Development of completely autologous aortic valves by a novel concept of regenerative medicine

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Tissue-engineering techniques may play a prominent role in the future development of cardiovascular replacements. Research designed to create in vitro tissue-engineered tissues has focused on the scaffold materials, culturing of cells, and its condition. As a feasible, regenerative medicine approach, this study developed cell-free devices for the preparation of completely autologous in vivo tissue-engineered cardiovascular tissues without any artificial scaffolds by using of in-body tissue architecture technology. The tissue formation process was enhanced successfully by design or photo engineering approaches. The biocompatibility was obtained by material engineering approach. We used a 3D printer to produce cell-free devices. The clinical feasibility of the valve-shaped tissues obtained from the devices was evaluated by their implanting in goats after evaluating their function and durability in vitro.