Development of in vivo imaging probes for measurement of cell mass in pancreatic islets.

如果能在早期发现胰岛数量和胰岛细胞数量的减少，就有可能预防和治疗糖尿病。因此，对于糖尿病的预防和诊断，需要一种无创的胰岛成像技术，特别是一种无创性的胰岛成像技术，以确定胰岛数量和胰岛细胞的数量。其中，尤其需要一种能够对胰岛进行成像的分子探针，最好是胰腺细胞成像。在设计用于胰岛细胞成像的分子探针时，正在研究胰岛细胞中的各种靶分子，特别是胰岛细胞中特有的功能蛋白。其中，GLP-1R和GPR40作为靶分子正在研究中。这些数据表明，[111In]K4-EX4和[125I]ARKM-405可以作为测量胰岛β细胞质量的SPECT示踪剂。

If a decrease in the amount of pancreatic islets and the amount of pancreatic.-cells can be detected at an early stage, there is a possibility for the prevention and treatment of diabetes. Therefore, a noninvasive technique for imaging of pancreatic islets, particularly a noninvasive technique for imaging of pancreatic islets for determining the amount of the pancreatic islets and the amount of pancreatic.-cells, has been desired for the prevention and diagnosis of diabetes. Among these, a molecular probe that enables the imaging of pancreatic islets, preferably the pancreatic.-cell imaging, has been desired in particular. In designing a molecular probe for imaging of pancreatic.-cells, various targets molecule in pancreatic islet cells, particularly functional proteins specific in the.-cells, are being researched. Among these, GLP-1R and GPR40 are being researched as a target molecule. These data suggest that[111In] K4-Ex4 and[125I] ARKM-405 can be a potential candidate as a SPECT tracer for measuringβ-cell mass in pancreatic islets.