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Role of the basal ganglia in modification of action and cognition signals by motivation

基底神经节在动机改变行动和认知信号中的作用

基本信息

批准号：
14380377
负责人：
KIMURA Minoru
金额：
$ 9.47万
依托单位：
Kyoto Prefectural University of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

项目摘要

We conducted the following two core projects supported by the grant for the three-year term from 2002 to 2004.Project 1: Identification of neuronal information encoded by the midbrain dopamine neuronsWe recorded activity of single midbrain dopamine neurons of monkeys performing decision-making and action selection task under different reward probabilities. We found that activity of dopamine neurons code both reward expectation error and motivation signals. The coding of reward expectation error will help modification of action and cognition signals in the target structures, the striatum limbic system and cerebral frontal cortex. On the other hand, coding of motivation will work as an incentive to work for a reward. This process will motivate subjects toward their goals. The motivation coding will be used to control the gain of coding reward expectation errors in such a way that larger amount of dopamine delivery to encode an error when subjects are motivated, while smaller amount of dopamine delivery when less motivated.Project 2: Coding of motivation and value in the striatumIn order to understand representation of information in the striatum of action, contexts of reward and aversion and reward expectation, we recorded single neuron activity of the striatum of monkeys performing behavioral tasks. We found that, for the representation of action, striatal neurons code signals required for goal-directed assembling of action-related information, such as combination and sequence of movement rather than control parameters of movement, such as direction, velocity and size of movement. We found that striatal neurons detect and discriminate motivational contexts for an action, such as reward and aversion. We also found by functional imaging study of human brain that the striatum especially the caudate nucleus is involved in reward-based action selection learning.

我们在2002年至2004年的三年期限内开展了以下两个核心项目。项目1：中脑多巴胺神经元编码的神经元信息的识别我们记录了猴子在不同奖励概率下执行决策和动作选择任务的单个中脑多巴胺神经元的活动。我们发现多巴胺神经元的活动编码奖励期望误差和动机信号。奖励期望误差的编码将有助于修改目标结构、纹状体边缘系统和大脑额叶皮层中的动作和认知信号。另一方面，动机编码将作为为奖励而工作的激励。这个过程将激励受试者实现他们的目标。动机编码将用于控制编码奖励期望错误的增益，当受试者受到激励时，将大量多巴胺递送来编码错误，而当受试者动机较低时，将更少量的多巴胺递送编码错误。项目2：纹状体中动机和价值的编码为了理解纹状体中行动、奖励和厌恶的背景以及奖励期望的信息表示，我们记录了纹状体的单个神经元活动猴子执行行为任务。我们发现，为了表示动作，纹状体神经元编码目标定向组装动作相关信息所需的信号，例如运动的组合和顺序，而不是控制运动参数，例如运动的方向、速度和大小。我们发现纹状体神经元可以检测并区分行为的动机背景，例如奖励和厌恶。我们还通过对人脑的功能成像研究发现，纹状体尤其是尾状核参与基于奖励的动作选择学习。