RESEARCH FOR PREVENTION OF HEPATOCELLULAR CARCINOMA ASSOCIATED WITH HCV INFECTION BASED ON ETIOLOGY OF HCC IN THE PREFECTURE WHERE INCIDENCE OF HCC IS HIGH

HCC高发地区基于HCC病因的HCV感染相关肝癌预防研究

基本信息

  • 批准号:
    11470107
  • 负责人:
  • 金额:
    $ 9.15万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 财政年份:
    1999
  • 资助国家:
    日本
  • 起止时间:
    1999 至 2001
  • 项目状态:
    已结题

项目摘要

Our purpose is to find out HCV carriers among healthy people systematically by screening and to establish the model for control of hepatitis and hepatocellular carcinoma (HCC) associated with HCV infection in order to reduce the mortality rate of HCC, and to evaluate its efficacy. We conclude in the following two ways.First, already total 68,486 residents in 34 towns in our prefecture were checked for HCV infection. In our system of screening, we make it a rule to judge finally whether HCV carrier or not, and inform the result to residents who were screened. We calculated prevalence of HCV at the age in 2000. For the first time, we cleared prevalence of HCV infection at high age groups ; at 70's years old age group the rate of anti HCV is 8.3 % and the rate of HCV carrier is 5.0 %.By the way, we analyzed the result of HCV screening for HCV infection in 30,341 residents in our city. 2962 residents (9.8 %) were positive at the first screening for anti-HCV by EIA method, but finally only 732 residents (2.4 %) were judged as HCV carriers. It suggests that we need to reconsider the method of first screening for anti HCV.Second, we calculated the mathematical model on data of clinical courses of 942 HCV carriers, who were found at the chance of HCV donation. We estimated that the incidence rate of HCC among asymptomatic carriers at the age of 40 years old was 10.6 % in male and 4.5 % in female. And we estimated that the incidence of HCC was very high in male over 60 years old and in female 70 years old.
本研究的目的是通过系统筛查,在健康人群中发现HCV携带者,建立HCV感染相关肝炎和肝癌的控制模型,以降低肝癌的死亡率,并评价其疗效。我们从以下两个方面得出结论:第一,我州34个乡镇的68,486名居民已经进行了HCV感染的检查。在我国的筛查体系中,对HCV携带者进行最终判定,并将结果告知接受筛查的居民,已成为一项制度。我们计算了2000年年龄段的HCV患病率。首次明确了高年龄组HCV感染的流行情况,70岁以上年龄组抗-HCV阳性率为8.3%,HCV携带率为5.0%,并对我市30,341名居民HCV感染筛查结果进行了分析。用EIA法初筛抗-HCV阳性者2962人(9.8%),最终检出HCV携带者732人(2.4%)。其次,对942例因献血而发现的HCV携带者的临床病程资料进行了数学模型的计算。我们估计40岁时无症状携带者中肝癌的发病率男性为10.6%,女性为4.5%。估计肝癌发病率在男性60岁以上和女性70岁以上人群中较高。

项目成果

期刊论文数量(125)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
田中純子: "慢性肝炎診療マニュアル"医学書院. 138 (2001)
Junko Tanaka:《慢性肝炎治疗手册》Igaku Shoin 138(2001)。
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    0
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吉澤浩司: "病院論に基づいた肝炎・肝がん対策"Ortho HCV Frontier. 42. 2-19 (2001)
吉泽浩二:“基于医院理论的肝炎和肝癌对策”Ortho HCV Frontier 42. 2-19 (2001)。
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    0
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吉澤浩司: "ウイルス肝炎発生の動向調査"日本公衆衛生雑誌. 47(10). 461-462 (2000)
Koji Yoshizawa:“病毒性肝炎趋势调查”日本公共卫生杂志 47(10) (2000)。
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    0
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Fujiwara S et al.: "Prevalence of Anti-hepatitis C Virus Antibody and Chronic Liver Disease among Atomic Bomb Survivors"Radiation Research. 154. 12-19 (2000)
Fujiwara S等人:“原子弹幸存者中抗丙型肝炎病毒抗体的流行和慢性肝病”辐射研究。
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    0
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守屋 尚他: "院内感染発生後の対応 5)B型肝炎"医薬ジャーナル. 36・8. 127-129 (2000)
Moriya Nao等:“医院感染后的反应5)乙型肝炎”医药杂志36・8(2000)。
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    0
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YOSHIZAWA Hiroshi其他文献

YOSHIZAWA Hiroshi的其他文献

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{{ truncateString('YOSHIZAWA Hiroshi', 18)}}的其他基金

RESEARCH FOR PREVENTION OF HEPATOCELLULAR CARCINOMA CAUSED BY HCV INFECTION
HCV感染引起的肝细胞癌的预防研究
  • 批准号:
    09470115
  • 财政年份:
    1997
  • 资助金额:
    $ 9.15万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Sero-epidemiology and gene-epidemiology of HBV/HCV infection in the hyper endemic area of chronic liverdiseascs.
慢性肝病高流行区HBV/HCV感染的血清流行病学和基因流行病学。
  • 批准号:
    05454227
  • 财政年份:
    1993
  • 资助金额:
    $ 9.15万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)

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  • 批准号:
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  • 财政年份:
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estimated difference in long-term prognosis of HCV carriers with or without medical treatment-effectivity on check up system for HCV carrier in Japan-
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  • 批准号:
    15590513
  • 财政年份:
    2003
  • 资助金额:
    $ 9.15万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
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