权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Development of a new dual-contrast microangiographic system by using monochromatic synchrotron radiation

利用单色同步辐射开发新型双对比微血管造影系统

基本信息

批准号：
10470171
负责人：
TANAKA Etsuro
金额：
$ 8.58万
依托单位：
Tokai University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 2001
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-10470171/
关键词：
synchrotroon radiation microangiography 単色放射光循環障害

项目摘要

Monochromatic synchrotron radiation with an energy level of just above or below the k-edge of I, Ba, or Ce where a 2 x 2 cm area was scanned by a high-definition TV camera. This camera is an image pick-up tube with an amorphous selenium photoconductive target and is characterized by its internal amplification process, which uses the avalanche phenomenon in a photoconductive layer. The images were stored as a digital image (1024 x 1024 pixels, 4096 grades/pixel in a frame memory). The spatial resolution limit of this system was 25 μm. The detection limit of the vessel sizes are 30 μm in canine, rabbits, and rats. In the animal, the portal vein and bile duct in the liver were filled up with Ba-, Ce-, or I-labeled contrast materials. The pulmonary artery and the respiratory tract in the lung were also filled up with the contrast materials. The samples were exposed to monochromatic synchrotron radiation with just upper and lower energy levels of each K-edge in these elements. By subtraction processing on a computer, the image of these ducts up to 30 μm in diameter were taken separately. The use of a mechanical shutter to improve temporal resolution allowed 2 msec of one frame, which allowed us to obtain a fine image of the coronary artery in beating heart. We also showed that microsphere injection into the coronary artery created microvascular myocardial ischemia in dogs and rabbits.

单色同步加速器辐射，其能量水平略高于或低于 I、Ba 或 Ce 的 k 边缘，其中由高清电视摄像机扫描 2 x 2 cm 区域。该相机是一种具有非晶硒光电导目标的图像拾取管，其特征在于其内部放大过程，利用光电导层中的雪崩现象。图像被存储为数字图像（1024 x 1024 像素，帧存储器中 4096 级/像素）。该系统的空间分辨率极限为25μm。犬、兔和大鼠血管尺寸的检测限为 30 μm。在动物中，肝脏中的门静脉和胆管充满了 Ba、Ce 或 I 标记的造影剂。肺动脉和肺部呼吸道也充满造影剂。将样品暴露在单色同步加速器辐射下，这些元素中每个 K 边的能级只有上能级和下能级。通过计算机减法处理，分别拍摄这些直径达 30 μm 的导管的图像。使用机械快门来提高时间分辨率，一帧的时间为 2 毫秒，这使我们能够获得跳动心脏中冠状动脉的精细图像。我们还表明，将微球注射到冠状动脉中会导致狗和兔子的微血管心肌缺血。