RESEARCH FOR PREVENTION OF HEPATOCELLULAR CARCINOMA ASSOCIATED WITH HCV INFECTION BASED ON ETIOLOGY OF HCC IN THE PREFECTURE WHERE INCIDENCE OF HCC IS HIGH

我们的目的是通过筛查系统地发现健康人群中的丙型肝炎病毒携带者，并建立丙型肝炎病毒感染相关的肝炎和肝细胞癌的控制模型，以降低肝癌的死亡率，并评价其疗效。我们从以下两个方面得出结论：一是对我州34个镇的68486名居民进行了丙型肝炎病毒感染检查。在我们的筛查系统中，我们将最终判断是否携带丙型肝炎病毒作为规则，并将结果通知接受筛查的居民。我们计算了2000年时丙型肝炎病毒的流行率。首次明确了高龄人群丙型肝炎病毒感染的流行情况，70‘S年龄组抗-丙型肝炎病毒感染率为8.3%，丙型肝炎病毒携带率为5.0%。对我市30341名居民丙型肝炎病毒筛查结果进行分析。EIA法初筛抗-HCV阳性2962人(9.8%)，但最终被判定为丙型肝炎病毒携带者仅732人(2.4%)。其次，对942例献血机会发现的丙型肝炎病毒携带者的临床病程资料进行了数学模型计算。我们估计40岁无症状携带者的肝癌发病率男性为10.6%，女性为4.5%。我们估计，60岁以上的男性和70岁以上的女性的肝癌发病率非常高。

Our purpose is to find out HCV carriers among healthy people systematically by screening and to establish the model for control of hepatitis and hepatocellular carcinoma (HCC) associated with HCV infection in order to reduce the mortality rate of HCC, and to evaluate its efficacy. We conclude in the following two ways.First, already total 68,486 residents in 34 towns in our prefecture were checked for HCV infection. In our system of screening, we make it a rule to judge finally whether HCV carrier or not, and inform the result to residents who were screened. We calculated prevalence of HCV at the age in 2000. For the first time, we cleared prevalence of HCV infection at high age groups ; at 70's years old age group the rate of anti HCV is 8.3 % and the rate of HCV carrier is 5.0 %.By the way, we analyzed the result of HCV screening for HCV infection in 30,341 residents in our city. 2962 residents (9.8 %) were positive at the first screening for anti-HCV by EIA method, but finally only 732 residents (2.4 %) were judged as HCV carriers. It suggests that we need to reconsider the method of first screening for anti HCV.Second, we calculated the mathematical model on data of clinical courses of 942 HCV carriers, who were found at the chance of HCV donation. We estimated that the incidence rate of HCC among asymptomatic carriers at the age of 40 years old was 10.6 % in male and 4.5 % in female. And we estimated that the incidence of HCC was very high in male over 60 years old and in female 70 years old.