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Nutritional and Biochemical Studiees on Vitamin D and Its Active Derivatives for Preventing Osteoporosis

维生素D及其活性衍生物预防骨质疏松的营养生化研究

基本信息

批准号：
06454603
负责人：
KOBAYASHI Tadashi
金额：
$ 1.54万
依托单位：
Kobe Pharmaceutical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1996
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06454603/
关键词：
Active firm of vitamin D Osteoporosis Parathyroid hormone Vitamin D receptor Calcium Bone formation Bone resorption Calcitonin

项目摘要

We have investigated the nutritional and biochemical problems on vitamin D and its active derivatives and the following results have been obtained :(1) When the effects of dietary calcium and vitamin D on vitamin D-defficient rats, we found that sufficient amounts of oral supplementation of vitamin D gave positive effects on increasing bone mineral density (BMD) and mechanical bone strength (MBS) even calcium nutrtional status was low. The activity is more effective in male rats than in female rats.(2) 2beta- (Hydroxypropoxy) -1alpha, 25-dihydroxyvitamin D_3 (ED-71), a novel analog of 1alpha, 25-dihydroxyvitamin D_3 (active form of vitamin D_3), was confirmed to have longer hal life in blood than 1alpha, 25-dihydroxyvitamin D_3 and more effective for preventive and therpaeutic activity than 1alpha, 25-dihydroxyvitamin D_3.(3) The vitamin D nutritional status in institutionalized elderly people is lower than those in young subjects and therefore dietary intake of vitamin D is recommended for the elderly subjects.(4) Successive supplementation of vitamin D is useful for prevention and treatment of vitamin D deficiency. Daily intakes of 200 IU of vitamin D for adults including elderly people revealed to give positive effects on their vitamin D nutritional status.

我们对维生素D及其活性衍生物的营养和生化问题进行了研究，得到以下结果：(1)研究了维生素D缺乏症大鼠日粮钙和维生素D的影响，发现在钙营养状况较低的情况下，口服足量的维生素D对提高骨密度（BMD）和机械骨强度（MBS）有积极作用。这种活动在雄性大鼠中比在雌性大鼠中更有效。(2) 2 β - (Hydroxypropoxy) -1 α, 25-dihydroxyvitamin D_3 （ED-71）是1 α， 25-dihydroxyvitamin D_3（维生素D_3的活性形式）的一种新型类似物，在血液中的半衰期比1 α， 25-dihydroxyvitamin D_3长，具有比1 α， 25-dihydroxyvitamin D_3更有效的预防和治疗活性。(3)机构老年人的维生素D营养状况低于年轻受试者，建议老年人从膳食中摄入维生素D。(4)连续补充维生素D有助于预防和治疗维生素D缺乏症。包括老年人在内的成年人每天摄入200国际单位的维生素D会对他们的维生素D营养状况产生积极影响。