The effects of cochlear pericytes and pericyte-related vascular pathology on hearing function
耳蜗周细胞及周细胞相关血管病理对听力功能的影响
基本信息
- 批准号:10116361
- 负责人:
- 金额:$ 37.35万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-02-14 至 2025-01-31
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAblationAction PotentialsAddressAdultAffectAfferent NeuronsAgingAlzheimer&aposs DiseaseAlzheimer&aposs disease brainAnimal ModelAnimalsAuditoryAuditory Brainstem ResponsesAutoimmune Inner Ear diseaseBlood VesselsBlood capillariesBlood flowBromodeoxyuridineCellsCellular StressClinicalCochleaCommunicationCoupledDataDementiaDendritesDependovirusEarEdemaEndothelial CellsEnhancersExtravasationGene TransferGenesGeneticGoalsGrantGrowthHair CellsHealthHearingHearing problemHomeostasisHypoxiaImmunoglobulin GImmunohistochemistryImpaired cognitionIndividualInfiltrationInflammationInvestigationIonsKnowledgeLabyrinthLeukocytesMaintenanceMeasuresMediatingMethodsMicrocirculationModelingNerve DegenerationNeurodegenerative DisordersNeuronsNoiseNuclearOpticsOrganPathologicPathologyPericytesPhasePopulationPresbycusisProliferatingResearchResolutionRoleScanning Electron MicroscopySerotypingSignal TransductionSignaling MoleculeSocial isolationStructureSwitch GenesTechniquesTestingTherapeuticTimeTissuesTransfectionVEGFA geneVascular DiseasesVascular Endothelial Growth FactorsVascular PermeabilitiesViral Vectorangiogenesisbaseblood perfusiondeafnessdensitygene therapyhair cell regenerationhearing impairmenthearing restorationhereditary hearing lossimprovedintravital fluorescence microscopymacromoleculemicroangiographymicrovascular pathologymouse modelneuron lossnormal hearingnovel therapeuticsotoacoustic emissionphenotypic biomarkerprogenitorprogramsquantitative imagingrepairedresponserestorationsoundspiral ganglionsuccessvector
项目摘要
PROJECT SUMMARY
Hearing loss has a profound impact on individuals, causing communication problems, social isolation, and cognitive
decline. Microvascular pathology is a significant factor seen in many types of hearing loss, including sound-induced
hearing loss, age-related hearing loss, genetic hearing loss, and autoimmune inner ear disease. Normal capillary
blood flow is highly controlled by pericytes. The pericytes, specialized mural cells surrounding small blood vessels
adjacent to endothelial cells, are vital for normal vascular function. Pericyte pathology, such as pericyte loss or
degeneration, is a significant factor in degenerative neural diseases, including Alzheimer's disease and brain
dementia. The cochlear microvasculature contains an abundant population of pericytes. However, the role of
pericytes in the cochlea, in general, is understudied. In particular, their roles in vascular and hearing function is
largely unknown. Using a combination of well-established and cutting-edge techniques, and building on preliminary
data produced under R21 support, the proposed five-year research program continues the investigation of
mechanisms outlined in our current R21 grant to further explore the role of PCs, PC-related vascular pathology,
and angiogenesis in cochlear health. Success in this project will open new clinical options for treatment of aging-,
noise exposure-, and genetic vascular deficiency-related deafness in which PCs are compromised.
项目摘要
听力损失对个人有着深远的影响,导致沟通问题,社会孤立和认知障碍。
下降微血管病变是许多类型听力损失的重要因素,包括声音诱发的听力损失。
听力损失、年龄相关性听力损失、遗传性听力损失和自身免疫性内耳疾病。毛细血管正常
血液流动高度受周细胞控制。周细胞是围绕在小血管周围的特殊壁细胞
与内皮细胞相邻,对正常血管功能至关重要。周细胞病变,如周细胞丢失或
神经退行性疾病,包括阿尔茨海默病和脑退化,是一个重要因素。
痴呆耳蜗微血管含有丰富的周细胞。然而,
耳蜗中的周细胞通常研究不足。特别是,它们在血管和听力功能中的作用是
大部分未知。使用成熟和尖端技术相结合,并在初步
在R21支持下产生的数据,拟议的五年研究计划继续调查
机制概述在我们目前的R21赠款,以进一步探讨PC的作用,PC相关的血管病理,
和耳蜗健康中的血管生成。该项目的成功将为治疗衰老开辟新的临床选择,
噪声暴露和遗传性血管缺陷相关的耳聋,其中PC受损。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Xiaorui Shi其他文献
Xiaorui Shi的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Xiaorui Shi', 18)}}的其他基金
The effects of cochlear pericytes and pericyte-related vascular pathology on hearing function
耳蜗周细胞及周细胞相关血管病理对听力功能的影响
- 批准号:
10553675 - 财政年份:2020
- 资助金额:
$ 37.35万 - 项目类别:
The effects of cochlear pericytes and pericyte-related vascular pathology on hearing function
耳蜗周细胞及周细胞相关血管病理对听力功能的影响
- 批准号:
10327721 - 财政年份:2020
- 资助金额:
$ 37.35万 - 项目类别:
Strial vascular pathology from acoustic trauma
声损伤引起的心房血管病理学
- 批准号:
10174903 - 财政年份:2017
- 资助金额:
$ 37.35万 - 项目类别:
Perivascular macrophages endothelial interactions at the blood labyrinth barrier
血管周围巨噬细胞在血迷路屏障处的内皮相互作用
- 批准号:
8386152 - 财政年份:2012
- 资助金额:
$ 37.35万 - 项目类别:
Perivascular macrophages endothelial interactions at the blood labyrinth barrier
血管周围巨噬细胞在血迷路屏障处的内皮相互作用
- 批准号:
8500225 - 财政年份:2012
- 资助金额:
$ 37.35万 - 项目类别:
Fibrovascular coupling in the cochlea and pericyte recruitment after noise
噪声后耳蜗中的纤维血管耦合和周细胞募集
- 批准号:
8079462 - 财政年份:2010
- 资助金额:
$ 37.35万 - 项目类别:
Fibrovascular coupling in the cochlea and pericyte recruitment after noise
噪声后耳蜗中的纤维血管耦合和周细胞募集
- 批准号:
8664362 - 财政年份:2010
- 资助金额:
$ 37.35万 - 项目类别:
Fibrovascular coupling in the cochlea and pericyte recruitment after noise
噪声后耳蜗中的纤维血管耦合和周细胞募集
- 批准号:
8471544 - 财政年份:2010
- 资助金额:
$ 37.35万 - 项目类别:
相似海外基金
心房細動に対するPulsed Field Ablationの組織創傷治癒過程を明らかにする網羅的研究
阐明房颤脉冲场消融组织伤口愈合过程的综合研究
- 批准号:
24K11201 - 财政年份:2024
- 资助金额:
$ 37.35万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Targeted ablation of cerebral atherosclerosis using supramolecular self-assembly
利用超分子自组装靶向消融脑动脉粥样硬化
- 批准号:
24K21101 - 财政年份:2024
- 资助金额:
$ 37.35万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
遅延造影心臓MRIによる心房細動Ablation冷却効果の比較:28 vs. 31 mm Cryoballoon
使用延迟对比增强心脏 MRI 比较房颤消融冷却效果:28 毫米与 31 毫米 Cryoballoon
- 批准号:
24K11281 - 财政年份:2024
- 资助金额:
$ 37.35万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
CAREER: Heat Penetration Depth and Direction Control with Closed-Loop Device for Precision Ablation
职业:利用闭环装置控制热穿透深度和方向,实现精确烧蚀
- 批准号:
2338890 - 财政年份:2024
- 资助金额:
$ 37.35万 - 项目类别:
Continuing Grant
Collaborative Research: RUI: Frontal Ablation Processes on Lake-terminating Glaciers and their Role in Glacier Change
合作研究:RUI:湖终止冰川的锋面消融过程及其在冰川变化中的作用
- 批准号:
2334777 - 财政年份:2024
- 资助金额:
$ 37.35万 - 项目类别:
Continuing Grant
Collaborative Research: RUI: Frontal Ablation Processes on Lake-terminating Glaciers and their Role in Glacier Change
合作研究:RUI:湖终止冰川的锋面消融过程及其在冰川变化中的作用
- 批准号:
2334775 - 财政年份:2024
- 资助金额:
$ 37.35万 - 项目类别:
Continuing Grant
InSPACE-VT_Development and Validation of Virtual Pace Mapping to Guide Catheter Ablation of Ventricular Tachycardia
InSPACE-VT_虚拟起搏测绘的开发和验证以指导室性心动过速导管消融
- 批准号:
EP/Z001145/1 - 财政年份:2024
- 资助金额:
$ 37.35万 - 项目类别:
Fellowship
Collaborative Research: RUI: Frontal Ablation Processes on Lake-terminating Glaciers and their Role in Glacier Change
合作研究:RUI:湖终止冰川的锋面消融过程及其在冰川变化中的作用
- 批准号:
2334776 - 财政年份:2024
- 资助金额:
$ 37.35万 - 项目类别:
Continuing Grant
MRI: Acquisition of a Laser Ablation - Inductively Coupled Plasma - Triple Quadrupole - Mass Spectrometer (LA-ICP-QQQ-MS) System For Research and Education
MRI:获取用于研究和教育的激光烧蚀 - 电感耦合等离子体 - 三重四极杆 - 质谱仪 (LA-ICP-MS/MS) 系统
- 批准号:
2320040 - 财政年份:2023
- 资助金额:
$ 37.35万 - 项目类别:
Standard Grant
Collaborative Research: CDS&E: An experimentally validated, interactive, data-enabled scientific computing platform for cardiac tissue ablation characterization and monitoring
合作研究:CDS
- 批准号:
2245152 - 财政年份:2023
- 资助金额:
$ 37.35万 - 项目类别:
Standard Grant