Hypertension and genetic polymorphism of angiotensinogen in a cohort study in Japanese workers

最近的许多病例对照研究表明，血管紧张素原（AGT）基因M235T（在密码子235位用苏氨酸取代蛋氨酸）多态性与高血压之间存在显著关系。为了研究AGT基因M235T多态性是否影响高血压的发病率，我们对日本工人进行了回顾性队列研究。研究对象为日本岛根县某职业场所的日本工人。基线数据是在1992年接受定期健康检查时设定的，1998年进行了回顾性队列研究以分析高血压的发病率。M235M （MM）、M235T （MT）和T235T （TT）基因型检出率分别为4%、32%和64%。单方差分析MT和TT对MM高血压发病率的相对危险度分别为1.47[95%可信区间（Cl） 0.50 ~ 4.33]和1.35 （95% Cl 0.47 ~ 3.90）。经性别、年龄、体重指数、空腹血糖、吸烟、饮酒和运动等因素调整后，1992年MT和TT对MM高血压发病率的相对危险度分别为1.49 （95% Cl 0.49 - 4.53）和1.25 （95% Cl 0.42 - 3.74）。本研究数据提示AGT基因M235T多态性在高血压的表现中作用较弱。解决这一问题需要进一步的全面研究。

Many recent case-control studies have suggested a significant relationship between M235T (the substitution of threonine for methionine at position 235 codon) polymorphism of the angiotensinogen (AGT) gene and hypertension. To investigate whether the M235T polymorphism of AGT gene affects the incidence of hypertension, a retrospective cohort study was performed among Japanese workers. The subjects were Japanese workers at an occupational site in Shimane Prefecture in Japan. The baseline data were set at the received regular health examination in 1992, and a retrospective cohort study was performed for analyzing the incidence of hypertension in 1998. The rates of M235M (MM), M235T (MT) and T235T (TT) genotypes were 4%, 32% and 64%, respectively. The relative risks of MT and TT against MM for the incidence of hypertension by single variance analysis were 1.47 [95% confidence interval (Cl) 0.50 - 4.33] and 1.35 (95% Cl 0.47 - 3.90), respectively. The relative risks of MT and TT against MM for the incidence of hypertension, adjusted for sex, age, body mass index, fasting glucose and cigarette smoking, drinking and exercise in 1992, were 1.49 (95% Cl 0.49 - 4.53) and 1.25 (95% Cl 0.42 - 3.74), respectively. The data from this study suggest that the M235T polymorphism of AGT gene has a weak role in the manifestation of hypertension. Further comprehensive studies are needed to resolve this issue.