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Toe role of novel aggrecanase in rheumatoid arthritis and its diagnostic potential

Toe role of novel aggrecanase in rheumatoid arthritis and its diagnostic potential
新型蛋白聚糖酶在类风湿性关节炎中的作用及其诊断潜力
批准号：
15390459
负责人：
HIROHATA Satoshi
金额：
$9.6万
依托单位：
Okayama University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2003
资助国家：
日本
项目状态：
已结题
起止时间：
2003 至 2004
来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15390459/
关键词：
aggrecanaserheumatoid arthritismatrix metalloprotease

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中文摘要
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英文摘要
1 Expression analysis of novel aggrecanaseRNA was extracted from IL-1 b stimulated chondrosarcoma cells and chondrocytes and the aggrecanase expressions were analyzed by quantitative RT-PCR. When compared with fibroblasts, chondrosarcoma cells and chondrocytes showed higher induction of novel aggrecanase, thus indicating this novel aggrecanase is IL-1 induced specifically in cartilage cells. When chondrosarcoma cells were stimulated with IL-1b and TNFa, novel aggrecanase induced synergistically.2 Antibody against novel aggrecanaseWe raised a polyclonal antibody against novel aggrecanase, and checked its specificity by Western blotting. A novel aggrecanase was induced by IL-1b stimulation by Western blot analysis.3 KO mouseWe got hetero mice4 Signal mechanism for novel aggrecanase inductionMAP kinase inhibitor(PD98059,SB203580) were added to IL- 1b stimulated chondrosarcoma cells and the signaling pathway was determined.
期刊论文(23)
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会议论文
ADAMTS9 is inducible by IL-1beta and TNF-alpha in OUMS-27 chondrosarcoma cells and in human chondrocytes.
在 OUMS-27 软骨肉瘤细胞和人软骨细胞中，ADAMTS9 可被 IL-1β 和 TNF-α 诱导。
DOI： --
发表时间： 2005
期刊： Arthritis & Rheumatism (印刷中)
影响因子： --
作者： [Demircan K]
通讯作者： Demircan K
Dynamic induction of ADAMTS1 gene in the early phase of acute myocardial infarction
DOI： 10.1093/jb/mvh138
发表时间： 2004-10-01
期刊： JOURNAL OF BIOCHEMISTRY
影响因子： 2.7
作者： [Nakamura, K, Hirohata, S, Shiratori, Y]
通讯作者： Shiratori, Y
Lp3/Hapln3, a novel link protein that co-localizes with versican and is coordinately up-regulated by platelet-derived growth factor in arterial smooth muscle cells
DOI： 10.1016/j.matbio.2004.07.001
发表时间： 2004-08-01
期刊： MATRIX BIOLOGY
影响因子： 6.9
作者： [Ogawa, H, Oohashi, T, Ninomiya, Y]
通讯作者： Ninomiya, Y
Suppression of chondrosarcoma cells by 15-deoxy-Delta(12,14)-prostaglandin J(2) is associated with altered expression of Bax/Bcl-xL and p21.
15-脱氧-Delta(12,14)-前列腺素 J(2) 对软骨肉瘤细胞的抑制与 Bax/Bcl-xL 和 p21 表达的改变有关。
DOI： --
发表时间： 2005
期刊： Biochem Biophys Res Commun 328(2)
影响因子： --
作者： [Shen ZN]
通讯作者： Shen ZN
共 6 条
    The role of endocytosis in oateoarhthritis
    • 批准号：
      26670665
    • 项目类别：
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额：
      $2.33万
    • 财政年份：
      2014
    • 负责人：
      HIROHATA Satoshi
    • 依托单位：
      Okayama University
    Regulatory mechanism of transcriptional factors and microRNA in arthritis
    • 批准号：
      23390366
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $12.23万
    • 财政年份：
      2011
    • 负责人：
      HIROHATA Satoshi
    • 依托单位：
      Okayama University
    Aggrecanase regulation system in osteoarthritis and strategy for early diagnosis and therapy for osteoarthritis
    • 批准号：
      20390399
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $12.56万
    • 财政年份：
      2008
    • 负责人：
      HIROHATA Satoshi
    • 依托单位：
      Okayama University
    Inducible mechanism and role of novel aggrecanase in early stage of arthritis and its therapeutic application
    • 批准号：
      18390416
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $11.0万
    • 财政年份：
      2006
    • 负责人：
      HIROHATA Satoshi
    • 依托单位：
      Okayama University
    国内基金
    海外基金
    Autoimmune diseases therapies: variations on the microbiome in rheumatoid arthritis
    Molecular Interaction Reconstruction of Rheumatoid Arthritis Therapies Using Clinical Data