Molecular Design for Micrometer-Scale Self-Assembly of Amphiphilic dendrimer

两亲性树枝状聚合物微米级自组装的分子设计

• 批准号: 10555322
• 负责人: AIDA Takuzo
• 金额: $ 4.61万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10555322/
• 关键词: Dendrimer; Self-organization; Hydrogen-bond; Physical Gel; Micelle; Micrometer-structure; Helix; Peptide; 水素結合相互作用; ファイバー; 階層的集合; 自己集合; 両親媒性デンドロン; 重合反応; 可溶化; 光開環・閉環反応; ミクロンスフェア

Dipeptide-core poly (benzyl ether) dendrimers, tert-Boc-Tyr(Ln)-Ala (Ln = n-layered dendritic wedge) (n = 3, 4), formed a physical gel in several organic solvents. The gel displayed strong CD bands at the absorption bands of the dendritic wedge, in addition to an enhanced CD band due to the dipeptide core. Infrared spectroscopy and DSC analysis indicated that the gelation occurs via hydrogen-bonding interactions of the dipeptide core, which are possibly stabilized by van der Waals forces among the dendritic wedges. SEM analysis showed that the dried gel contains micrometer-scale fibers, which are bundles of numerous elementary fibrils with a diameter of approximately 20 nm. In relation to this achievement, we also found that an amphiphilic poly (benzyl ether) dendrimer with an exterior carboxylic acid surface forms a uniform micelle with a diameter of 250nm in phosphate buffer solution at pH 6.3. These two findings provide a new strategy for the design of micrometer-scale superstructured dendritic materials with nanometric precision.

以二肽为核心的聚苄基醚树枝状大分子Tert-Boc-Tyr(Ln)-Ala(Ln=n-层状树枝状楔形)(n=3，4)在几种有机溶剂中形成了物理凝胶。该凝胶在树枝状楔形分子的吸收带上显示出较强的CD带，此外，由于二肽核心的作用，还显示了增强的CD带。红外光谱和DSC分析表明，凝胶是通过二肽核之间的氢键相互作用进行的，这种相互作用可能是由树枝间的范德华作用力稳定的。扫描电子显微镜分析表明，干燥的凝胶中含有微米级的纤维，这些纤维是由许多直径约20 nm的基本纤维组成的束。关于这一成果，我们还发现，在pH 6.3的磷酸盐缓冲溶液中，表面带有羧酸的两亲性聚苄基醚树枝状大分子形成了直径为250 nm的均匀胶束。这两个发现为设计具有纳米精度的微米级超结构树枝晶材料提供了一种新的策略。

项目成果

WOo-Dong Jong, Dong-Lin Jong, Takuzo Aida: "Dendritic Physical Gel: Hierarchical Self-Organization of a Peptide Core Dendrimer to Form a Micrometer-scale Fiber"The Journal of American Chemical Society. (in press).

WOo-Dong Jong、Dong-Lin Jong、Takuzo Aida：“树枝状物理凝胶：肽核心树枝状聚合物的分层自组织形成微米级纤维”美国化学会杂志。

Woo-Dong Jang,Dong-Lin Jiong,Takuzo Aida: "Dendriticphysical Gel : Hierarchical Self-Organization of a peptide Core Dendrimer to Form a Micro-Scale Fibrous Assembly"The Journal of Americal Chemical Society. (in press).

Woo-Dong Jang、Dong-Lin Jiong、Takuzo Aida：“树枝状物理凝胶：肽核心树枝状聚合物的分层自组织形成微型纤维组件”美国化学会杂志。

Woo-Dong Jang, Dong-Lin Jiay, Takuzo Aida: "Dendritic Physical gel : Hierarchial Self-organization of a Peptide Core Dendrimer to Form a Micrometer-scale"The Journal of American Chemical Society. (in press).

Woo-Dong Jang、Dong-Lin Jiay、Takuzo Aida：“树枝状物理凝胶：肽核心树枝状聚合物的分层自组织形成微米级”美国化学会杂志。