Microwave-based Deprotonation Reactions with Alkyllithium Compounds

烷基锂化合物的微波去质子化反应

• 批准号: 455687658
• 负责人: Professor Dr. Carsten Strohmann
• 金额: --
• 依托单位: Forschungsgebiet Anorganische Chemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/455687658?language=en
• 关键词: Microwave; based; Deprotonation; Reactions; Alkyllithium

In the course of this research project, deprotonation reactions using alkyllithium compounds under microwave radiation are to be investigated in more detail. Up to now, the possibilities for the metalation of compounds whose deprotonation is kinetically inhibited, as well as multiple metalations, are still very limited. The activation barriers of these reactions are too high for conventional methods and are to be overcome by microwave radiation. In initial experiments, multiple metalation of simple organosilanes and aromatics as well as the α-metalation of tertiary amines was made possible for the first time, so that we see great potential in this method for extending the synthetically significant field of deprotonation reactions. Within the scope of the research project, the substrate spectrum will be extended and the combination of microwave technology with open reaction control or the use of microtube reactors will be investigated. The aim is to develop generally valid protocols applicable to a broad spectrum of starting materials, which make previously inhibited metalation reactions accessible.

在本研究项目中，将更详细地研究在微波辐射下使用烷基锂化合物的去质子化反应。到目前为止，其去质子化被动力学抑制的化合物的金属化的可能性，以及多个金属化，仍然是非常有限的。这些反应的活化势垒对于传统方法来说太高，需要通过微波辐射来克服。在最初的实验中，简单的有机硅烷和芳香族化合物的多重金属化以及叔胺的α-金属化首次成为可能，因此我们看到这种方法在扩展去质子化反应的合成重要领域方面的巨大潜力。在该研究项目的范围内，将扩展基底光谱，并将研究微波技术与开放反应控制或使用微管反应器的结合。其目的是开发适用于广谱起始材料的普遍有效的协议，使以前抑制的金属化反应。