Change of the response of the periodontal ligament to mechanical stimulation with aging : from the aspect of the interrelation between microvasculature and the periodontal ligament cells

1.目的是阐明急性微血管对机械刺激的反应，特别是内皮细胞和白细胞之间的相互关系。对金仓鼠颊袋毛细血管后小静脉进行连续和间歇压力刺激。结果，在刺激的正下方，滚动和黏附的白细胞，尤其是单核细胞显著增加。目的是阐明机械刺激下微血管的长期形态学变化。采用背皮肤腔对仓鼠背皮肤进行连续和间歇压力刺激，活体显微镜观察7天毛细血管。结果表明，在连续增产下，渗透率明显提高。观察中发现血管新生，在间歇性刺激的第7天毛细血管直径增加了一倍。

1.The purpose was to clarify the acute microvascular reaction to mechanical stimulation especially on the interrelation between endothelial cells and white blood cells.Continuous and intermittent pressure stimulation was applied to post-capillary venule in the cheek pouch of golden hamsters. As a result, at the site just below the stimulation, rolling and adhering leukocytes especially monocytes were significantly increased.2.The purpose was to clarify the long-term morphological changes of the microvasculator under the mechanical stimulation. Continuous and intermittent pressure stimulation was applied to the dorsal skin of a hamster using a dorsal skin chamber, and observed capillaries using intravital microscopy for 7days. As a result, strong increase in the permeability was observed under the continuous stimulation. Angiogenesis was detected during the observation, and the diameter of capillaries was doubled at 7 days under the intermittent stimulation.