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The combination therapy of mild-hyperthermia with therapeutic ultrasound and dendritic cell-based immunotherapy

The combination therapy of mild-hyperthermia with therapeutic ultrasound and dendritic cell-based immunotherapy
温和热疗与治疗性超声和基于树突状细胞的免疫疗法的联合治疗
批准号:
21700511
负责人:
SUZUKI Ryo
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010

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中文摘要
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英文摘要
Ultrasound (US) exposure to tumor tissue which was intratumorally injected nanobubbles (Bubble liposomes(BLs)), could induce anti-tumor effect by heating and shock waves derived from disruption of BLs. In addition, we found that strong tumor-specific immunity was induced by intratumoral injection of dendritic cells (DCs) after US therapy with BLs. The combination of US therapy with nanobubbles and DC-based immunotherapy efficiently suppressed tumor growth. Therefore, this might be a useful strategy for cancer therapy.
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DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Kumazawa, Takao, 秋吉一成, Yoshiyuki Sankai, 鈴木亮]
通讯作者: 鈴木亮
超音波感受性リポソームを利用したがん温熱療法と免疫療法の併用によるがん治療
癌症热疗和超声敏感脂质体免疫疗法相结合的癌症治疗
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [鈴木亮, 宇都口直樹, 丸山一雄]
通讯作者: 丸山一雄
DOI: 10.1089/hum.2009.106
发表时间: 2010-01-01
期刊: HUMAN GENE THERAPY
影响因子: 4.2
作者: [Un, Keita, Kawakami, Shigeru, Hashida, Mitsuru]
通讯作者: Hashida, Mitsuru
Development of novel antigen delivery system with liposomal bubbles (Bubble liposomes) and ultrasound in cancer immunotherapy
开发新型脂质体气泡(气泡脂质体)和超声波抗原递送系统在癌症免疫治疗中的应用
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Ryo Suzuki, Yusuke Oda, Naoki Utoguchi, Kazuo Maruyama]
通讯作者: Kazuo Maruyama
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