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Sero-epidemiology and gene-epidemiology of HBV/HCV infection in the hyper endemic area of chronic liverdiseascs.

慢性肝病高流行区HBV/HCV感染的血清流行病学和基因流行病学。

基本信息

批准号：
05454227
负责人：
YOSHIZAWA Hiroshi
金额：
$ 4.1万
依托单位：
HIROSHIMA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1994
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05454227/
关键词：
Hepatitis C virus (HCV)Polymerase chain reaction (PCR)HCV Genotype Anti HCV HCV carrier Horizontal transmission Vertical transmission HCV関連抗体新規発生率 C型慢性肝炎 polymerase chain reacion(PCR)Genotype branched DNA probe assay RIBA-2

项目摘要

Sero-epidemiological and gene-epidemiological studies of HBV and/or HCV infection were conducted in areas showing high Stamdard Mortality Rate (SMR) by chronic liver diseases (chronic hepatitis, liver cirrhosis and hepatocellular carcinoma) and the following results were obtained.1.It appears that the correlation between SMR and the prevalence of HBV and/or HCV carriers is not clear, that is, areas showing high SMR caused by chronic lever diseases do not necessarily show high prevalence of HBV and/or HCV carries, or vice versa. Further study is necessary to elucidate this point.2.799 asymptomatic HCV carriers selected from blood donors were clinically diagnosed. 527 (66%) out of 799 cases were diagnosed as chronic liver disease, with one case of hepatocellular carcinoma and 7 cases of liver cirrhosis.3.The incidence rate of horizontal and/or vertical HCV transmission was studied. In the 2-year follow up study of a total of 80,530 blood donors, there was no case of horizontal transmission and there were 2 (2.3%) cases of vertical HCV transmission from 87 HCV carrier mothers.These findings will provided the basis for establishing strategy for control of chronic liver diseases.

在慢性肝病死亡率高的地区进行HBV和/或HCV感染的血清流行病学和基因流行病学研究（慢性肝炎、肝硬化和肝细胞癌）的临床研究结果表明：1. SMR与HBV和/或HCV携带者的患病率之间的相关性不明确，即SMR与HBV和/或HCV携带者的患病率之间的相关性不明确，即SMR与HBV和/或HCV携带者的患病率之间的相关性不明确。由慢性肝病引起的SMR高的地区不一定显示HBV和/或HCV携带者的高流行率，反之亦然。进一步的研究是必要的，以阐明这一点。2.799无症状的HCV携带者从献血员被临床诊断。慢性肝病527例（66%），其中肝细胞癌1例，肝硬化7例。3.研究HCV水平传播和/或垂直传播的发生率。对80,530名献血员进行了2年的随访研究，发现87名HCV携带者母亲中无HCV水平传播，2例（2.3%）发生HCV垂直传播，为制定慢性肝病防治策略提供了依据。