Establishment of long-term humoral memory against SARS-CoV-2 after vaccination versus infection (28)

目前，几乎没有关于通过呼吸道感染SARS-CoV-2或其他冠状病毒后B细胞长期记忆的数据。因此，我们的长期目标是详细了解自然感染SARS-CoV-2过程中体液记忆反应的诱导，并将其与不同疫苗接种方案诱导的反应进行比较。这些研究将提供更清晰的图景，说明针对SARS-CoV-2的保护性长寿体液免疫是如何诱导的，以及单一感染和不同疫苗方案之间的B细胞反应是否不同。这一知识可能会外推到其他呼吸道冠状病毒，并有助于为未来由SARS病毒变种或其他人畜共患呼吸道病原体大流行建立疫苗接种方案。

Currently, there are almost no data available about long-term B cell memory after infection with SARS-CoV-2 or other coronaviruses via the respiratory tract. Therefore, our long-term goal is to understand in detail the induction of a humoral memory response during natural SARS-CoV-2 infection and compare the response with that induced by different vaccination protocols. These studies will provide a clearer picture of how protective long-lived humoral immunity against SARS-CoV-2 is induced and whether B cell responses differ between a single infection and various vaccine protocols. This knowledge might be extrapolated to other respiratory coronaviruses and help to establish vaccination protocols for a future pandemic by SARS virus variants or other zoonotic respiratory pathogens.