A random sample cohort study for developing a risk assessment method for vertebral and clinical fractures

一项随机样本队列研究，用于开发椎骨和临床骨折的风险评估方法

• 批准号: 14370147
• 负责人: IKI Masayuki
• 金额: $ 8.83万
• 依托单位: Kinki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14370147/
• 关键词: Bone mineral density; Genetic factors; Interactions; Lifestyle factors; Osteoporosis; Preventive procedures; Tailor-made prevention; Vitamin D receptor genotype

We performed in 2002 a follow-up study six years after the baseline and an addition survey for clinical fractures in 2003.The results obtained were as follows :(1)The number of eligible subjects for the follow-up study was 1588 and 1173(73.9%) completed the study.(2)Factors suggested to reduce bone loss were as follows : maintaining or gaining weight, exercise more than once a week, intake of a grass of milk per day or more, dietary calcium intake more than 750mg per day, and intake of fermented soybean, "natto", 3 times a week or more.(3)We determined incident clinical fractures during the follow-up period through the interviews at follow-up and an additional mailing survey for the subjects who did not visit the study. The total number of fracture was 121 including 56 fractures having occurred with low-energy impact, 26 forearm fractures and 3 hip fractures.(4)The risk of osteoporotic fractures significantly increased with the decrease in bone mineral density at the spine and total hi … More p but not at the distal radius. However, the risk of forearm fractures in the lowest bone density category at the distal radius was 8 times higher than that in the highest category and the corresponding risks were 4 at the spine and 10 at the total hip.(5)We determined genotypes of polymorphisms at the 3-end,5-end and promoter region of the VDR gene. The allele frequency of each polymorphism was similar to the previously reported for Japanese. However, either of the polymorphism did not show a significant effect on bone density and incidence of clinical fractures. However, some significant interactions of the genotypes and lifestyle factors on bone density were observed, that is, Fok I polymorphism and milk intake or participation in a sport club in middle school age for premenopaus al women, and Apa I polymorphism and milk intake at baseline in postmenopausal women.The risk of osteoporotic fractures was represented by bone density but not by the polymorphisms evaluated in the present study. Effects of other genetic factors should be examined in further studies to implement a tailor-made prevention against osteoporosis and osteoporotic fractures. Less

2002年进行了基线后6年的随访研究，2003年进行了临床骨折的补充调查。结果如下：（1）随访研究的合格人数为1588人，完成研究的有1173人（73.9%）。（2）体重保持或增加、每周运动1次以上、每天摄入1克以上牛奶、每天钙摄入量750 mg以上、每周摄入3次以上发酵大豆、纳豆等可减少骨丢失。(3)We通过随访时的访谈和对未参加研究的受试者的额外邮寄调查，确定随访期间发生的临床骨折。骨折总数为121例，其中56例骨折发生于低能量撞击，26例前臂骨折和3例髋部骨折。（4）随着脊柱骨密度和总骨密度的降低，骨质疏松性骨折的危险性显著增加。 ...更多信息 但在桡骨远端没有。然而，在桡骨远端骨密度最低类别中发生前臂骨折的风险是最高类别中发生前臂骨折的风险的8倍，相应的风险是脊柱4例和全髋10例。(5)We测定VDR基因3-端、5-端和启动子区的多态性基因型。每个多态性的等位基因频率是相似的，以前报道的日本。然而，任何一种多态性对骨密度和临床骨折的发生率都没有显着影响。然而，在绝经前妇女中，Fok I基因多态性与牛奶摄入量或参加体育俱乐部的情况有显著交互作用，而在绝经后妇女中，阿帕I基因多态性与牛奶摄入量有显著交互作用，骨密度可代表骨质疏松性骨折的危险性，但本研究中的基因多态性不能代表骨质疏松性骨折的危险性。其他遗传因素的影响应在进一步的研究中进行检查，以实施针对骨质疏松症和骨质疏松性骨折的量身定制的预防。少

项目成果

Iki M, et al.: "Special Lecture : Combined effects of genetic and vehavioral factors on bone mineral density and ts change over three years in representative samples of the Japanese women."10th International Conference on the Combined Effects of Environme

Iki M 等人：“特别讲座：遗传和行为因素对日本女性代表性样本三年内骨矿物质密度和 ts 变化的综合影响。”第十届环境综合影响国际会议

Ikeda Y, Iki M, Morita A, et al.: "Age-specific values and cutoff levels for the diagnosis of osteoporosis in quantitative ultrasound measurements at the calcaneus with Sahara in healthy Japanese women"-JPOS Study-Calcif Tissue Int. 71. 1-9 (2002)

Ikeda Y、Iki M、Morita A 等人：“健康日本女性跟骨撒哈拉定量超声测量中诊断骨质疏松症的年龄特异性值和截止水平”-JPOS 研究-Calcif Tissue Int.

Iki M, et al.: "Predictive Value of Biochemical Markers of Bone Turnover for Subsequent Bone Loss and Fast Bone Losers."IOF World Congress on Osteoporosis, Lisbon, Portugal.. 05. 10-14 (2002)

Iki M 等人：“骨转换生化标记对后续骨丢失和快速骨丢失者的预测价值。”IOF 骨质疏松症世界大会，里斯本，葡萄牙.. 05. 10-14 (2002)

伊木雅之: "COMBINED EFFECTS OF GENETIC AND BEHAVIORAL FACTORS ON BONE DENSITY AND ITS CHANGE OVER THREE YEARS IN REPRESENTATIVE SAMPLES OF THE JAPANESE WOMEN"Archives of Complex Environmental Studies. (印刷中). (2004)

Masayuki Iki：“日本女性代表性样本中遗传和行为因素对骨密度及其三年变化的综合影响”复杂环境研究档案（2004 年）。

Iki M, et al.: "Effects of vitamin D receptor genotype on bone density and tis change over time in a representative sample of the Japanese female population."2nd Int Workshop on the Genetics of Bone Metab Dis. Davos, Switzerland.. 02. 15-18 (2003)

Iki M 等人：“维生素 D 受体基因型对日本女性群体代表性样本中骨密度及其随时间变化的影响。”第二届骨代谢障碍遗传学国际研讨会。