Discovery of new sex chromosome specific markers and those application to forensic medicine and human genetics

新性染色体特异性标记的发现及其在法医学和人类遗传学中的应用

• 批准号: 11470119
• 负责人: MATSUKI Takasumi
• 金额: $ 7.68万
• 依托单位: Fukui Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11470119/
• 关键词: DXS10011; Yfm1; DYS441; DYS442; DYS443; DYS444; DYS445; microsatellite; DYS442; DYS445; Y染色体; X染色体; Y chromosome; polymorphism; marker; male specific

We discovered DXS10011 as a X-chromosome specific single copy marker, Yfm1 as a Y-chromosome specific multi-copy marker, DYS441, DYS442, DYS443, DYS44 and DYS445 as Y-chromosome specific single copy markers. These markers were developed for personal identification and paternity testing from forensic specimens and applied on several cases. We obtained good resolution on those cases using these markers developed on this research project.

发现DXS10011为X染色体特异性单拷贝标记，Yfm1为Y染色体特异性多拷贝标记，DYS441、DYS442、DYS443、DYS44和DYS445为Y染色体特异性单拷贝标记。这些标记物被开发用于法医标本的个人识别和亲子鉴定，并应用于几个案例。我们使用本研究项目开发的这些标记物对这些病例获得了良好的分辨率。

项目成果

Kato M, Kanai M, Soma O, Takusa Y, Kimura T, Numakura C, Matsuki T, Nakamura S, Hayasaka K: "Mutation of the doublecortin gene in male-patients with double cortex syndrome somatic mosaicism detected by hair root analysis"Annals Neurology. 50(4). 547-551 (

Kato M、Kanai M、Soma O、Takusa Y、Kimura T、Numakura C、Matsuki T、Nakamura S、Hayasaka K：“通过发根分析检测双皮质综合征体细胞嵌合男性患者双皮质素基因突变”

Iida R, Tsubota E, Masuyama M, Takatsuka H, Matsuki T, Yasuda T, Sawazaki K, Yamada T, Ogata Y, Kishi K: "Identification and haplotype analysis of 5 novel polymorphic Y-STRs. In : DNA Polymorphism vol.10. (Ed) Japanese Society for DNA Polymorphism Researc

Iida R、Tsubota E、Masuyama M、Takatsuka H、Matsuki T、Yasuda T、Sawazaki K、Yamada T、Ogata Y、Kishi K：“5 个新型多态性 Y-STR 的鉴定和单倍型分析。见：DNA 多态性第 10 卷

Kato M, et al.: "Mutation of the doublecortin gene in male patients with double cortex syndrome : somatic mosaicism detected by hair root analvsis"Annals Neurology. 50(4). 547-551 (2001)

Kato M 等人：“双皮质综合征男性患者双皮质素基因突变：通过发根分析检测体细胞嵌合”《神经病学年鉴》。

Iida R, Tsubota E, Matsuki T: "Identification and characterization of two novel human polymorphic STRs on Y chromosome."Int J Legal Med. 115(1). 54-56 (2001)

Iida R、Tsubota E、Matsuki T：“Y 染色体上两种新型人类多态性 STR 的鉴定和表征。”Int J Legal Med。

Matsuki T, Tsubota E, Iida R, Kuroki Y, Nakahori Y: "Yfm 1 : a polymorphic multicopy marker on human Y chromosome. In : DNA Polymorphism vol.10. (Ed) Japanese Society for DNA Polymorphism Research"Toyoshoten, Tokyo, 2002, June. 173-175

Matsuki T、Tsubota E、Iida R、Kuroki Y、Nakahori Y：“Yfm 1：人类 Y 染色体上的多态性多拷贝标记。见：DNA 多态性第 10 卷。（编辑）日本 DNA 多态性研究学会”Toyoshoten，东京，