Novel Multicomponent Reactions for the Synthesis of Sulfonamides

磺酰基(-SO2-)是药物化学中含量最丰富的结构基元之一。目前已批准的含有磺胺、磺胺或磺酸酯官能团的药物有100多种。自80年代以来，具有磺胺官能团的分子属于最重要的药物。在2012年美国200种最常见的处方药中，近10%的药物含有磺胺基团。该项目的重点是开发制备磺胺类药物的新工艺。我们的目标是以一致和实用的方法合成各种结构不同的磺胺类化合物。因此，将发展几个互补的多组分反应。所有方法都将基于通过二氧化硫安装中心结构基元-磺酰基官能团。

The sulfonyl group (-SO2-) is one of the most abundant structural motifs in medicinal chemistry. Currently there are over 100 approved drugs containing a sulfon, sulfonamide or sulfonic ester functional group. Since 80 years molecules with a sulfonamide functionality belong to the most important drugs. Among the 200 most prescribed drugs in the US in 2012, close to 10% bear a sulfonamide group. This project is focused on the development of novel procedures for the preparation of sulfonamides. Our goal are consistent and practical methods for the modular synthesis of a wide variety of structurally diverse sulfonamides. Therefore several complementary multicomponent reactions will be developed. All methods will be based on the installation of the central structural motif, the sulfonyl functionality, via sulfur dioxide.