Electrochemical nanostructuring of surfaces of bulk metallic glasses on Ti-Cu basis for improvement of their biocompatibility

Ti-Cu基大块金属玻璃表面的电化学纳米结构可提高其生物相容性

• 批准号: 458057521
• 负责人: Dr. Annett Gebert
• 金额: --
• 依托单位: Institut für Materialchemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/458057521?language=en
• 关键词: Electrochemical; nanostructuring; surfaces; bulk; metallic

Owing to their high mechanical biofunctionality bulk metallic glasses (BMG) on Ti-Cu base are considered as prospective new materials for bone implants in the fields of dentistry and trauma surgery. However, in comparison to materials in current clinical use their biocompatibility is still insufficient. A critical aspect is their high Cu content, which can cause local corrosion phenomena and in consequence, the release of toxic species and mechanical material failure. Moreover, for those BMGs there are so far no reliable concepts for the generation of bioactive surface states which are mandatory for permanent implants. In the applied project a method for an electrochemical nanostructuring of surfaces of multicomponent Ti-Cu-based BMGs will be developed with the objective of effectively improving the biocompatibility and corrosion stability. The method is targeted on significantly reducing the concentration of alloying elements which are necessary for obtaining high glass-forming ability but which are critical with respect to biocompatibility, from near-surface regions. At the same time nanoporous, predominantly oxidic surface structures will be generated in order to improve the corrosion resistance and to stimulate the activity of bone cells. The mechanical performance of the BMGs must not be significantly affected. In the project two promising bulk glass-forming Ti-Cu alloys are subject of investigation for which the casting processes are already established at the IFW Dresden. For the nanostructuring, anodic treatments of glassy samples in halogenide-free acid solutions are primarily employed. The effects of treatment parameters on the developing surface states are fundamentally investigated and the underlying surface reaction mechanisms are described. A key aspect is the analysis of the impact of those surface states on the corrosion behaviour of the BMGs in synthetic physiological solutions. In particular the pitting corrosion susceptibility is to be reduced by the generation of tailored oxidic states. By means of cell biological studies the effect of selected surface states on the behaviour of human mesenchymal stroma cells (hBMSC) and of periodontal ligament fibroblasts will be fundamentally evaluated. Exemplarily, for one selected BMG the impact of surface nanostructuring on the mechanical properties under compression and tensile load will be assessed. In result of these studies, fundamental relations between structural and chemical particularities of the Ti-Cu-based BMGs, derivable routes for electrochemical surface nanostructuring and resulting corrosive, mechanical and cell biological properties will be described.

钛铜基块体金属玻璃(BMG)具有较高的力学性能和生物功能，在牙科和创伤外科领域被认为是一种很有前途的新型植骨材料。然而，与目前临床使用的材料相比，它们的生物相容性仍然不足。一个关键的方面是它们的高铜含量，这可能会导致局部腐蚀现象，从而释放有毒物质和机械材料失效。此外，对于这些BMG来说，到目前为止还没有可靠的概念来产生永久植入物所必需的生物活性表面状态。在应用项目中，将开发一种多组分Ti-Cu基BMG表面的电化学纳米结构方法，目的是有效地提高生物相容性和腐蚀稳定性。该方法的目标是从近表面区域显著降低合金元素的浓度，这些元素是获得高玻璃形成能力所必需的，但对于生物兼容性来说是关键的。同时，会产生以氧化性为主的纳米多孔表面结构，以提高骨细胞的耐蚀性和刺激骨细胞的活性。BMG的机械性能不得受到显著影响。在该项目中，两种很有前景的块状非晶钛铜合金被作为研究对象，其铸造工艺已经在德累斯顿IFW建立。对于纳米结构，主要采用在无卤化物的酸性溶液中对玻璃样品进行阳极处理。从根本上研究了处理参数对显影表面态的影响，并描述了潜在的表面反应机理。一个关键的方面是分析这些表面状态对BMG在合成生理溶液中的腐蚀行为的影响。具体地说，通过生成定制的氧化态来降低点蚀敏感性。通过细胞生物学研究，将从根本上评估选定的表面状态对人间充质基质细胞(HBMSC)和牙周膜成纤维细胞行为的影响。例如，对于一个选定的BMG，将评估表面纳米结构对压缩和拉伸载荷下的机械性能的影响。作为这些研究的结果，将描述钛-铜基BMG的结构和化学特性之间的基本关系，电化学表面纳米结构的衍生途径以及由此产生的腐蚀性、力学和细胞生物学性能。