Development of novel photoreaction-driven percutaneous devices in cardiovascular field

心血管领域新型光反应驱动经皮装置的开发

• 批准号: 10558143
• 负责人: NAKAYAMA Yasuhide
• 金额: $ 6.21万
• 依托单位: National Cardiovascular Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-10558143/
• 关键词: photoreaction; percutaneous treatment; stent; adhesive glue; Embolic material; Surface Design; Cardiovascular Disease; Drug Delivery; 経皮デバイス; 医用接着剤; 塞栓材料; 細胞; 組織工学; 組織

The development of the devices and techniques for percutaneous treatment as a low invasion therapy in cardiovascular field are important especially in societies with many elderly people. Among them we have developed are as follows ; 1) visible light-induced tissue adhesive glue where styrenated gelatin and/or albumin-containing aqueous solutions with camphorquinone were gelated upon a few minutes of visible light irradiation, 2) embolic material for cerebral arteriovenous malformations and for local delivery of cytokines, 3) a novel high functional covered stent with micropore and drug delivery performance and hydrogel-coated stents both for prevention of restenosis and additionally a gene delivery device, and 4) the high performance balloon catheters with three functions of dilation of blood vessels, blood circulation and local delivery of drugs, all of which were driven by photochemistry. In addition, our efforts are also directed to application of gene therapy devices. We are pioneers in the development of these technologies and these techniques that will become the central in treatment of cardiovascular diseases.

开发用于心血管领域的低侵入疗法的经皮治疗装置和技术非常重要，尤其是在老年人较多的社会中。其中我们开发的有： 1) 可见光诱导的组织粘合胶，其中苯乙烯明胶和/或含有樟脑醌的白蛋白水溶液在可见光照射几分钟后凝胶化，2) 用于脑动静脉畸形和局部递送细胞因子的栓塞材料，3) 一种具有微孔和药物递送性能的新型高功能覆盖支架和水凝胶涂层支架 预防再狭窄和基因输送装置，4）具有扩张血管、血液循环和局部输送药物三种功能的高性能球囊导管，所有这些都是由光化学驱动的。此外，我们的努力还针对基因治疗设备的应用。我们是这些技术开发的先驱，这些技术将成为心血管疾病治疗的核心。

项目成果

中山泰秀: "人工臓器・組織工学における人工骨格設計(Scaffold Design):血管壁再構築モデルを用いた組織侵入過程のin vivo解析"人工臓器. 28. 528-532 (1999)

Yasuhide Nakayama：“人工器官/组织工程中的支架设计：使用血管壁重建模型对组织侵袭过程进行体内分析”Artificial Organ。

中山泰秀: "先端医療を支える高分子材料"高分子. 49. 113-116 (2000)

Yasuhide Nakayama：“支持先进医疗保健的高分子材料”Polymer 49. 113-116 (2000)。

DeFife KM: " Spatio regulation and surface chemistry control of monocyte/macrophage adhesion and foreign body giant cell formation by photochemically micropatterned surfaces"J Biomed Mater Res. 45. 148-154 (1999)

Deffe KM：“光化学微图案化表面对单核细胞/巨噬细胞粘附和异物巨细胞形成的空间调节和表面化学控制”J Biomed Mater Res。

Y.Nakayama: "Photocurable surgical tissue adhesive glues composed of photoreactive gelatin and poly(ethyele glycol) diacrylate"J Biomed Mater Res. 48. 511-521 (1999)

Y.Nakayama：“由光反应明胶和聚乙二醇二丙烯酸酯组成的光固化手术组织粘合剂”J Biomed Mater Res。

Y.Nakayama: "Scaffold design in tissue engineering : in vivo analysis of the tissue ingrowth process using a vascular reconstruction model"Jpn J Artif Organs. 28. 528-532 (1999)

Y.Nakayama：“组织工程中的支架设计：使用血管重建模型对组织长入过程进行体内分析”Jpn J Artif Organs。