Experimental Study of Extrauterine Fetal Teatment for Congenital Diaphragmatic Hernia

先天性膈疝宫外胎儿治疗的实验研究

• 批准号: 11470367
• 负责人: YOSHINO Hiroaki
• 金额: $ 8.13万
• 依托单位: Akita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11470367/
• 关键词: Artificial Placenta; Estrauterine fetal incubation; ECMO; Fetal treatment; Congenital diaphragmatic hernia; Lamb; 胎児治療; 胎児鏡下手術

We have developed an extrauterine fetal incubation system using V-A ECMO via cervical vessels for the treatment of a fetus with a congenital diaphragmatic hernia. The purpose of this study was to examine the feasibility of extrauterine incubation of an isolated premature fetal lamb in the artificial placenta.The fetuses were(125〜140 days gestational age) were incubated in an isolated artificial amniotic fluid with VA ECMO.The fetuses were then removed from the incubator and ventilated through a tracheostomy.The circulation and respiratory state of fetuses during the incubation to ventilation were evaluated by blood gas analysis and colour Doppler ultrasonographic examinations revealed stablecondition undepended on hemodynaniic change of the ductus arteriosus and foramen ovale.These resuls may indicate that the cervical VA ECMO can effectively support extrauterine intubation of isolated premature fetuses.

我们已经开发了一个子宫外胎儿孵化系统，使用V-A ECMO通过宫颈血管治疗胎儿先天性腹股沟疝。本研究的目的是探讨人工胎盘对一只离体早产胎羊进行宫外孵育的可行性。（胎龄125至140天）将20例胎儿置于VA ECMO下的人工羊水中培养，然后将胎儿从培养箱中取出，通过气管切开进行通气，观察胎儿在培养至通气期间的循环和呼吸状态血气分析和彩色多普勒超声检查显示，VECMO能有效地支持孤立早产儿的宫外插管，且不依赖于动脉导管和卵圆孔血流动力学的变化。

项目成果

Hiroaki Yoshino, Tetsuo Kato: "Congenital Diaphragmatic Hernia"Rinsyo Fujinnka 54. 248-251 (2000)

Hiroaki Yoshino、Tetsuo Kato：“先天性膈疝”Rinsyo Fujinnka 54. 248-251 (2000)

吉野裕顕, 加藤哲夫: "先天性横隔膜ヘルニア"臨床婦人科産科. 54. 248-251 (2000)

Hiroaki Yoshino，Tetsuo Kato：“先天性膈疝”临床妇产科 54. 248-251 (2000)。

吉野裕顕: "外科治療の現況と産科へのアドバイスー胸部疾患:先天性横隔膜ヘルニア"臨床産婦人科. 54(3). 248-251 (2000)

Hiroaki Yoshino：“手术治疗的现状和对产科的建议 - 胸部疾病：先天性膈疝”临床妇产科 54(3) (2000)。