Oxyenamides and Oxyencarbamates as novel building blocks for the rapid construction of molecular complexity

氧酰胺和氧氨基甲酸酯作为快速构建分子复杂性的新型构建模块

• 批准号: 455442975
• 负责人: Professor Dr. Georg Manolikakes
• 金额: --
• 依托单位: Fachrichtung Organische Chemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/455442975?language=en
• 关键词: Oxyenamides; Oxyencarbamates; novel; building; blocks

The efficient synthesis of complex molecules containing multiple stereocenters still represents a major challenge in organic chemistry. In the course of this project we establish 2-oxyenamides and the corresponding 2-oxyencarbamates as novel tools for the stereoselective synthesis of structurally complex molecules. Our goals are modular processes for a controlled construction of as many stereoisomers as possible of a given molecule starting from a simple set of common building blocks. Finally we want to demonstrate the applicability of our methods in the synthesis of selected targets.

高效合成含有多个立体中心的复杂分子仍然是有机化学中的一个重大挑战。在这个项目的过程中，我们建立了2-氧烯酰胺和相应的2-氧烯氨基甲酸酯作为立体选择性合成结构复杂的分子的新工具。我们的目标是从一组简单的共同构建单元开始，对给定分子的尽可能多的立体异构体进行受控构建的模块化过程。最后，我们要证明我们的方法在选定的目标合成的适用性。