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Effect of Exercise Training on Glucose Effectiveness Assessed by 2-compartment labelled minimal moelel

通过 2 室标记最小 moelel 评估运动训练对血糖有效性的影响

基本信息

批准号：
11480005
负责人：
TOKUYAMA Kumpei
金额：
$ 8.64万
依托单位：
University of Tsukuba, Institute of Health and Sport Sciences
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2001
项目状态：
已结题

项目摘要

Glucose itself can enhance glucose disposal and suppress production independent of a change in insulin. Although literature abounds with reports of effect of exercise on insulin sensitivity (SI), there is a paucity of literature relating to the effect of physical exercise on glucose effectiveness. We have studied pathogenesis of glucose intolerance and beneficial effects of exercise on glucose effectiveness (SG) by minimal model approach, which is a mathematical model to analyze time course of glucose and insulin during intravenous glucose tolerance test. Although there was a heterogeneity in SI and pancreatic insulin secretion in subjects with impaired-glucose tolerance (IGT) and non insulin dependent diabetes mellitus (NIDDM), at least one of the two is reduced resulting in reduced insulin action. Decreased SG was common hi IGT and NIDDM subjects regardless of their insulin sensitivity index. Furthermore, adopting stable-labeled glucose enabled us to isolate peripheral component of SI (SI^<2*>) and SG (SG^<2*>) and both indexes are enhanced in endurance trained subjects. Endogenous glucose production (EGP) of NIDDM patients was suppressed but it was less than that of controls suggesting that hepatic glucose effectiveness specific to suppressing EGP is decreased in NIDDM. In endurance trained athletes, EGP at basal condition was enhanced, is suppressed similarly during the first 30 min of IVGTT, recovered faster and overshot greater than those of control subjects. SG^<2*> and basal EGP positively correlate. The higher basal EGP and greater EGP-overshoot of endurance trained athletes function to compensate for the higher peripheral glucose demand in order to maintain glucose homeostasis.

葡萄糖本身可以增强葡萄糖的处理和抑制生产独立于胰岛素的变化。尽管文献中有大量关于运动对胰岛素敏感性（SI）影响的报道，但关于体育锻炼对葡萄糖有效性影响的文献却很少。本文采用最小模型法研究了葡萄糖耐受不良的发病机制和运动对葡萄糖效能（SG）的有益影响。最小模型法是一种分析静脉葡萄糖耐量试验中葡萄糖和胰岛素时间过程的数学模型。尽管在糖耐量受损（IGT）和非胰岛素依赖型糖尿病（NIDDM）患者中，SI和胰腺胰岛素分泌存在异质性，但两者中至少有一种减少导致胰岛素作用降低。无论胰岛素敏感性指数如何，IGT和NIDDM患者普遍存在SG下降。此外，采用稳定标记的葡萄糖使我们能够分离出SI （SI^<2*>）和SG （SG^<2*>）的外周成分，并且这两项指标在耐力训练的受试者中都得到了增强。NIDDM患者的内源性葡萄糖生成（EGP）受到抑制，但低于对照组，这表明NIDDM患者抑制EGP的肝糖有效性降低。耐力训练的运动员EGP在基础条件下增强，在IVGTT前30分钟同样受到抑制，恢复速度更快，超调幅度更大。SG^<2*>与基础EGP呈正相关。耐力训练运动员较高的基础EGP和更大的EGP超调可以补偿较高的外周葡萄糖需求，以维持葡萄糖稳态。