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Circulardichroismus (CD)-Spectrometer

圆二色性（CD）光谱仪

基本信息

批准号：
456842022
负责人：
金额：
--
依托单位：
Georg-August-Universität Göttingen
依托单位国家：
德国
项目类别：
Major Research Instrumentation
财政年份：
2021
资助国家：
德国
起止时间：
2020-12-31 至无数据
项目状态：
未结题

来源：
https://gepris.dfg.de/gepris/projekt/456842022?language=en
关键词：
Circulardichroismus CD Spectrometer

项目摘要

Chiral structures are ubiquitous in nature. In addition to diverse other compounds from plant-based renewable raw materials, carbohydrates as a large group of subtances contain both monosaccharides with distinct stereoisomers and polysaccharides, which can form not only different secondary structures but also crystalline structures. The secondary or even more complex structures that are formed via self-assembly of native or modified polysaccharid chains can have diverse morphologies and functions, for instance helical structures for stress changes. Moreover, the polysaccharide-based crystalline nanomaterials, such as cellulose and chitin nanocrystals, form chiral-nematic structures during the self-assembly in aqueous solutions. These self-assembled structures can be further modified or fixed in diverse materials. However, there is still a huge lack of research and analysis on all these self-assembled structures of polysaccharide chains and polysaccharide-based crystalline nanostructures as well as modified monosaccharides. Many self-assembled structures and fundamental physicochemical properties of these compounds are still overwhelming unknown.With the circular dichroismus spectrometer that is to be purchased, novel knowledge regarding these aspects will be obtained. In addition to the elucidation of the stereostructures of functionalized monosaccharides and the chiral structures of compounds from plant-based sustainable raw materials, the self-assembled secondary structures of polysaccharide derivatives and polysaccharide-based nanocrystals will be systematically studied in various on-going and planned projects.

手性结构在自然界中普遍存在。除了植物来源的其他化合物外，碳水化合物作为一大类物质，既含有具有不同立体异构体的单糖，又含有多糖类，它们不仅可以形成不同的二级结构，还可以形成晶体结构。通过天然或修饰的多糖链的自组装形成的二级或甚至更复杂的结构可以具有不同的形态和功能，例如用于应力变化的螺旋结构。此外，基于多糖基的结晶纳米材料，如纤维素和甲壳素纳米晶，在水溶液中自组装时形成手性向列结构。这些自组装结构可以进一步修饰或固定在不同的材料上。然而，目前对多糖链的自组装结构、基于多糖基的晶态纳米结构以及修饰单糖的研究和分析仍然非常缺乏。这些化合物的许多自组装结构和基本物理化学性质仍然是未知的。随着即将购买的圆二色光谱仪的购买，人们将获得关于这些方面的新知识。除了阐明功能化单糖的立体结构和植物基可持续原料化合物的手性结构外，多糖衍生物和多糖基纳米晶的自组装二级结构将在各种正在进行和计划中的项目中得到系统研究。