抗菌剤含有コラーゲンシートを用いたDrug Delivery Systemの研究

1.研究了含抗菌药物的胶原片对药物的长时间释放，并探讨了新型亲水性一次性软性隐形眼镜的可能性。考察了温度和紫外光照射对胶原片和碱溶胶原片溶出度的影响。在40℃时，环状胶原板的溶出率明显高于对照组。结果表明，紫外光照射时间不同，胶原蛋白的溶出速度也不同，在20~30分钟内释放最慢。用0.3%氧氟沙星(OFLX)、伊美沙星(LFLX)或诺氟沙星(NFLX)浸泡Atelocollagen平板1小时。对每种药物的平板摄入量和复发率进行了调查。LFLX的摄入量最高，释放时间最长。将1day Acuvue^&lt；(R)&gt；、奖牌获得者^&lt；(R)&gt；和新型亲水性软性隐形眼镜14UV在OFLX.LFLX或NFLX溶液中浸泡4小时以评价其吸收和释放能力，其中Acuvue^&lt；(R)&gt；浸泡液摄取最多，释放时间最长。LFlx浓度在8h内高于MIC_(90)和Gt；，2~4h浓度最高。

1. A drug release for a long duration by the collagen plates containing anti-bacterial agents was studied for Drug delivery system as well as possibility of new hydrophilic disposable soft contact lens. The effect of temperature and ultraviolet irradiation on the dissolution rates of atelocollagen plates and alkali-soluble collagen plates were investigated. The dissolution rate of atelocollagen Plates was significantly higher at 40℃. The result indicated the dissolution rate of atelocollagen was varied by the duration of ultraviolet irradiation, which was the slowest release in 20 to 30 minutes. Atelocollagen plates were soaked for an hour in 0.3% ofloxacin (OFLX), Iomefloxacin (LFLX) or nolfloxacin (NFLX). The intake to the plate and relcase of each agent were investigated. The highest intake and Iongest duration of release was LFLX.2. By soaking the 1 Day Acuvue^<(R)>, Medalist^<(R)> and 14UV as known as new hydrophilic soft contact lens in the OFLX.LFLX, or NFLX solution for 4 hours, for evaluated their ability of up-take and release, The highest uptake and longest duration release was Acuvue^<(R)> soaked with LFLX.The concentration of LFLX in cornea and aqueous humor of rabbit eyes with wearing the Acuvue^<(R)> lens were measured. The concentration of LFLX was higher than MIC_<90> up to 8 hours and the highest level was shown from 2 to 4 hour.