The effects of cochlear pericytes and pericyte-related vascular pathology on hearing function

耳蜗周细胞及周细胞相关血管病理对听力功能的影响

基本信息

  • 批准号:
    10116361
  • 负责人:
  • 金额:
    $ 37.35万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-02-14 至 2025-01-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY Hearing loss has a profound impact on individuals, causing communication problems, social isolation, and cognitive decline. Microvascular pathology is a significant factor seen in many types of hearing loss, including sound-induced hearing loss, age-related hearing loss, genetic hearing loss, and autoimmune inner ear disease. Normal capillary blood flow is highly controlled by pericytes. The pericytes, specialized mural cells surrounding small blood vessels adjacent to endothelial cells, are vital for normal vascular function. Pericyte pathology, such as pericyte loss or degeneration, is a significant factor in degenerative neural diseases, including Alzheimer's disease and brain dementia. The cochlear microvasculature contains an abundant population of pericytes. However, the role of pericytes in the cochlea, in general, is understudied. In particular, their roles in vascular and hearing function is largely unknown. Using a combination of well-established and cutting-edge techniques, and building on preliminary data produced under R21 support, the proposed five-year research program continues the investigation of mechanisms outlined in our current R21 grant to further explore the role of PCs, PC-related vascular pathology, and angiogenesis in cochlear health. Success in this project will open new clinical options for treatment of aging-, noise exposure-, and genetic vascular deficiency-related deafness in which PCs are compromised.
项目总结

项目成果

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Xiaorui Shi其他文献

Xiaorui Shi的其他文献

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{{ truncateString('Xiaorui Shi', 18)}}的其他基金

The effects of cochlear pericytes and pericyte-related vascular pathology on hearing function
耳蜗周细胞及周细胞相关血管病理对听力功能的影响
  • 批准号:
    10553675
  • 财政年份:
    2020
  • 资助金额:
    $ 37.35万
  • 项目类别:
The effects of cochlear pericytes and pericyte-related vascular pathology on hearing function
耳蜗周细胞及周细胞相关血管病理对听力功能的影响
  • 批准号:
    10327721
  • 财政年份:
    2020
  • 资助金额:
    $ 37.35万
  • 项目类别:
Cochlear angiogenesis
耳蜗血管生成
  • 批准号:
    9298262
  • 财政年份:
    2017
  • 资助金额:
    $ 37.35万
  • 项目类别:
Strial vascular pathology from acoustic trauma
声损伤引起的心房血管病理学
  • 批准号:
    10174903
  • 财政年份:
    2017
  • 资助金额:
    $ 37.35万
  • 项目类别:
Strial vascular pathology from acoustic trauma
声损伤引起的心房血管病理学
  • 批准号:
    9383753
  • 财政年份:
    2017
  • 资助金额:
    $ 37.35万
  • 项目类别:
Perivascular macrophages endothelial interactions at the blood labyrinth barrier
血管周围巨噬细胞在血迷路屏障处的内皮相互作用
  • 批准号:
    8500225
  • 财政年份:
    2012
  • 资助金额:
    $ 37.35万
  • 项目类别:
Perivascular macrophages endothelial interactions at the blood labyrinth barrier
血管周围巨噬细胞在血迷路屏障处的内皮相互作用
  • 批准号:
    8386152
  • 财政年份:
    2012
  • 资助金额:
    $ 37.35万
  • 项目类别:
Fibrovascular coupling in the cochlea and pericyte recruitment after noise
噪声后耳蜗中的纤维血管耦合和周细胞募集
  • 批准号:
    8079462
  • 财政年份:
    2010
  • 资助金额:
    $ 37.35万
  • 项目类别:
Fibrovascular coupling in the cochlea and pericyte recruitment after noise
噪声后耳蜗中的纤维血管耦合和周细胞募集
  • 批准号:
    8664362
  • 财政年份:
    2010
  • 资助金额:
    $ 37.35万
  • 项目类别:
Fibrovascular coupling in the cochlea and pericyte recruitment after noise
噪声后耳蜗中的纤维血管耦合和周细胞募集
  • 批准号:
    8471544
  • 财政年份:
    2010
  • 资助金额:
    $ 37.35万
  • 项目类别:

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