Control of alveolar bone metabolism activity with RAP induction andLIPUS irradiation

RAP 诱导和 LIPUS 照射控制牙槽骨代谢活性

• 批准号: 23659959
• 负责人: IIDA Junichiro
• 金额: $ 2.33万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659959/
• 关键词: 歯学細胞組織 医療; 福祉 生理活性 歯科矯正学; ＲＡＰ誘導; ＬＩＰＵＳ; 矯正学的歯の移動; ＬＩＰＵＳ照射; 骨代謝

RAP induction method: We investigated the treatment method for increasing the activity of osteoclasts (RAP) in local alveolar bone by using a rat maxillary first molars. As a result, we confirmed that it is effective to induce RAP induction when performing osteotomy with the depth reaching bone marrow in both labial and palatal sides at for the total of six portion. (2) LIPUS irradiation conditions: We investigated the irradiation method using ultrasound (LIPUS) irradiation, expecting an increase in osteogenic activity. But we did not yet obtain significant results of changes in formation ability of alveolar bone .

RAP诱导方法：以大鼠上颌第一磨牙为模型，探讨提高牙槽骨局部破骨细胞活性的治疗方法。因此，我们证实，在总共六个部分的情况下，当截骨深度达到唇侧和腭侧的骨髓时，诱导RAP是有效的。(2)LIPUS照射条件：我们研究了LIPUS照射方法，以期提高成骨活性。但我们尚未在牙槽骨形成能力的变化方面取得明显的结果。

项目成果

Short-term mechanical stress inhibits osteoclastogenesis via suppression of DC-STAMP in RAW264.7 cells

• DOI: 10.3892/ijmm.2012.1220
• 发表时间: 2013-02-01
• 期刊: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
• 影响因子: 5.4
• 作者: Kameyama, Sumika;Yoshimura, Yoshitaka;Iida, Junichiro
• 通讯作者: Iida, Junichiro