Development of in vivo imaging probes for measurement of cell mass in pancreatic islets.

如果胰岛的数量和胰腺的数量减少。-细胞可以在早期被检测到，有预防和治疗糖尿病的可能。因此，一种用于胰岛成像的无创技术，特别是用于确定胰岛数量和胰腺数量的无创胰岛成像技术。-细胞，已被期望用于预防和诊断糖尿病。其中，一种分子探针，能够成像胰岛，优选胰腺。-细胞成像，已被特别期望。设计用于胰腺成像的分子探针。-细胞，胰岛细胞中的各种靶分子，特别是胰岛细胞中特异性的功能蛋白。-细胞，正在研究中。其中GLP-1R和GPR40作为靶分子正在研究中。这些数据表明[111In] K4-Ex4和[125I] ARKM-405可能是测量胰岛β细胞质量的SPECT示踪剂的潜在候选。

If a decrease in the amount of pancreatic islets and the amount of pancreatic.-cells can be detected at an early stage, there is a possibility for the prevention and treatment of diabetes. Therefore, a noninvasive technique for imaging of pancreatic islets, particularly a noninvasive technique for imaging of pancreatic islets for determining the amount of the pancreatic islets and the amount of pancreatic.-cells, has been desired for the prevention and diagnosis of diabetes. Among these, a molecular probe that enables the imaging of pancreatic islets, preferably the pancreatic.-cell imaging, has been desired in particular. In designing a molecular probe for imaging of pancreatic.-cells, various targets molecule in pancreatic islet cells, particularly functional proteins specific in the.-cells, are being researched. Among these, GLP-1R and GPR40 are being researched as a target molecule. These data suggest that[111In] K4-Ex4 and[125I] ARKM-405 can be a potential candidate as a SPECT tracer for measuringβ-cell mass in pancreatic islets.