Search of novel nuclear orphan receptors for fat-soluble ligands

完整的氨基酸和饮食中的一些脂溶因子作为核受体的配体。在目前的研究中，维生素D的组织特异性作用已被VDR KO小鼠研究，这些小鼠只在断奶后才患上软骨病。此外，将这些小鼠与RxRγKo小鼠杂交，建立了VdR和RxRγ的双Ko小鼠，这些小鼠表现出更多的表型，表明维生素A和维生素D之间存在串扰。我们还搜索了新的核受体，发现了几个候选基因。

Some fat-soluble factors in intact aminals and diet act as ligands for nuclear receptors. In the present study, tissue-specific actions of vitamin D have been sudied by VDR KO mice, which develope rickets only after weaning. Furtherrmore, those mice were crossed with RXRγ Ko mice to establish double Ko mice for VDR and RXRγ, and the mice exhibited more over phenotypes, indicating a cross-talk between vitamin A and vitamin D.Conditional VDR KO in target tissues is under trial. We also searched novel nuclear receptors and found several candidates.