Enantioselective, decarboxylative 1,2-additions of carboxylic acids to aldehydes, ketones and imines - novel methods for the sustainable, asymmetric synthesis of alcohols and amines

羧酸与醛、酮和亚胺的对映选择性脱羧 1,2-加成——可持续、不对称合成醇和胺的新方法

基本信息

项目摘要

Chiral alcohols and amines are valuable building blocks in organic chemistry and a central structural motif in agrochemicals, natural products and active pharmaceutical ingredients. The enantioselective addition of organometallic compounds to aldehydes, ketones and imines is one oft the most important method for the preparation of these compound classes. The aim of this research project is the development of enantioselective, decarboxylative 1,2-additions of (hetero-)aromatic carboxylic acids to aldehydes, ketones and imines as novel, generally applicable approach towards chiral alcohols and amines. Replacement of the organometallic compound with a carboxylic acid leads to a higher atom- and step economy, resulting in more sustainable synthetic methods. Based on extensive mechanistic investigations, new catalyst-systems and -concepts for the highly enantioselective, decarboxylative addition of a broad range of carboxylic acids to various aldehydes, ketones and imines will be developed. Subsequently the relevance of these methods will be demonstrated in the synthesis of selected, particularly relevant alcohols and amines.
手性醇和胺是有机化学中有价值的结构单元,也是农用化学品、天然产物和活性药物成分的中心结构基元。有机金属化合物与醛、酮、亚胺的不对称加成反应是制备这类化合物的重要方法之一。本研究项目的目的是开发(杂)芳族羧酸对醛,酮和亚胺的对映选择性,脱羧1,2-加成,作为手性醇和胺的新的,普遍适用的方法。用羧酸取代有机金属化合物导致更高的原子和步骤经济性,从而产生更可持续的合成方法。基于广泛的机理研究,将开发新的催化剂系统和概念,用于高对映选择性,脱羧加成各种羧酸的各种醛,酮和亚胺。随后,这些方法的相关性将在选定的,特别是相关的醇和胺的合成中得到证明。

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Professor Dr. Georg Manolikakes其他文献

Professor Dr. Georg Manolikakes的其他文献

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{{ truncateString('Professor Dr. Georg Manolikakes', 18)}}的其他基金

Novel Multicomponent Reactions for the Synthesis of Sulfonamides
用于合成磺酰胺的新型多组分反应
  • 批准号:
    280954365
  • 财政年份:
    2015
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Oxyenamides and Oxyencarbamates as novel building blocks for the rapid construction of molecular complexity
氧酰胺和氧氨基甲酸酯作为快速构建分子复杂性的新型构建模块
  • 批准号:
    455442975
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
    Research Grants

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稳定的苄基亲核试剂的区域发散钯催化脱羧偶联
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Development of Decarboxylative and Desulfinative Cross-Coupling Strategies Towards Drug-Discovery, Materials and Biomass-Derived Platform Chemicals
开发药物发现、材料和生物质衍生平台化学品的脱羧和脱亚磺交叉偶联策略
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    RGPIN-2020-07211
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Development of a new reaction platform for direct decarboxylative cross-coupling of fatty acids
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    22K05206
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    2022
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Copper as a Photocatalyst: Applications in Decarboxylative Fluorination
铜作为光催化剂:在脱羧氟化中的应用
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Copper as a Photocatalyst: Applications in Decarboxylative Fluorination
铜作为光催化剂:在脱羧氟化中的应用
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Metal-, Catalyst-, Light- and Electrolysis-Free Decarboxylative Radical Reactions - Towards a More Sustainable Future
无金属、无催化剂、无光和无电解的脱羧自由基反应 - 迈向更可持续的未来
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    2518255
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    2021
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Decarboxylative [3+2] cycloaddition for the Synthesis of Hetisine-Type Alkaloids
脱羧[3 2]环加成合成Hetisine型生物碱
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Decarboxylative fluorination of aromatic carboxylic acids
芳香族羧酸的脱羧氟化
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Development of Decarboxylative and Desulfinative Cross-Coupling Strategies Towards Drug-Discovery, Materials and Biomass-Derived Platform Chemicals
开发药物发现、材料和生物质衍生平台化学品的脱羧和脱亚磺交叉偶联策略
  • 批准号:
    RGPIN-2020-07211
  • 财政年份:
    2021
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Metal-, Catalyst-, Light- and Electrolysis-Free Decarboxylative C-H Functionalisation of Heterocycles
杂环的无金属、无催化剂、无光和无电解脱羧 C-H 官能化
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