The effect of omega-3 fatty acids on hepatic stellate cell activation

肝星状细胞（HSC）储存维生素A，并且已知它们也负责肝纤维化。在儿童短肠患者中，口服omega-3脂肪酸可减少活化的HSC数量。使用从大鼠肝脏分离和培养的HSC，添加ω-3脂肪酸加速脂滴的形成并降低α-平滑肌肌动蛋白和I型胶原mRNA的表达水平。

Hepatic stellate cells (HSCs) store vitamin A and they are also known to be responsible for liver fibrosis. In child short bowel patients, oral administration of omega-3 fatty acids reduced the number of activated HSCs. Using HSCs isolated and cultured from rat liver, addition of omega-3 fatty acids accelerated formation of lipid droplets and decreased the expression levels of alpha-smooth muscle actin and type I collagen mRNAs.