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Development of advanced ESR crystallographic system (software and hardware) and ESR imaging system and these applications

先进ESR晶体学系统（软件和硬件）和ESR成像系统的开发及其应用

基本信息

批准号：
10555005
负责人：
KOBAYASHI Tadashi
金额：
$ 8.51万
依托单位：
Oita University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B).
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 2000
项目状态：
已结题

项目摘要

We have been engaging in the development of the 30 ESR apparatuses (hardware) and the computer analysis system of ESR crystallography (software). In the former case, several universal and particular ESR sample cavities, several 2-circle and 3-circle ESR goniometers, ESR apparatuses for applying uniaxial stress and electric field and so on have been developed so far. In the latter case, the direct search method for determining spin Hamiltonian parameters, the simplex method to refine the spin Hamiltonian parameters, the interface soft between X-ray and ESR crystallographic systems, for example, the program to draw the ESR tensors in the figure of crystal structure by using ORTEP and so on have been constructed.On the other hand, several ESR imaging apparatuses adopting a localized (ESR) signal detective method or a magnetic field gradient one have been developed. The former is the X-band ESR imaging (ESR-CT) apparatus with a pin-hole TE102 mode cavity and a rapid scan coils. The latter are the ESR imaging apparatus with a TM1 10 mode cavity and 3-dimentional field gradient coils (anti-Hclmholtz coils and Anderson coils pairs) and the high resolution ESR microscope with Zupancic MRI coils and dielectric resonator and so on. Using these apparatuses, ESR imaging of melanin in mouse B16 melanoma was observed for the first time. The 3-dimentional ESR dosimetry system has been constructed by using the ESR imaging plate made of alanine or sucrose.

我们一直致力于30台电子自旋共振仪（硬件）和电子自旋共振晶体学计算机分析系统（软件）的开发。在前者中，迄今已研制出几种通用和专用的ESR样品腔，几种二圈和三圈ESR测角仪，单轴应力和电场的ESR装置等。在后一种情况下，建立了确定自旋哈密顿参数的直接搜索法、精化自旋哈密顿参数的单纯形法、X射线与ESR晶体学系统之间的接口软件，如用ORTEP绘制晶体结构图中ESR张量的程序等。已经开发了几种采用定域（ESR）信号检测方法或磁场梯度检测方法的ESR成像设备。前者是X波段ESR成像（ESR-CT）装置，采用针孔TE_（102）模腔和快速扫描线圈。后者是采用TM-1 10模谐振腔和三维场梯度线圈（反Hclmholtz线圈和安德森线圈对）的ESR成像装置和采用Zupancic MRI线圈和介质谐振器的高分辨ESR显微镜等，首次观察了小鼠B16黑色素的ESR成像。用丙氨酸或蔗糖制成的ESR成像板，建立了三维ESR剂量学系统。