association areas (areas 6), and contralateral area 46 were activated. During a GO/NO-GO task, colored cue stimuli induced activations of the inferotemporal cortex (area 22) and entorhinal certex and hippocampal-parahipocampal gyri, suggesting their activation to remember the color and succeeding performance, and activation of the contralateral motor area, area 8 and preSMA,indicating their activations for selection of the GO or NO-GO performance.

当两只恒河猴进行简单的视觉反应Lime任务和具有对称强化的视觉引导的GO/NO-GO任务时，进行PET测量。系统，让猴子，坐在灵长类动物的椅子上，执行学习的任务，并收集数据的活动变化的局部血流与0-15水完成。还用尼氏染色法完成了两只猴子脑的连续组织学切片。因此，成功地进行了任务执行过程中局部血流的测定，并使激活区域的细胞结构鉴定成为可能。在视觉反应时间任务中，除了对侧手部运动区的常规区域性刺激外，双侧运动关联区（区域6）和对侧区域46也被激活。在GO/NO-GO任务中，彩色线索刺激诱导颞下皮层（22区）和内嗅角和海马旁回的激活，表明它们的激活是为了记住颜色和随后的表现，激活对侧运动区，8区和前SMA，表明它们的激活是为了选择GO或NO-GO表现。

项目成果

A.Mikami, I.Ando, K.Kubota, T.Sawaguchi, E.Yoshikawa, T.Kakiuchi, K.Nakamura and H.Tsukada: "Posterior cortical areas activated during visually-guided GO/NO-GO task : a PET study" Neurosci. Abs.22. 401

A.Mikami、I.Ando、K.Kubota、T.Sawaguchi、E.Yoshikawa、T.Kakiuchi、K.Nakamura 和 H.Tsukada：“视觉引导 GO/NO-GO 任务期间激活的后皮质区域：PET

Kubota, K.: "Cerebral contical are as inobleved in a GO/NO-GO Visual discrimiration task revealed by PET imaging in mnkeys" Neuosci. Abs.21. 935 (1995)

Kubota, K.：“在猴子的 PET 成像揭示的 GO/NO-GO 视觉辨别任务中，大脑皮质是不重要的” Neuosci。

K.Kubota, I.Ando, T.Sawaguchi, A.Mikami, K.Nakamura, K.Sawaguchi-Watanabe, E.Yoshikawa, T.Kakiuchi, and T.Tsukada: "(1995) Cerebral cortical areas involved in a GO/NO-GO visual discrimination task revealed by PET imaging in monkeys" Neurosci. Abs.21. 935

K.Kubota、I.Ando、T.Sawaguchi、A.Mikami、K.Nakamura、K.Sawaguchi-Watanabe、E.Yoshikawa、T.Kakiuchi 和 T.Tsukada：“（1995）参与 GO 的大脑皮层区域

Mikami,A.,Ando,I.,Kubota,K.,Sawaguchi,T.,Yoshikawa,E.,Kakiuchi,T.,Nakamura,K.,and Tsukada,H.: "Posterior cortical areas activated during visually-guided GO/NO-GO task : a PET study." Neurosci. Abs.22. 401 (1996)

Mikami,A.、Ando,I.、Kubota,K.、Sawaguchi,T.、Yoshikawa,E.、Kakiuchi,T.、Nakamura,K. 和 Tsukada,H.：“视觉引导期间激活的后皮质区域

I.Ando, T.Sawaguchi, K.Nakamura, E.Yoshikawa, H.Okada, H.Tsukada and K.Kubota: "(1994) Frontal cortical areas involved in simple hand movement ; a PET study in an awake monkey" Neurosci. Abs.20. 444

I.Ando、T.Sawaguchi、K.Nakamura、E.Yoshikawa、H.Okada、H.Tsukada 和 K.Kubota：“(1994) 涉及简单手部运动的额皮质区域；对清醒猴子的 PET 研究” Neurosci