Design and Function of Dendrimer-Encapsulated Non-Heme Metalloprotein Mimi

树枝状聚合物封装的非血红素金属蛋白 Mimi 的设计和功能

• 批准号: 11450343
• 负责人: AIDA Takuzo
• 金额: $ 8.38万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11450343/
• 关键词: Dendrimer; Self-Assembly; Metallacycle; Metal-Metal Interaction; Super Helix; 酸素錯体; 銅錯体; 鉄錯体

Interesting "dendimer effects" were observed when the poly (benzyl ether) dendritic wedges are introduced into ligands such as triazacyclononane or pyrazole. In the former case, the stability of the bis (μ-oxo)-bridged dicopper complexes against thermal self-decomposition significantly depended on the bulkiness of the ligand. On the other hand, coordination metallacycles composed of Cu (I), Ag (I), or Au (I) with dendrimer-appended pyazole ligand self-assembled to various structures depending on the generation of the dendrimer. Such dendrimer-attached ligands will be a powerful module in biomimetic chemistry, supramolecular chemistry, and material science.

有趣的“树枝状二聚体效应”时，观察到的聚（苄基醚）树枝状楔被引入到配体，如三氮杂环壬烷或吡唑。在前一种情况下，双（μ-氧代）-桥联的二铜配合物对热自分解的稳定性显著依赖于配体的体积。另一方面，由Cu（I）、Ag（I）或Au（I）与树枝状聚合物附加的吡唑配体组成的配位金属杂环根据树枝状聚合物的生成自组装成各种结构。这种树枝状分子连接的配体将在仿生化学，超分子化学和材料科学中成为一个强大的模块。

项目成果

Masashi Enomoto and Takuzo AIDa: "Self-Assembly of a Copper-Ligating Dendrimer, that Provides a New Non-Heme Metalloprotein Mimic :"Journal of American Chemical Society. 121,4. 874-875 (1999)

Masashi Enomoto 和 Takuzo AIDa：“铜连接树枝状聚合物的自组装，提供了一种新的非血红素金属蛋白模拟物”：美国化学会杂志。

Masashi Enomoto,Akihiro Kishimura,and Takuzo Aida: "Coordination Metallacyclea of an Achiral Dendron Self-Assemble via Metal-Metol Interaction to Form Luminescent Superhelical Fibers"Journal of American Chemical Society. (in press).

Masashi Enomoto、Akihiro Kishimura 和 Takuzo Aida：“通过金属-甲醇相互作用形成非手性树枝自组装的配位金属环，形成发光超螺旋纤维”美国化学会杂志。

M.Enomoto and T.Aida: "Self-Assembly of a Copper-Ligating Dendrimer that Provides a New Non-Heme Metalloprotein Mimic : "Dendrimer Effects" on Stability of the Bis (μ-oxo) dicopper (III) Core"J.Am.Chem.Soc.. 121. 874-875 (1999)

M.Enomoto 和 T.Aida：“提供新型非血红素金属蛋白模拟物的铜连接树枝状聚合物的自组装：对双 (μ-oxo) 二铜 (III) 核心稳定性的“树枝状聚合物效应””J。美国化学学会 121. 874-875 (1999)

M.Enomoto, A.Kishimura, and T.Aida: "Coordination Metallacycles of an Achiral Dendron Self-Assemble via Metal-Metal Interaction to Form Luminescent Superhelical Fibers"J.Am.Chem.Soc.. (in press).

M.Enomoto、A.Kishimura 和 T.Aida：“非手性树枝状大分子通过金属-金属相互作用自组装的配位金属环形成发光超螺旋纤维”J.Am.Chem.Soc.（印刷中）。

Masashi Enomoto and Takuzo Aida: "Self-Assembly of a Copper-Ligating Dendrimer that Provides a New Non-Heme Metalloprotein Mimic :"Journal of the American chemical Society. 121・4. 874-875 (1999)

Masashi Enomoto 和 Takuzo Aida：“提供新型非血红素金属蛋白模拟物的铜连接树枝状聚合物的自组装”：美国化学会杂志 121・4（1999 年）。