抗菌剤含有コラーゲンシートを用いたDrug Delivery Systemの研究

1.研究了含抗菌剂的胶原蛋白板作为药物释放系统的长期释药作用，以及新型亲水性一次性软性接触透镜的可能性。研究了温度和紫外线照射对去端胶原板和碱溶性胶原板溶解速率的影响。在40℃时，去端胶原板的溶出速率明显高于对照组。结果表明，去端肽胶原的溶出速率随紫外线照射时间的长短而变化，在20 ~ 30 min内释放最慢。将去端胶原平板在0.3%氧氟沙星（OFLX）、洛美沙星（LFLX）或诺氟沙星（NFLX）中浸泡1小时。研究了每种药剂对平板的摄入量和释放量。LFLX的摄入量最高，释放时间最长。通过将1 Day Acuvue、Medalist和14 UV作为已知的新型亲水性软接触透镜在OFLX、LFLX或NFLX溶液中浸泡4小时，以评价它们的摄取和释放能力，LFLX浸泡的Acuvue^<（R）>吸收量最高，释放持续时间最长。测量透镜。LFLX的浓度在8小时内均高于MIC_<90>（10），在2 ~ 4小时内达到最高水平。

1. A drug release for a long duration by the collagen plates containing anti-bacterial agents was studied for Drug delivery system as well as possibility of new hydrophilic disposable soft contact lens. The effect of temperature and ultraviolet irradiation on the dissolution rates of atelocollagen plates and alkali-soluble collagen plates were investigated. The dissolution rate of atelocollagen Plates was significantly higher at 40℃. The result indicated the dissolution rate of atelocollagen was varied by the duration of ultraviolet irradiation, which was the slowest release in 20 to 30 minutes. Atelocollagen plates were soaked for an hour in 0.3% ofloxacin (OFLX), Iomefloxacin (LFLX) or nolfloxacin (NFLX). The intake to the plate and relcase of each agent were investigated. The highest intake and Iongest duration of release was LFLX.2. By soaking the 1 Day Acuvue^<(R)>, Medalist^<(R)> and 14UV as known as new hydrophilic soft contact lens in the OFLX.LFLX, or NFLX solution for 4 hours, for evaluated their ability of up-take and release, The highest uptake and longest duration release was Acuvue^<(R)> soaked with LFLX.The concentration of LFLX in cornea and aqueous humor of rabbit eyes with wearing the Acuvue^<(R)> lens were measured. The concentration of LFLX was higher than MIC_<90> up to 8 hours and the highest level was shown from 2 to 4 hour.