Novel Multicomponent Reactions for the Synthesis of Sulfonamides

用于合成磺酰胺的新型多组分反应

• 批准号: 280954365
• 负责人: Professor Dr. Georg Manolikakes
• 金额: --
• 依托单位: Fachrichtung Organische Chemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/280954365?language=en
• 关键词: Novel; Multicomponent; Reactions; Synthesis; Sulfonamides

The sulfonyl group (-SO2-) is one of the most abundant structural motifs in medicinal chemistry. Currently there are over 100 approved drugs containing a sulfon, sulfonamide or sulfonic ester functional group. Since 80 years molecules with a sulfonamide functionality belong to the most important drugs. Among the 200 most prescribed drugs in the US in 2012, close to 10% bear a sulfonamide group. This project is focused on the development of novel procedures for the preparation of sulfonamides. Our goal are consistent and practical methods for the modular synthesis of a wide variety of structurally diverse sulfonamides. Therefore several complementary multicomponent reactions will be developed. All methods will be based on the installation of the central structural motif, the sulfonyl functionality, via sulfur dioxide.

磺酰基（-SO2-）是药物化学中最丰富的结构基序之一。目前已有 100 多种含有磺基、磺酰胺或磺酸酯官能团的药物获得批准。自 80 年来，具有磺酰胺功能的分子属于最重要的药物。 2012 年美国处方最多的 200 种药物中，近 10% 含有磺胺类药物。该项目的重点是开发制备磺胺类药物的新方法。我们的目标是提供一致且实用的方法来模块化合成各种结构多样的磺酰胺。因此，将开发几种互补的多组分反应。所有方法都将基于通过二氧化硫安装中心结构基序、磺酰基官能团。

项目成果

Electron diffraction tomography and X-ray powder diffraction on photoredox catalyst PDI

• DOI: 10.1039/c8ce02026d
• 发表时间: 2019-04
• 期刊: CrystEngComm
• 影响因子: 3.1
• 作者: A. Bodach;Haishuang Zhao;Nai‐Wei Liu;E. Alig;G. Manolikakes;U. Kolb;L. Fink

Visible-light mediated 3-component synthesis of sulfonylated coumarins from sulfur dioxide

可见光介导二氧化硫三组分合成磺酰化香豆素

• DOI: 10.1039/c8gc00838h
• 发表时间: 2018-07-07
• 期刊: GREEN CHEMISTRY
• 影响因子: 9.8
• 作者: Chen, Zhengkai;Liu, Nai-Wei;Manolikakes, Georg
• 通讯作者: Manolikakes, Georg

Visible-Light-Induced 3-Component Synthesis of Sulfonylated Oxindoles by Fixation of Sulfur Dioxide

• DOI: 10.1002/ejoc.201801128
• 发表时间: 2018-11-08
• 期刊: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
• 影响因子: 2.8
• 作者: Liu, Nai-Wei;Chen, Zhengkai;Manolikakes, Georg
• 通讯作者: Manolikakes, Georg