抗菌剤含有コラーゲンシートを用いたDrug Delivery Systemの研究

含抗菌剂胶原片给药系统的研究

• 批准号: 10470366
• 负责人: KANAI Atsushi
• 金额: $ 3.39万
• 依托单位: Juntendo University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-10470366/
• 关键词: Drug Delivery System; Collagen shield; Atelocollagen; Lomefloxacin; Ofloxacin; Nolfloxacin; Disposable soft contact lens; ロメフロキサシン; ドラッグデリバリーシステム; 抗菌剤; コラーゲンシート; 角膜感染症

1. A drug release for a long duration by the collagen plates containing anti-bacterial agents was studied for Drug delivery system as well as possibility of new hydrophilic disposable soft contact lens. The effect of temperature and ultraviolet irradiation on the dissolution rates of atelocollagen plates and alkali-soluble collagen plates were investigated. The dissolution rate of atelocollagen Plates was significantly higher at 40℃. The result indicated the dissolution rate of atelocollagen was varied by the duration of ultraviolet irradiation, which was the slowest release in 20 to 30 minutes. Atelocollagen plates were soaked for an hour in 0.3% ofloxacin (OFLX), Iomefloxacin (LFLX) or nolfloxacin (NFLX). The intake to the plate and relcase of each agent were investigated. The highest intake and Iongest duration of release was LFLX.2. By soaking the 1 Day Acuvue^<(R)>, Medalist^<(R)> and 14UV as known as new hydrophilic soft contact lens in the OFLX.LFLX, or NFLX solution for 4 hours, for evaluated their ability of up-take and release, The highest uptake and longest duration release was Acuvue^<(R)> soaked with LFLX.The concentration of LFLX in cornea and aqueous humor of rabbit eyes with wearing the Acuvue^<(R)> lens were measured. The concentration of LFLX was higher than MIC_<90> up to 8 hours and the highest level was shown from 2 to 4 hour.

1.研究了含抗菌药物的胶原片对药物的长时间释放，并探讨了新型亲水性一次性软性隐形眼镜的可能性。考察了温度和紫外光照射对胶原片和碱溶胶原片溶出度的影响。在40℃时，环状胶原板的溶出率明显高于对照组。结果表明，紫外光照射时间不同，胶原蛋白的溶出速度也不同，在20~30分钟内释放最慢。用0.3%氧氟沙星(OFLX)、伊美沙星(LFLX)或诺氟沙星(NFLX)浸泡Atelocollagen平板1小时。对每种药物的平板摄入量和复发率进行了调查。LFLX的摄入量最高，释放时间最长。将1day Acuvue^&lt；(R)&gt；、奖牌获得者^&lt；(R)&gt；和新型亲水性软性隐形眼镜14UV在OFLX.LFLX或NFLX溶液中浸泡4小时以评价其吸收和释放能力，其中Acuvue^&lt；(R)&gt；浸泡液摄取最多，释放时间最长。LFlx浓度在8h内高于MIC_(90)和Gt；，2~4h浓度最高。

项目成果

Tian X, Iwatsu M, Sado K, Kanai A: "Studied on the uptake and release of Flouroquinolones by disposable contact lens"CLAO Journal. (In press). (2001)

Tian X、Iwatsu M、Sado K、Kanai A：“一次性隐形眼镜对氟喹诺酮类药物的摄取和释放的研究”CLAO Journal。

小暮信行: "DDS (Drug delivery system) 使用目的の新しいコラーゲンシールドのための基礎研究"日本眼科学会雑誌. (印刷中). (2001)

Nobuyuki Kogure：“DDS（药物输送系统）新型胶原蛋白盾的基础研究”日本眼科学会杂志（2001 年出版）。

小暮信行: "DDS(Drug Delivery System)使用目的の新しいコラーゲンシールドのための基礎研究"日本眼科学会雑誌. (印刷中). (2001)

Nobuyuki Kogure：“DDS（药物输送系统）新型胶原蛋白盾的基础研究”日本眼科学会杂志（2001 年出版）。

Xin Tian: "Disposable 1day Acuvue^<【○!R】> contact lenses for the delivery of lomefloxacin to rabbit eyes"CLAO Journal. (In press). (2001)

田鑫：“用于向兔眼输送洛美沙星的一次性 1day Acuvue^<【○！R】> 隐形眼镜”CLAO 杂志（2001 年）。

Tian X, Iwatsu M, Kanai A: "Disposable 1 day Auvue contact lenses for the delivery of lomefloxacin to rabbit eyes"CLAO Journal. (In press). (2001)

Tian X、Iwatsu M、Kanai A：“用于向兔眼输送洛美沙星的一次性 1 天 Auvue 隐形眼镜”CLAO 杂志。