A large-scale random sample cohort study for planning preventive procedures of osteoporosis allowing for genetic risks

一项大规模随机样本队列研究，用于规划骨质疏松症的预防程序，考虑到遗传风险

• 批准号: 10470114
• 负责人: IKI Masayuki
• 金额: $ 7.94万
• 依托单位: Kinki University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-10470114/
• 关键词: Bone mineral density; Genetic factors; Interactions; Lifestyle factors; Osteoporosis; Preventive procedures; Tailor-made prevention; Vitamin D receptor genotype; 第1次予防; コホート研究; 遺伝子多型; リスク評価

We performed a follow-up study 3 years after the baseline on 1,650 Japanese women randomly selected from the inhabitants of three municipalities in different areas in Japan. Both studies comprised bone mineral density (BMD) measurement, detailed interviews on lifestyle factors and determination of the vitamin D receptor (VDR) genotype. 1285 subjects (80%) completed the follow-up study.The results obtained were as follows :(1) The greatest bone loss was observed around the age at menopause at the spine and forearm. At the femoral neck, however, the subjects aged 70 years and older showed the greatest loss.(2) Factors suggested to reduce bone loss were as follows : heavier weight, higher physical activity, greater intake of milk, greater intake of dietary calcium, frequent intake of fermented soybean "natto" and non-smoking.(3) We determined genotypes of 3-end and 5-end polymorphisms of the VDR gene. The allele frequency was similar to the previously reported for Japanese. However, either of the polymorphism did not show a significant effect on BMD.(4) Some significant interactions of the genotypes and lifestyle factors on BMD were observed. Exercise had a beneficial effect on BMD in the subjects with genotypes defined as tt and Tt at 3-end polymorphism and intake of milk did so in those with the genotypes FF and Ff at 5-end polymorphism.Genetic factors may play a less role in determining the bone mass after the acquisition of the peak bone mass in comparison with lifestyle factors. However, significant interactions of the VDR genotype and lifestyle factors observed in the present study suggest that preventive procedures for osteoporosis could be designed for an individual with a particular genotype, which may lead to tailor-made prevention in near future.

我们对从日本不同地区的三个市的居民中随机选择的1，650名日本妇女进行了基线后3年的随访研究。两项研究均包括骨矿物质密度（BMD）测量，生活方式因素的详细访谈和维生素D受体（VDR）基因型的测定。1285例（80%）完成随访，结果表明：（1）绝经前后骨丢失最大的部位是脊柱和前臂。然而，在股骨颈，70岁及以上的受试者表现出最大的损失。(2)体重增加、体力活动量增加、牛奶摄入量增加、膳食钙摄入量增加、经常食用发酵大豆“纳豆”和不吸烟是减少骨丢失的因素。(3)我们确定了VDR基因3端和5端多态性的基因型。等位基因频率与日本人的相似。然而，这两种多态性对BMD均无显著影响。(4)基因型和生活方式因素对骨密度的影响有显著的交互作用。运动对3-末端多态性为tt和Tt基因型的受试者的BMD有有益的影响，而摄入牛奶对5-末端多态性为FF和Ff基因型的受试者的BMD有有益的影响。然而，在本研究中观察到的VDR基因型和生活方式因素的显着相互作用表明，骨质疏松症的预防程序可以为具有特定基因型的个体设计，这可能会导致在不久的将来量身定制的预防。

项目成果

M.Iki 他5名: "Bone mineral density of the spine, hip and distal foream in representative samples of the Japanese female population-Japanese Population-based Osteoporosis (JPOS) Study-"Osteoporos Int. 12(印刷中). (2001)

M.Iki 和其他 5 人：“日本女性人群代表性样本中脊柱、髋部和远端前肢的骨矿物质密度 - 日本人口骨质疏松症 (JPOS) 研究 -”Osteoporos Int 12（出版中）。 ）

秋葉隆,伊木雅之 他7名: "日本人女性における骨代謝マーカーの年齢・閉経・骨密度との関連"Osteoporos Jpn. 9(印刷中). (2001)

Takashi Akiba、Masayuki Iki 等 7 人：“日本女性骨代谢标志物与年龄、更年期和骨密度的关系”Osteoporos Jpn 9（出版中）。

Akiba T, Iki M, et al.: "Association of biochemical markers of bone turnover with age, menopause and bone mineral density in Japanese female population-JPOS Study-."Osteoporos Jpn. 9 : (in press). (2001)

Akiba T、Iki M 等人：“日本女性群体中骨转换生化标志物与年龄、更年期和骨矿物质密度的关联 - JPOS 研究 -”Osteoporos Jpn。

Iki M, et al.: "Change in bone mineral density and its determinants in Japanese female population-JPOS Cohort Study-."Osteoporos Jpn. 9 : (in press). (2001)

Iki M 等人：“日本女性群体骨矿物质密度的变化及其决定因素 - JPOS 队列研究 -”Osteoporos Jpn。

Iki M, et al.: "Bone mineral density of the spine, hip and distal forearm in representative samples of the Japanese female population-Japanese Population-based Osteoporosis (JPOS) Study-."Osteoporos Int. 12 : (in press). (2001)

Iki M 等人：“日本女性群体代表性样本中脊柱、髋部和前臂远端的骨矿物质密度——日本人口骨质疏松症 (JPOS) 研究——”Osteoporos Int.