Investigation of Natural Drug Resouces in Lam Dong Province, Vietnam and Shan State, Myanmar

越南林同省、缅甸掸邦天然药物资源考察

• 批准号: 13576027
• 负责人: KADOTA Shigetoshi
• 金额: $ 3.71万
• 依托单位: TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13576027/
• 关键词: agarwood; traditional medicine; Aquilaria crassna; Panax vietnamensis; liver disease; Panax zinziberensis; anti-narcotic action; Orthosiphon stamineus; 薬草栽培; 癌転移; 薬用人参; アーティチョーク; マトリックスメタロプロテアーゼ

Investigations in Vietnam1. We have visited traditional medicine practitioners, hospitals, research institutes for science, forestry and cultivation in Hochiminh, Da Lat, Nha Trang, Tuy Hoa and Phan Thiet Cities to study traditional medicine and the cultivation of agarwood and Taxus, cinchona, artichoke. Approximately 260 kinds of crude drugs used by the local traditional medicine practitioners have been sampled.2. A natural alive Aquilaria crassna tree, which is known to produce agarwood, has been found in Khanh Hoa Province. We also have questioned the local people, who earn their living on agarwood, to learn about agarwood resources, proccessing, cultivation, grading and qualification. In order to preserve the natural resource of agarwood, the cultivation of A. crassna have been started in several places in Vietnam.Investigations in Myanmar1. We have visited traditional medicine practitioners, clinics, hospitals and drug stores in Shan State, mainly in Taunggyi and Lashio. We have interviewed traditional medicine practitioners in Taunggyi and Kyaukme to learn about proccessing and production of Shan State traditonal medicine and 75 kinds of crude drugs have been sampled. Moreover, a wild ginseng plant was found for the first time in Taunggyi.Research in Japan1. Extracts of Vietnamese crude drugs were prepared, creened for anti-metastasis, hepatoprotection searched for active constituents. The results have been reported in 30 articles in international scientific journal.2. The ginseng plant collected in Myanmar was identified to be Panax zingiberensis, which faces extinction in China and is highly protected. An article on the research result is in press.3. The result of the investigation on agarwood is to be published.4. A review on the research of Vietnamese crude drug Alpinia blepharocalyx has been published.5. Result on the study of the chemical constituents of a Vietnamese, Myanmar and Southeast Asian medicinal plant Orthosiphon stamineus has been published.

越南调查1。我们访问了胡志明市、达拉特、芽庄、图和和潘切市的传统医学从业者、医院、科学、林业和种植研究所，学习传统医学和沉香、红豆杉、金鸡纳、朝鲜蓟的种植。对当地传统医药从业人员使用的约260种药材进行了抽样。在庆和省发现了一棵天然的活沉香树，这棵树以生产沉香木而闻名。我们还询问了当地以沉香为生的人们，了解沉香的资源，加工，种植，分级和资格。为了保护沉香的天然资源，对沉香的栽培进行了研究。crassna已经在越南的几个地方开始。我们访问了掸邦的传统医药从业人员、诊所、医院和药店，主要是在东吉和腊戍。我们采访了东吉和皎梅的传统医药从业人员，了解掸邦传统医药的加工和生产情况，并对75种原料药进行了抽样调查。此外，在东吉首次发现野生人参植物。对越南药材进行提取、抗转移、保肝活性筛选，寻找活性成分。研究结果已在国际科学杂志上发表30篇文章.在缅甸采集的人参植物被鉴定为人参，在中国濒临灭绝，受到高度保护。研究结果的文章已在印刷中.对沉香的调查结果有待公布.综述了越南产中药山姜的研究概况.本文报道了越南、缅甸及东南亚药用植物Orthosiphon stamineus的化学成分研究结果。

项目成果

Ali M. S.: "Blepharocalyxins C-E, Three New Dimeric Diarylheptanoids, and Related Compounds from the Seeds of Alpinia blepharocalyx."J. Nat. Prod.. 64. 491-496 (2001)

Ali M. S.：“Blepharocalyxins C-E，三种新的二聚二芳基庚烷类化合物，以及来自高良姜种子的相关化合物。”J.

Tran Q. L.: "New Spirostanol Steroids and Steroidal Saponins from Roots and Rhizomes of Dracaena angustifolia, and Their Antiproliferative Activity."J. Nat. Prod.. 64. 1127-1132 (2001)

Tran Q. L.：“来自龙血树根和根茎的新螺甾烷醇类固醇和类固醇皂苷及其抗增殖活性。”J.

Adnyana I K.: "Three New Triterpenes from the Seeds of Combretum quadrangulare and Their Hepatoprotective Activity."J. Nat. Prod.. 64. 360-363 (2001)

Adnyana I K.：“风车子种子中的三种新三萜及其保肝活性。”J.

Awale S.: "Siphonols A-E : Novel Nitric Oxide Inhibitors from Orthosiphon Stamineus of Indenesia."Bioorg. Med. Chem. Lett.. 13. 31-35 (2003)

Awale S.：“Siphonols A-E：来自印度尼西亚 Orthosiphon Stamineus 的新型一氧化氮抑制剂。”Bioorg。

Jun-ya Ueda: "Antiproliferative activity of Vietnamese Medicinal Plants"Biological Pharmaceutical Bulletin. 25・6. 753-760 (2002)

Jun-ya Ueda：“越南药用植物的抗增殖活性”生物制药通报25・6（2002）。