An intervention study for the arteriosclerosis prevention considering NOS genetic polymorphism in the occupational area group

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Tendencies to brachial-ankle pulse wave velocity (baPWV) improvement were analyzed in subjects with a slight arteriosclerosis judged by baPWV in reporting group (weak intervention) and intervention group (strong intervention). In the reporting group, the significant improvement was not shown in both -786C allele carriers and non--786C allele carriers of the NOS T-786C genetic polymorphism. However, in the intervention group, a tendency to significant improvement was found in non--786C allele carriers. The effect by the intervention was suggested to be low in -786C allele carriers.