Interactions of the peripheral and central inputs on the swallowing initiation

外周和中枢输入对吞咽启动的相互作用

• 批准号: 11470389
• 负责人: YAMADA Yoshiaki
• 金额: $ 9.15万
• 依托单位: NIIGATA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11470389/
• 关键词: swallow; elicitation; cortex; SLN stimulation; natural stimulation; 無麻酔・無拘束動物; 反射; 慢性刺激電極; 上喉頭神経; 電気刺激; 無麻酔、無拘束動物; 反射の変調

Swallowing is a primitive function necessary for the life support. Its motor behavior is controlled by a swallowing center, which is located in the medulla oblongata. This center generates highly coordinated motor sequence during swallowing. It is mainly composed of two parts; on e part consists of cells in the caudal region of the medulla and receives peripheral inputs; the other consists of motor nuclei in the ventral region of the medulla containing several cranial nerves, including the trigeminal (V), facial (VII), glossopharyngeal(IX), vagal(X) and hypoglossal(XII) nerves, operating the swallowing related muscies. It is also known that this mechanism receives inputs form other regions, such as respiratory center, chewing center and supramedullary regions. Interactions between the above mentioned regions are particularly unclear. The objective of the present study was to elucidate the interaction between these regions using freely behaving rabbits.It is concluded that advanced coordination may exist between the swallowing center, chewing center and supramedullary region. A hypothetic interaction between them is summarized.1)The swallowing center could not be under the fill control of the chewing center, but the generation of swallows might be controlled or synchronized by the chewing center.2) Conversely, the swallowing center might reset the chewing rhythm so that the chewing movement was slowed and the next chewing cycle began in the O_2 phase.3) The supramedullary region might send a tonic excitatory input to the swallowing center and maintain its excitability.4) The swallows elicited both by natural stlmull and the electrical SLN stimuli were concluded to be identical to each other.

吞咽是维持生命所必需的原始功能。它的运动行为由位于延髓的吞咽中枢控制。这个中心在吞咽过程中产生高度协调的运动序列。它主要由两部分组成;一部分由位于延髓尾侧区域的细胞组成，接受外周输入;另一部分由位于延髓腹侧区域的运动核组成，包含几个脑神经，包括三叉神经（V），面神经（VII），舌咽神经（IX），迷走神经（X）和舌下神经（XII），操作吞咽相关肌肉。还已知该机制接收来自其他区域的输入，诸如呼吸中心、咀嚼中心和髓上区域。上述区域之间的相互作用尤其不清楚。本研究的目的是阐明这些区域之间的相互作用使用自由behaving.It的结论是，高级协调之间可能存在的吞咽中心，咀嚼中心和髓上区。1）吞咽中枢可能不受咀嚼中枢的控制，但吞咽的产生可能受咀嚼中枢的控制或同步化; 2）相反，吞咽中枢可能受咀嚼中枢的控制或同步化。吞咽中枢可能重新设定咀嚼节律，使咀嚼运动减慢，下一个咀嚼周期开始于O_2相。延髓上区可能向吞咽中枢发送紧张性兴奋性输入，并维持其兴奋性。4）自然刺激和电刺激SLN诱发的吞咽反应是一致的。

项目成果

宮岡里美: "食塊量の増減に伴う嚥下感覚の変化-お茶を用いた実験"日摂食嚥下リハ会誌. 5・1. 25-31 (2001)

Satomi Miyaoka：“由于推注量的增加或减少而引起的吞咽感觉的变化 - 使用茶的实验”日本吞咽康复学会杂志 5·1（2001）。

植田耕一郎: "歯科施設における摂食・嚥下障害に対する(入院、外来、在宅、訪問)リハビリテーションの臨床的検討"日摂食嚥下リハ会誌. 4(2). 55-63 (2000)

Koichiro Ueda：“牙科机构中饮食和吞咽障碍康复的临床回顾（住院、门诊、家庭、家访）”日本饮食和吞咽康复学会杂志 4(2)。

北川純一: "マウスとラットにおける舌咽神経咽頭枝のうま味応答性の比較"日本味と匂学会誌. 7. 535-538 (2000)

Junichi Kitakawa：“小鼠和大鼠舌咽神经咽支鲜味反应性的比较”日本味觉学会杂志 7. 535-538 (2000)。

高橋肇: "嚥下困難者用「粥」の評価"日摂食嚥下リハ会誌. 3(2). 36-46 (1999)

Hajime Takahashi：“吞咽困难者的粥的评估”日本吞咽康复学会杂志 3(2) (1999)。

Yamada, K.: "Relationship between frontal facial morphology and occlusal force in orthodontic patients with temporomandibular disorder"J. Oral Rehabilitation. 26(in press). (2000)

Yamada, K.：“颞下颌疾病正畸患者额面部形态与咬合力的关系”J.