Signal transduction regulated by MAP kinase cascades

MAP 激酶级联调节的信号转导

基本信息

  • 批准号:
    15370075
  • 负责人:
  • 金额:
    $ 9.79万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 财政年份:
    2003
  • 资助国家:
    日本
  • 起止时间:
    2003 至 2004
  • 项目状态:
    已结题

项目摘要

(1)Mitogen-activated protein kinase(MAPK) cascades can be inactivated at the MAPK activation step by members of the MAPK phosphatase(MKP) family. The Caenorhabditis elegans vhp-1 gene encodes an MKP that acts preferentially on the JNK and p38 MAPKs. VHP-1 negatively regulates a JNK-like MAPK pathway composed of MLK-1 (MAPKKK), MEK-1 (MAPKK) and KGB-1 (JNK-like MAPK) that is involved in a stress response to heavy metals. These results suggest that VHP-1 plays a pivotal role in the integration and fine-tuning of the stress response regulated by the KGB-1 MAPK pathway.(2)Kinesin-1 is a heterotetramer composed of kinesin heavy chain(KHC) and kinesin light chain(KLC). The C.elegans genome has a single KHC, encoded by unc-116 gene, and two KLCs, encoded by the klc-1 and klc-2 genes. We show here that UNC-116/KHC and KLC-2 form a complex orthologous to conventional kinesin-1. KLC-2 also binds UNC-16,the C.elegans JIP3/JSAP1 JNK-signaling scaffold protein, and the UNC-14 RUN domain protein. KLC-2 and UNC-16 co-localize in neuronal cells. The localization of UNC-16 and UNC-14 depends on kinesin-1 (UNC-116 and KLC-2). Furthermore, mutations in unc-16,klc-2,unc-116, and unc-14 all alter the localization of cargos containing synaptic vesicle markers. Double mutant analysis is consistent with these four genes functioning in the same pathway. Our data support a model whereby UNC-16 and UNC-14 function together as kinesin-1 cargos and regulators for the transport or localization of synaptic vesicle components.
(1)丝裂原活化蛋白激酶(MAPK)级联可被MAPK磷酸酶(MKP)家族成员在MAPK激活步骤中失活。秀丽隐杆线虫vhp-1基因编码的MKP优先作用于JNK和p38 MAPKs。VHP-1负调控由MLK-1 (MAPKKK)、MEK-1 (MAPKK)和KGB-1 (JNK-like MAPK)组成的jnk样MAPK通路,该通路参与重金属胁迫反应。这些结果表明,VHP-1在整合和微调由KGB-1 MAPK通路调节的应激反应中起着关键作用。(2) kinesin -1是由kinesin重链(KHC)和kinesin轻链(KLC)组成的异四聚体。秀丽隐杆线虫基因组有一个由unc-116基因编码的KHC和两个由klc-1和klc-2基因编码的klc。我们在这里发现UNC-116/KHC和KLC-2形成一个与传统的激酶-1同源的复合体。KLC-2还结合UNC-16、秀丽隐杆线虫jp3 /JSAP1 jnk信号支架蛋白和UNC-14 RUN结构域蛋白。KLC-2和UNC-16在神经元细胞中共定位。UNC-16和UNC-14的定位依赖于激酶1 (UNC-116和KLC-2)。此外,unc-16、klc-2、unc-116和unc-14的突变都改变了含有突触囊泡标记物的货物的定位。双突变分析与这四个基因在同一途径中起作用是一致的。我们的数据支持一个模型,即UNC-16和UNC-14共同作为驱动蛋白-1的货物和调节突触囊泡成分的运输或定位。

项目成果

期刊论文数量(24)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Inhibition of adipogenesis by cytokines with suppression of PPARγ function through the TAK1/TAB1-NLK mediated cascade.
通过 TAK1/TAB1-NLK 介导的级联抑制 PPARγ 功能,细胞因子抑制脂肪生成。
  • DOI:
  • 发表时间:
    2003
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Suzawa;M.;et al.
  • 通讯作者:
    et al.
Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK
  • DOI:
    10.1101/gad.1170604
  • 发表时间:
    2004-04-01
  • 期刊:
  • 影响因子:
    10.5
  • 作者:
    Kanei-Ishii, C;Ninomiya-Tsuji, J;Ishii, S
  • 通讯作者:
    Ishii, S
The TAK1-NLK MAPK cascade functions in the Wnt-5a/Ca^<2+> pathway to antagonize Wnt/β-catenin signalling.
TAK1-NLK MAPK级联在Wnt-5a/Ca ^ 2+ 途径中起作用以拮抗Wnt/β-连环蛋白信号传导。
  • DOI:
  • 发表时间:
    2003
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Ishitani;T.;et al.
  • 通讯作者:
    et al.
The TAK1-NLK MAPK cascade functions in the Wnt-5a/Ca^<2+> pathway to antagonize Wnt/b-catenin signalling.
TAK1-NLK MAPK级联在Wnt-5a/Ca ^ 2 途径中起作用以拮抗Wnt/b-联蛋白信号传导。
  • DOI:
  • 发表时间:
    2003
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Ishitani;T.;et al.
  • 通讯作者:
    et al.
Regulation of LEF-1/TCF transcription factors by MAP kinase-related NLK-dependent phosphorylation in Wnt/b-catenin signalling.
Wnt/b-连环蛋白信号传导中 MAP 激酶相关的 NLK 依赖性磷酸化对 LEF-1/TCF 转录因子的调节。
  • DOI:
  • 发表时间:
    2003
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Ishitani;T.;et al.
  • 通讯作者:
    et al.
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MATSUMOTO Kunihiro其他文献

MATSUMOTO Kunihiro的其他文献

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{{ truncateString('MATSUMOTO Kunihiro', 18)}}的其他基金

Identification and functional characterization of anandamide receptors in Caenorhabditis elegans as a model organism.
作为模式生物的秀丽隐杆线虫中 anandamide 受体的鉴定和功能表征。
  • 批准号:
    24657001
  • 财政年份:
    2012
  • 资助金额:
    $ 9.79万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Mechanism of signal transduction regulating axon regeneration
信号转导调控轴突再生的机制
  • 批准号:
    24247025
  • 财政年份:
    2012
  • 资助金额:
    $ 9.79万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
Spatio-temporal regulation of cellular trafficking and signal transduction
细胞运输和信号转导的时空调节
  • 批准号:
    21247031
  • 财政年份:
    2009
  • 资助金额:
    $ 9.79万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
Signal transduction networks regulated by MAP kinase cascades
MAP 激酶级联调节的信号转导网络
  • 批准号:
    17207012
  • 财政年份:
    2005
  • 资助金额:
    $ 9.79万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
Regulatory mechanism of cell growth and differentiation by genes related to cancers
癌症相关基因对细胞生长和分化的调控机制
  • 批准号:
    12219207
  • 财政年份:
    2000
  • 资助金额:
    $ 9.79万
  • 项目类别:
    Grant-in-Aid for Scientific Research on Priority Areas

相似海外基金

Hyphal adhesion and sexual development via cell wall polysaccharide controlled by MAP kinase cascades
MAP 激酶级联控制的细胞壁多糖的菌丝粘附和性发育
  • 批准号:
    26292037
  • 财政年份:
    2014
  • 资助金额:
    $ 9.79万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Interactions and Dual Phosphorylation in MAP Kinase Cascades
MAP 激酶级联中的相互作用和双重磷酸化
  • 批准号:
    8000154
  • 财政年份:
    2010
  • 资助金额:
    $ 9.79万
  • 项目类别:
Role of MAP kinase cascades in the regulation of diverse cellular functions
MAP 激酶级联在调节多种细胞功能中的作用
  • 批准号:
    17390020
  • 财政年份:
    2005
  • 资助金额:
    $ 9.79万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Signal transduction networks regulated by MAP kinase cascades
MAP 激酶级联调节的信号转导网络
  • 批准号:
    17207012
  • 财政年份:
    2005
  • 资助金额:
    $ 9.79万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
CAREER: Using Systems Biology to Study MAP Kinase Cascades in Arabidopsis
职业:利用系统生物学研究拟南芥中的 MAP 激酶级联
  • 批准号:
    0447750
  • 财政年份:
    2005
  • 资助金额:
    $ 9.79万
  • 项目类别:
    Continuing Grant
Functional analysis of MAP kinase cascades in plant immunity response (B01)
植物免疫反应中MAP激酶级联的功能分析(B01)
  • 批准号:
    5447891
  • 财政年份:
    2005
  • 资助金额:
    $ 9.79万
  • 项目类别:
    Collaborative Research Centres
Analysis of MAP kinase cascades in S. cerevisiae
酿酒酵母中 MAP 激酶级联的分析
  • 批准号:
    6871356
  • 财政年份:
    2003
  • 资助金额:
    $ 9.79万
  • 项目类别:
Characterization of Systemin-responsive MAP Kinase Cascades
Systemin 响应 MAP 激酶级联的表征
  • 批准号:
    0321453
  • 财政年份:
    2003
  • 资助金额:
    $ 9.79万
  • 项目类别:
    Continuing Grant
Analysis of MAP kinase cascades in S. cerevisiae
酿酒酵母中 MAP 激酶级联的分析
  • 批准号:
    6759697
  • 财政年份:
    2003
  • 资助金额:
    $ 9.79万
  • 项目类别:
Analysis of MAP kinase cascades in S. cerevisiae
酿酒酵母中 MAP 激酶级联的分析
  • 批准号:
    6649540
  • 财政年份:
    2003
  • 资助金额:
    $ 9.79万
  • 项目类别:
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