Sero-epidemiology and gene-epidemiology of HBV/HCV infection in the hyper endemic area of chronic liverdiseascs.

慢性肝病高流行区HBV/HCV感染的血清流行病学和基因流行病学。

• 批准号: 05454227
• 负责人: YOSHIZAWA Hiroshi
• 金额: $ 4.1万
• 依托单位: HIROSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05454227/
• 关键词: Hepatitis C virus (HCV); Polymerase chain reaction (PCR); HCV Genotype; Anti HCV; HCV carrier; Horizontal transmission; Vertical transmission; HCV関連抗体; 新規発生率; C型慢性肝炎; polymerase chain reacion(PCR); Genotype; branched DNA probe assay; RIBA-2

Sero-epidemiological and gene-epidemiological studies of HBV and/or HCV infection were conducted in areas showing high Stamdard Mortality Rate (SMR) by chronic liver diseases (chronic hepatitis, liver cirrhosis and hepatocellular carcinoma) and the following results were obtained.1.It appears that the correlation between SMR and the prevalence of HBV and/or HCV carriers is not clear, that is, areas showing high SMR caused by chronic lever diseases do not necessarily show high prevalence of HBV and/or HCV carries, or vice versa. Further study is necessary to elucidate this point.2.799 asymptomatic HCV carriers selected from blood donors were clinically diagnosed. 527 (66%) out of 799 cases were diagnosed as chronic liver disease, with one case of hepatocellular carcinoma and 7 cases of liver cirrhosis.3.The incidence rate of horizontal and/or vertical HCV transmission was studied. In the 2-year follow up study of a total of 80,530 blood donors, there was no case of horizontal transmission and there were 2 (2.3%) cases of vertical HCV transmission from 87 HCV carrier mothers.These findings will provided the basis for establishing strategy for control of chronic liver diseases.

慢性肝病（慢性肝炎，肝脏肝硬化和肝细胞癌）在表现出高阶段的阶段性阶段性死亡率（SMR）的区域进行了血清 - 发育学和基因 - 流行病学研究，以表现出高阶段的阶段性阶段性死亡率（SMR）。携带者尚不清楚，也就是说，显示由慢性杠杆疾病引起的高SMR的区域不一定显示出HBV和/或HCV携带的高患病率，反之亦然。为了阐明这一点，需要进一步的研究。2.799无症状的HCV携带者从临床上诊断出从献血者中选择。在799例病例中，有527例（66％）被诊断为慢性肝病，其中1例肝细胞癌和7例肝肝硬化病例。3。研究了水平和/或垂直HCV传播的发病率。在总共80,530名献血者的2年随访研究中，没有水平传播的情况，并且有2例（2.3％）垂直HCV从87 HCV载体母亲传播的病例。这些发现将为控制慢性肝脏疾病的控制提供策略。

项目成果

守屋 尚: "C型肝炎ウイルスの夫婦間感染に関する調査研究-遺伝子配列に基づくウイルス型分類を用いた検討-" 肝胆膵. 27. 1059-1062 (1993)

Takashi Moriya：“丙型肝炎病毒婚姻传播的调查 - 使用基于基因序列的病毒类型分类的研究”肝胆胰。 27. 1059-1062 (1993)

水井 正明: "C型肝炎ウイルス(HCV)キャリア献血者におけるHCVのGenotypeと5-1-1.C100-3に対する抗体との関係について" 肝臓. 34. 685 (1993)

Masaaki Mizui：“丙型肝炎病毒 (HCV) 携带者献血者中 HCV 基因型与抗 5-1-1.C100-3 抗体之间的关系” 肝脏。 34. 685 (1993)

Hiroshi Yoshizawa: "Screening tests of blood donors by HCV antibody" Rinshohi. (JPN). 20. 1568-1570 (1994)

Hiroshi Yoshizawa：“HCV 抗体对献血者的筛查测试”Rinshohi。

田中純子: "ウイルス肝炎の疫学" 医学のあゆみ. 171. 959-964 (1994)

Junko Tanaka：“病毒性肝炎的流行病学”医学史 171. 959-964 (1994)。

Hiroshi Yoshizawa: "Prevention of Post-transfusion Hepatitis in Japan" Viral hepatitis and liver disease. 544-557 (1994)

吉泽宏：《日本输血后肝炎的预防》病毒性肝炎和肝病。