Signal transduction regulated by MAP kinase cascades
MAP 激酶级联调节的信号转导
基本信息
- 批准号:15370075
- 负责人:
- 金额:$ 9.79万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B)
- 财政年份:2003
- 资助国家:日本
- 起止时间:2003 至 2004
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
(1)Mitogen-activated protein kinase(MAPK) cascades can be inactivated at the MAPK activation step by members of the MAPK phosphatase(MKP) family. The Caenorhabditis elegans vhp-1 gene encodes an MKP that acts preferentially on the JNK and p38 MAPKs. VHP-1 negatively regulates a JNK-like MAPK pathway composed of MLK-1 (MAPKKK), MEK-1 (MAPKK) and KGB-1 (JNK-like MAPK) that is involved in a stress response to heavy metals. These results suggest that VHP-1 plays a pivotal role in the integration and fine-tuning of the stress response regulated by the KGB-1 MAPK pathway.(2)Kinesin-1 is a heterotetramer composed of kinesin heavy chain(KHC) and kinesin light chain(KLC). The C.elegans genome has a single KHC, encoded by unc-116 gene, and two KLCs, encoded by the klc-1 and klc-2 genes. We show here that UNC-116/KHC and KLC-2 form a complex orthologous to conventional kinesin-1. KLC-2 also binds UNC-16,the C.elegans JIP3/JSAP1 JNK-signaling scaffold protein, and the UNC-14 RUN domain protein. KLC-2 and UNC-16 co-localize in neuronal cells. The localization of UNC-16 and UNC-14 depends on kinesin-1 (UNC-116 and KLC-2). Furthermore, mutations in unc-16,klc-2,unc-116, and unc-14 all alter the localization of cargos containing synaptic vesicle markers. Double mutant analysis is consistent with these four genes functioning in the same pathway. Our data support a model whereby UNC-16 and UNC-14 function together as kinesin-1 cargos and regulators for the transport or localization of synaptic vesicle components.
(1)丝裂原活化蛋白激酶(MAPK)级联可被MAPK磷酸酶(MKP)家族成员在MAPK激活步骤中失活。秀丽隐杆线虫vhp-1基因编码的MKP优先作用于JNK和p38 MAPKs。VHP-1负调控由MLK-1 (MAPKKK)、MEK-1 (MAPKK)和KGB-1 (JNK-like MAPK)组成的jnk样MAPK通路,该通路参与重金属胁迫反应。这些结果表明,VHP-1在整合和微调由KGB-1 MAPK通路调节的应激反应中起着关键作用。(2) kinesin -1是由kinesin重链(KHC)和kinesin轻链(KLC)组成的异四聚体。秀丽隐杆线虫基因组有一个由unc-116基因编码的KHC和两个由klc-1和klc-2基因编码的klc。我们在这里发现UNC-116/KHC和KLC-2形成一个与传统的激酶-1同源的复合体。KLC-2还结合UNC-16、秀丽隐杆线虫jp3 /JSAP1 jnk信号支架蛋白和UNC-14 RUN结构域蛋白。KLC-2和UNC-16在神经元细胞中共定位。UNC-16和UNC-14的定位依赖于激酶1 (UNC-116和KLC-2)。此外,unc-16、klc-2、unc-116和unc-14的突变都改变了含有突触囊泡标记物的货物的定位。双突变分析与这四个基因在同一途径中起作用是一致的。我们的数据支持一个模型,即UNC-16和UNC-14共同作为驱动蛋白-1的货物和调节突触囊泡成分的运输或定位。
项目成果
期刊论文数量(24)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Inhibition of adipogenesis by cytokines with suppression of PPARγ function through the TAK1/TAB1-NLK mediated cascade.
通过 TAK1/TAB1-NLK 介导的级联抑制 PPARγ 功能,细胞因子抑制脂肪生成。
- DOI:
- 发表时间:2003
- 期刊:
- 影响因子:0
- 作者:Suzawa;M.;et al.
- 通讯作者:et al.
Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK
- DOI:10.1101/gad.1170604
- 发表时间:2004-04-01
- 期刊:
- 影响因子:10.5
- 作者:Kanei-Ishii, C;Ninomiya-Tsuji, J;Ishii, S
- 通讯作者:Ishii, S
The TAK1-NLK MAPK cascade functions in the Wnt-5a/Ca^<2+> pathway to antagonize Wnt/β-catenin signalling.
TAK1-NLK MAPK级联在Wnt-5a/Ca ^ 2+ 途径中起作用以拮抗Wnt/β-连环蛋白信号传导。
- DOI:
- 发表时间:2003
- 期刊:
- 影响因子:0
- 作者:Ishitani;T.;et al.
- 通讯作者:et al.
The TAK1-NLK MAPK cascade functions in the Wnt-5a/Ca^<2+> pathway to antagonize Wnt/b-catenin signalling.
TAK1-NLK MAPK级联在Wnt-5a/Ca ^ 2 途径中起作用以拮抗Wnt/b-联蛋白信号传导。
- DOI:
- 发表时间:2003
- 期刊:
- 影响因子:0
- 作者:Ishitani;T.;et al.
- 通讯作者:et al.
Regulation of LEF-1/TCF transcription factors by MAP kinase-related NLK-dependent phosphorylation in Wnt/b-catenin signalling.
Wnt/b-连环蛋白信号传导中 MAP 激酶相关的 NLK 依赖性磷酸化对 LEF-1/TCF 转录因子的调节。
- DOI:
- 发表时间:2003
- 期刊:
- 影响因子:0
- 作者:Ishitani;T.;et al.
- 通讯作者:et al.
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MATSUMOTO Kunihiro其他文献
MATSUMOTO Kunihiro的其他文献
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{{ truncateString('MATSUMOTO Kunihiro', 18)}}的其他基金
Identification and functional characterization of anandamide receptors in Caenorhabditis elegans as a model organism.
作为模式生物的秀丽隐杆线虫中 anandamide 受体的鉴定和功能表征。
- 批准号:
24657001 - 财政年份:2012
- 资助金额:
$ 9.79万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Mechanism of signal transduction regulating axon regeneration
信号转导调控轴突再生的机制
- 批准号:
24247025 - 财政年份:2012
- 资助金额:
$ 9.79万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Spatio-temporal regulation of cellular trafficking and signal transduction
细胞运输和信号转导的时空调节
- 批准号:
21247031 - 财政年份:2009
- 资助金额:
$ 9.79万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Signal transduction networks regulated by MAP kinase cascades
MAP 激酶级联调节的信号转导网络
- 批准号:
17207012 - 财政年份:2005
- 资助金额:
$ 9.79万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Regulatory mechanism of cell growth and differentiation by genes related to cancers
癌症相关基因对细胞生长和分化的调控机制
- 批准号:
12219207 - 财政年份:2000
- 资助金额:
$ 9.79万 - 项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
相似海外基金
Hyphal adhesion and sexual development via cell wall polysaccharide controlled by MAP kinase cascades
MAP 激酶级联控制的细胞壁多糖的菌丝粘附和性发育
- 批准号:
26292037 - 财政年份:2014
- 资助金额:
$ 9.79万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Interactions and Dual Phosphorylation in MAP Kinase Cascades
MAP 激酶级联中的相互作用和双重磷酸化
- 批准号:
8000154 - 财政年份:2010
- 资助金额:
$ 9.79万 - 项目类别:
Role of MAP kinase cascades in the regulation of diverse cellular functions
MAP 激酶级联在调节多种细胞功能中的作用
- 批准号:
17390020 - 财政年份:2005
- 资助金额:
$ 9.79万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Signal transduction networks regulated by MAP kinase cascades
MAP 激酶级联调节的信号转导网络
- 批准号:
17207012 - 财政年份:2005
- 资助金额:
$ 9.79万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
CAREER: Using Systems Biology to Study MAP Kinase Cascades in Arabidopsis
职业:利用系统生物学研究拟南芥中的 MAP 激酶级联
- 批准号:
0447750 - 财政年份:2005
- 资助金额:
$ 9.79万 - 项目类别:
Continuing Grant
Functional analysis of MAP kinase cascades in plant immunity response (B01)
植物免疫反应中MAP激酶级联的功能分析(B01)
- 批准号:
5447891 - 财政年份:2005
- 资助金额:
$ 9.79万 - 项目类别:
Collaborative Research Centres
Analysis of MAP kinase cascades in S. cerevisiae
酿酒酵母中 MAP 激酶级联的分析
- 批准号:
6871356 - 财政年份:2003
- 资助金额:
$ 9.79万 - 项目类别:
Characterization of Systemin-responsive MAP Kinase Cascades
Systemin 响应 MAP 激酶级联的表征
- 批准号:
0321453 - 财政年份:2003
- 资助金额:
$ 9.79万 - 项目类别:
Continuing Grant
Analysis of MAP kinase cascades in S. cerevisiae
酿酒酵母中 MAP 激酶级联的分析
- 批准号:
6759697 - 财政年份:2003
- 资助金额:
$ 9.79万 - 项目类别:
Analysis of MAP kinase cascades in S. cerevisiae
酿酒酵母中 MAP 激酶级联的分析
- 批准号:
6649540 - 财政年份:2003
- 资助金额:
$ 9.79万 - 项目类别: