Novel Multicomponent Reactions for the Synthesis of Sulfonamides

磺酰基（- so2 -）是药物化学中最丰富的结构基序之一。目前有超过100种批准的药物含有磺、磺酰胺或磺酸酯官能团。80年来，具有磺胺功能的分子是最重要的药物。在2012年美国200种最常用的处方药中，有近10%属于磺胺类。这个项目的重点是开发新的磺胺类药物的制备方法。我们的目标是一致和实用的方法，模块化合成各种结构多样的磺胺。因此，将发展几种互补的多组分反应。所有方法都将基于通过二氧化硫安装中心结构基序，磺酰基功能。

The sulfonyl group (-SO2-) is one of the most abundant structural motifs in medicinal chemistry. Currently there are over 100 approved drugs containing a sulfon, sulfonamide or sulfonic ester functional group. Since 80 years molecules with a sulfonamide functionality belong to the most important drugs. Among the 200 most prescribed drugs in the US in 2012, close to 10% bear a sulfonamide group. This project is focused on the development of novel procedures for the preparation of sulfonamides. Our goal are consistent and practical methods for the modular synthesis of a wide variety of structurally diverse sulfonamides. Therefore several complementary multicomponent reactions will be developed. All methods will be based on the installation of the central structural motif, the sulfonyl functionality, via sulfur dioxide.