Hypertension and genetic polymorphism of angiotensinogen in a cohort study in Japanese workers

日本工人的高血压与血管紧张素原基因多态性的队列研究

• 批准号: 11470096
• 负责人: KISHIMOTO Takuji
• 金额: $ 9.47万
• 依托单位: Tottori University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11470096/
• 关键词: hypertension; angiotensinogen; polymorphism; cohort study

Many recent case-control studies have suggested a significant relationship between M235T (the substitution of threonine for methionine at position 235 codon) polymorphism of the angiotensinogen (AGT) gene and hypertension. To investigate whether the M235T polymorphism of AGT gene affects the incidence of hypertension, a retrospective cohort study was performed among Japanese workers. The subjects were Japanese workers at an occupational site in Shimane Prefecture in Japan. The baseline data were set at the received regular health examination in 1992, and a retrospective cohort study was performed for analyzing the incidence of hypertension in 1998. The rates of M235M (MM), M235T (MT) and T235T (TT) genotypes were 4%, 32% and 64%, respectively. The relative risks of MT and TT against MM for the incidence of hypertension by single variance analysis were 1.47 [95% confidence interval (Cl) 0.50 - 4.33] and 1.35 (95% Cl 0.47 - 3.90), respectively. The relative risks of MT and TT against MM for the incidence of hypertension, adjusted for sex, age, body mass index, fasting glucose and cigarette smoking, drinking and exercise in 1992, were 1.49 (95% Cl 0.49 - 4.53) and 1.25 (95% Cl 0.42 - 3.74), respectively. The data from this study suggest that the M235T polymorphism of AGT gene has a weak role in the manifestation of hypertension. Further comprehensive studies are needed to resolve this issue.

近年来的病例对照研究表明，血管紧张素原（AGT）基因M235 T（第235位密码子苏氨酸取代蛋氨酸）多态性与高血压有显著的关系。为了探讨AGT基因M235 T多态性是否影响高血压的发病率，在日本工人中进行了一项回顾性队列研究。研究对象为日本岛根县某工地的日本工人。基线资料以1992年定期体检为起点，1998年进行回顾性队列研究，分析高血压的发病情况。M235 M（MM）、M235 T（MT）和T235 T（TT）基因型的检出率分别为4%、32%和64%。单因素方差分析显示MT和TT对MM高血压发生率的相对危险度分别为1.47 [95% CI 0.50 ~ 4.33]和1.35（95% CI 0.47 ~ 3.90）。1992年，经性别、年龄、体重指数、空腹血糖、吸烟、饮酒和运动校正后，MT和TT对MM高血压发病率的相对危险度分别为1.49（95%CI 0.49 - 4.53）和1.25（95%CI 0.42 - 3.74）。本研究结果提示AGT基因M235 T多态性在高血压发病中的作用较弱。要解决这个问题，还需要进行进一步的全面研究。

项目成果

Kishimoto T, Suyama A, Igarashi A, Osaki Y, Okamoto M, Yamamoto T, Nanba E, Kurosawa Y and Fukumoto S.: "Angiotensinogen Gene Variatiorn and Hypertension in a Cohort Study in Japanese."Journal of Epidemiology. 11(3) (in press).

Kishimoto T、Suyama A、Igarashi A、Osaki Y、Okamoto M、Yamamoto T、Nanba E、Kurosawa Y 和 Fukumoto S.：“日本队列研究中的血管紧张素原基因变异和高血压”。流行病学杂志。

Okada H,Suyama A,Osaki Y,Okamoto M,Yamamoto T,Kishmoto T, et. al: "Association of the Trp64Arg Mutation of the β3-Adrenergic Receptor with Diabetes Mellitus, Impaired Glucose Tolerance and Lifestyle in Japanese Workers."Yonago Acta Medica. 44・1. 55-59 (20

Okada H、Suyama A、Osaki Y、Okamoto M、Yamamoto T、Kishmoto T 等人：“β3-肾上腺素受体 Trp64Arg 突变与日本工人糖尿病、葡萄糖耐量受损和生活方式的关联。”Yonago Acta医学44·1。55-59（20）

Kishimoto T, Suyama A, Osaki Y, Miyamoto T, Igarashi A, Okamoto M, Kurosawa Y and Fukumoto S.: "A Molecular Variant of the Angiotensinogen Gene and Hypertension in a Case-Control Study in Japanese."Yonago Acta Medica. 44(1). 79-83 (2001)

Kishimoto T、Suyama A、Osaki Y、Miyamoto T、Igarashi A、Okamoto M、Kurosawa Y 和 Fukumoto S.：“日本病例对照研究中血管紧张素原基因的分子变异与高血压”。米子医学学报。

Okada H, Suyama A, Osaki Y, Okamoto M, Yamamoto T, Nanba E, Kishimoto T.: "Association of the Trp64Arg Mutation of the β3-Adrenergic Receptor with Diabetes Mellitus, Impaired Glucose Tolerance and Lifestyle in Japanese Workers."Yonago Acta Medica. 44(1).

Okada H、Suyama A、Osaki Y、Okamoto M、Yamamoto T、Nanba E、Kishimoto T.：“β3-肾上腺素受体 Trp64Arg 突变与日本工人糖尿病、葡萄糖耐量受损和生活方式的关联。”Yonago Acta医学44（1）。

Kishimoto T,Suyama A,Osaki Y,Miyamoto T,Igarashi A, et.al.: "A Molecular Variant of the Angiotensinogen Gene and Hypertension in a Case-Control Study in Japanese."Yonago Acta Medica. 44・1. 79-83 (2001)

Kishimoto T、Suyama A、Osaki Y、Miyamoto T、Igarashi A 等人：“日本病例对照研究中的血管紧张素原基因的分子变异” 44・1。 83（2001）