Development of molecular imaging probes for measurement of mass in pancreatic islets.

如果能在早期发现胰岛和胰岛β细胞数量的减少，就有可能预防和治疗糖尿病。因此，一种用于胰岛成像的无创技术，特别是用于确定胰岛数量和胰岛β细胞数量的无创胰岛成像技术，已被用于糖尿病的预防和诊断。其中，特别需要一种能够成像胰岛的分子探针，优选胰腺β细胞成像。在胰岛细胞成像分子探针的设计中，研究了胰岛细胞中的各种靶分子，特别是胰岛细胞中特异性的功能蛋白。其中GLP-1R、GPR40和GLUT2作为靶分子正在研究中。

If a decrease in the amount of pancreatic islets and the amount of pancreatic β-cells can be detected at an early stage, there is a possibility for the prevention and treatment of diabetes. Therefore, a noninvasive technique for imaging of pancreatic islets, particularly a noninvasive technique for imaging of pancreatic islets for determining the amount of the pancreatic islets and the amount of pancreatic β-cells, has been desired for the prevention and diagnosis of diabetes. Among these, a molecular probe that enables the imaging of pancreatic islets, preferably the pancreatic β-cell imaging, has been desired in particular. In designing a molecular probe f or imaging of pancreatic β-cells, various targets molecule in pancreatic islet cells, particularly functional proteins specific in the β-cells, are being researched. Among these, GLP-1R, GPR40 and GLUT2 are being researched as a target molecule.