The effect of omega-3 fatty acids on hepatic stellate cell activation

肝星状细胞（hsc）储存维生素A，它们也被认为是导致肝纤维化的原因。在儿童短肠患者中，口服omega-3脂肪酸可减少活化hsc的数量。使用从大鼠肝脏分离和培养的造血干细胞，添加omega-3脂肪酸加速脂滴的形成，降低α -平滑肌肌动蛋白和I型胶原mrna的表达水平。

Hepatic stellate cells (HSCs) store vitamin A and they are also known to be responsible for liver fibrosis. In child short bowel patients, oral administration of omega-3 fatty acids reduced the number of activated HSCs. Using HSCs isolated and cultured from rat liver, addition of omega-3 fatty acids accelerated formation of lipid droplets and decreased the expression levels of alpha-smooth muscle actin and type I collagen mRNAs.