Intraocular pressure and glaucoma at working places-combined study of visual function, lifestyle and a pharmacological trial

目的：作为一项职业健康研究，重新评估正常眼压（IOP），试图探讨可能导致眼压变化的背景因素。在西方人群中，眼压随年龄增长而增加，而在日本，眼压已被证实随年龄增长而下降。如果不考虑系统条件和社会医学，就不能合理地解释这种矛盾的结果。参与者，主要结果测量和测试：我们研究了视力和健康项目中1709名受试者的IOPs。眼压12.5±2.9 mmHg，矫正视力0.39±0.25，收缩压134±22，舒张压72±12。参与者接受了访谈和详细的眼部检查，包括最小分辨角的对数、屈光、裂隙灯生物显微镜、解释眼压测量、角膜镜检查、白内障扩张、白内障分级和眼底评估。年龄与矫正视力（-0.069^<**>,3306）、收缩压与IOPs（0.177^<**>, 3292）、屈光不正与IOPs（-0.118^<**>, 2674）之间存在显著性差异。近视：虽然IOP升高与成人近视有关，但其对眼睛的潜在影响一直存在争议，因为人数没有统计学意义。近视情况为：<-20 （n=8）、-20≦< -10 （n=76）、-10≦<-5 （n=168）、-5≦<-2 （n=393）、-2≦<-1 （n=249）、-1（890）、1≦(n=890)，各组的IOPs有规律变化。结论及未来问题：为预防高眼压，2002-2003年进行了基因分析和药理研究，报告4篇。作为一个未来的问题，是否通过收缩压和年龄之间的相关性来充分解释眼压和年龄之间的任何明显的关联是一个开放性的问题。这项研究是由两位医生精心完成的，他们要么是副教授（首席研究员），要么是助理教授。少

PURPOSE :As an occupational health study, re-evaluation of normal intraocular pressure (IOP) was attempted to investigate possible background factors that contribute to variations in IOP. IOP increases with age among Western populations, while in the Japanese IOP has been confirmed to decrease with aging. Such paradoxical results cannot be reasonably explained without considering systemic conditions and social medicine.PARTICIP ANTS, MAIN OUTCOME MEASURES and TESTING :We studied IOPs of 1709 subjects in our vision and health program. The IOPs are 12.5±2.9 mmHg, corrected vision was 0.39±0.25, systolic blood pressure (BP) 134±22, diastolic BP 72±12. The participants underwent an interview and detailed eye examination that included logarithm of minimum angle of resolution visual acuity, refraction, slit-lamp biomicroscopy, explanation tonometry, gonioscopy, dilation, cataract grading, and fundus evaluation.Relating several states such as myopia and cardiovascular systems, statistical sig … More nificance was observed between age and corrected vision (-0.069^<**>, 3306), between systolic BP and IOPs (0.177^<**>, 3292), between refractive error and IOPs (-0.118^<**>, 2674), respectively.Myopia : While elevated IOP is associated with myopia in adults, its potential influence on the eyes have been controversial, because number of people were not statistically meaningful. Myopic condition was : <-20 (n=8), -20≦ < -10 (n=76), -10≦ <-5 (n=168), -5≦ <-2 (n=393), -2≦ <-1 (n=249), -1(890), 1≦ (n=890), and the IOPs of each group was changed in a regular fashion.CONCLUSION and FUTURE PROBLEM :For preventing high IOP, gene analysis and pharmacological study was done in 2002-2003, and these were reported as 4 reports. As a future problem, it is open to question whether any apparent association between intraocular pressure and age was fully accounted for through the correlation between systolic BP and age. This research was done with care by two doctors who were either an associate professor (principal investigator) or an assistant professor. Less