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Application of shock waves as treatment modality in the vicinity of the brain and skull.

应用冲击波作为大脑和头骨附近的治疗方式。

基本信息

批准号：
15390428
负责人：
TAKAYAMA Kazuyoshi
金额：
$ 9.22万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15390428/
关键词：
shock wave medical care Ho : YAG laser neurosurger distortion head wound shock absorber medical engineering cavitation Ho : YAGレーザーレーザー医学頭蓋骨欠損レーザー誘発衝撃波衝撃波工学神経内視鏡低侵襲治療

项目摘要

Cranial deficits secondary to trauma, surgery, infection, or congenital malformation sometimes require cranioplasty to re-establish rigid protections for the underlying brain and to improve cosmetic appearance. Current methods for cranioplasty are mainly based on the concept of"replacing the skull defect", either with or without the aid of foreign bodies. However, problems arise from use of foreign matter and invasiveness, a novel method for cranioplasty not reliant on the use of foreign body with minimal invasion should be developed.For last two decades, shock waves have been applied, not only for the non-invasive fragmentation of stones at various locations, but also for the fragmentation of artificial bone cement in the hip arthroplasty, and pain management in calcified tendenopathies, attracting attention as a minimally invasive alternative modality. Recently, it has been clinically applied to the treatment of delayed union and non-union of long bones to induce bone formation. This … More has encouraged us to explore the potential of shock waves for closing skull defects less invasively without using foreign material. However, to apply shock waves in the vicinity of brain, there were two major problems to be solved ; one concerning the lack of a suitable shock wave source that can limit shock wave distribution around the target, and the other is the lack of a method for avoiding shock wave propagation beyond the target to ensure safe treatment. In our present study, we have solved both of those problems by developing a compact shock wave generator and brain protection method using Gore-Tex&rreg ; dura substitute. The shock waves were delivered via a holmium yttrium-aluminum-garnet laser-induced cavitational shock wave generator, which was especially designed for use in the vicinity of brain and skull, with an overpressure of 50 bar, at a rate of 3 Hz. We have applied those techniques to see whether they are effective in the closure of a bone defect in the skull of young rats, and present our preliminary results. Present results show the possibility of applying shock wave as an alternative for cranioplasty without using foreign bodies. The result of present study will also be useful for understanding of interaction between neuron and shock waves, and other application, such as shock wave orientated drug delivery system in central nervous system. Less

外伤、手术、感染或先天性畸形导致的颅骨缺损有时需要颅骨成形术来重建对底层大脑的刚性保护，并改善外观。目前的颅骨成形术主要是基于“置换颅骨缺损”的概念，或借助异物，或不借助异物。然而，由于异物的使用和侵入性带来的问题，需要开发一种不依赖于异物的微创颅骨成形术。在过去的二十年里，冲击波不仅被应用于不同部位的非侵入性结石碎裂，而且还被应用于人工骨水泥在髋关节置换术中的碎裂，以及钙化倾向病变的疼痛管理，作为一种微创替代方式引起了人们的关注。近年来，它已被临床应用于治疗长骨延迟愈合和不愈合，以诱导骨形成。这一发现鼓励我们探索冲击波在不使用异物的情况下微创缝合颅骨缺损的潜力。然而，要将冲击波应用于大脑附近，有两个主要问题需要解决；一个是缺乏合适的激波源来限制激波在目标周围的分布，另一个是缺乏避免激波传播到目标之外以确保安全治疗的方法。在我们目前的研究中，我们通过开发紧凑型冲击波发生器和使用gore - texg的脑保护方法解决了这两个问题；硬脑膜替代品。冲击波通过一个专为大脑和头骨附近使用的钬钇铝石榴石激光诱导空化冲击波发生器传递，其超压为50巴，速率为3赫兹。我们已经应用这些技术，看看它们是否有效地关闭幼鼠颅骨的骨缺损，并提出了我们的初步结果。目前的研究结果表明，在不使用异物的情况下应用冲击波作为颅骨成形术的替代方法是可能的。本研究结果将有助于理解神经元与激波之间的相互作用，以及其他应用，如激波定向的中枢神经系统给药系统。少

项目成果

期刊论文数量（82）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Pulsed holmium : yttrium-aluminum-garnet laser-induced liquid jet as a novel dissection device in neuroendoscopic surgery.

脉冲钬：钇铝石榴石激光诱导液体射流作为神经内窥镜手术中的新型解剖装置。

DOI：
发表时间：
2004
期刊：
Journal of Neurosurgery 101
影响因子：
0
作者：
Nakagawa A;Hirano T;Jokura;H;Uenonara H;Ohki T;Hashimoto T;Menenges V;Sato Y;Kusaka Y;Ohyama H;Saito T;Takayama;K;Shirane A;Tominaga T.
通讯作者：
Tominaga T.

On the efficiency of Gore-Tex layer for brain protection from shock wave damage in cranionlasty.

关于 Gore-Tex 层在颅骨成形术中保护大脑免受冲击波损伤的效率。