Establishment of long-term humoral memory against SARS-CoV-2 after vaccination versus infection (28)

疫苗接种与感染后建立针对 SARS-CoV-2 的长期体液记忆 (28)

• 批准号: 457417551
• 金额: --
• 依托单位: Virologisches Institut - Klinische und Molekulare Virologie
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2020
• 资助国家: 德国
• 起止时间: 2019-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/457417551?language=en
• 关键词: Establishment; long; term; humoral; memory

Currently, there are almost no data available about long-term B cell memory after infection with SARS-CoV-2 or other coronaviruses via the respiratory tract. Therefore, our long-term goal is to understand in detail the induction of a humoral memory response during natural SARS-CoV-2 infection and compare the response with that induced by different vaccination protocols. These studies will provide a clearer picture of how protective long-lived humoral immunity against SARS-CoV-2 is induced and whether B cell responses differ between a single infection and various vaccine protocols. This knowledge might be extrapolated to other respiratory coronaviruses and help to establish vaccination protocols for a future pandemic by SARS virus variants or other zoonotic respiratory pathogens.

目前，几乎没有关于通过呼吸道感染SARS-CoV-2或其他冠状病毒后长期B细胞记忆的数据。因此，我们的长期目标是详细了解自然SARS-CoV-2感染过程中诱导的体液记忆反应，并将其与不同疫苗接种方案诱导的反应进行比较。这些研究将提供一个更清晰的画面，如何保护性的长期体液免疫对SARS-CoV-2的诱导和B细胞反应是否不同之间的单一感染和各种疫苗协议。这一知识可能会外推到其他呼吸道冠状病毒，并有助于建立疫苗接种协议，为未来的大流行的SARS病毒变种或其他人畜共患呼吸道病原体。