Development of in vivo imaging probes for measurement of cell mass in pancreatic islets.
Development of in vivo imaging probes for measurement of cell mass in pancreatic islets.
批准号:
21659289
负责人:
SAJI Hideo
金额:
$2.11万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
如果能在早期发现胰岛数量和胰岛细胞数量的减少,就有可能预防和治疗糖尿病。因此,对于糖尿病的预防和诊断,需要一种无创的胰岛成像技术,特别是一种无创性的胰岛成像技术,以确定胰岛数量和胰岛细胞的数量。其中,尤其需要一种能够对胰岛进行成像的分子探针,最好是胰腺细胞成像。在设计用于胰岛细胞成像的分子探针时,正在研究胰岛细胞中的各种靶分子,特别是胰岛细胞中特有的功能蛋白。其中,GLP-1R和GPR40作为靶分子正在研究中。这些数据表明,[111In]K4-EX4和[125I]ARKM-405可以作为测量胰岛β细胞质量的SPECT示踪剂。
英文摘要
If a decrease in the amount of pancreatic islets and the amount of pancreatic.-cells can be detected at an early stage, there is a possibility for the prevention and treatment of diabetes. Therefore, a noninvasive technique for imaging of pancreatic islets, particularly a noninvasive technique for imaging of pancreatic islets for determining the amount of the pancreatic islets and the amount of pancreatic.-cells, has been desired for the prevention and diagnosis of diabetes. Among these, a molecular probe that enables the imaging of pancreatic islets, preferably the pancreatic.-cell imaging, has been desired in particular. In designing a molecular probe for imaging of pancreatic.-cells, various targets molecule in pancreatic islet cells, particularly functional proteins specific in the.-cells, are being researched. Among these, GLP-1R and GPR40 are being researched as a target molecule. These data suggest that[111In] K4-Ex4 and[125I] ARKM-405 can be a potential candidate as a SPECT tracer for measuringβ-cell mass in pancreatic islets.
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膵β細胞GLP-1受容体を標的とするSPECT用イメージングプローブExendin(9-39)誘導体の開発
开发针对胰腺β细胞GLP-1受体的SPECT成像探针Exendin (9-39)衍生物
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[小川祐, 木村寛之, 河嶋秀和, 豊田健太郎, 向英里, 藤本裕之, 平尾佳, 松田洋和, 小野正博, 稲垣暢也, 佐治英郎]
通讯作者:
佐治英郎
DEVELOPMENT OF THE PANCREATIC BETA-CELL IMAGING PROBE FOR PET TARGETING GLP-1 RECEPTOR
开发用于 PET 靶向 GLP-1 受体的胰腺 β 细胞成像探针
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Morikawa S, Naka S, Murakami K, et al., 小川祐]
通讯作者:
小川祐
Development of in vivo imaging agents targeting glucagon-like peptide-1 receptor (GLP-1R) in pancreatic islets
开发针对胰岛中胰高血糖素样肽-1 受体 (GLP-1R) 的体内成像剂
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Nakanishi T., Fukushi A., Kawai K., et al, 木村寛之]
通讯作者:
木村寛之
膵β細胞GLP-1受容体標的放射性プローブとしてのI-123標識Exendin-4誘導体
I-123标记的Exendin-4衍生物作为靶向胰腺β细胞GLP-1受体的放射性探针
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[小川祐, 木村寛之, 河嶋秀和, 豊田健太郎, 向英里, 藤本裕之, 平尾佳, 松田洋和, 小野正博, 稲垣暢也, 佐治英郎]
通讯作者:
佐治英郎
Effective Synthesis of 99mTc Tricarbonyl Complexes by Microwave Heating.
通过微波加热有效合成 99mTc 三羰基配合物。
DOI:
--
发表时间:
2012
期刊:
Journal of Organometallic Chemistry.
影响因子:
--
作者:
[Naoya Harada, Hiroyuki Kimura, Masahiro Ono, Daisuke Mori, Yoshiro Ohmomo, Tetsuya Kajimoto, Hidekazu Kawashima, Hideo Saji.]
通讯作者:
Hideo Saji.
共 19 条
Development of nuclear medical imaging probes targeting GSK-3beta for early diagnosis of tauopathy
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批准号:24659564
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.41万
-
财政年份:2012
-
负责人:SAJI Hideo
-
依托单位:
Development of molecular imaging probes for measurement of mass in pancreatic islets.
-
批准号:22249046
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$31.28万
-
财政年份:2010
-
负责人:SAJI Hideo
-
依托单位:
Development of probes for the systematic analysis of Alzheimer's disease : establishment of a new diagnostic imaging.
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批准号:19209041
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$31.95万
-
财政年份:2007
-
负责人:SAJI Hideo
-
依托单位:
Molecular imaging for noninvasive evaluation of atherosclerotic plaque vulnerability
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批准号:16390337
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.15万
-
财政年份:2004
-
负责人:SAJI Hideo
-
依托单位:
Development of a radioiodinated lipophilic cation as a new SPECT radiopharmaceutical for cancer diagnosis.
-
批准号:13470478
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.09万
-
财政年份:2001
-
负责人:SAJI Hideo
-
依托单位:
Development of in vivo dynamic and noninvasive imaging methodology of neurotransmission system with optically active radioligand.
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批准号:12557205
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.19万
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财政年份:2000
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负责人:SAJI Hideo
-
依托单位:
Development of optically active radioligand for biomedical imaging of neurotrasmission
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批准号:10470474
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$6.78万
-
财政年份:1998
-
负责人:SAJI Hideo
-
依托单位:
Development of quantitative autoradiographic method for assessing fuctional imaging in living brain slices.
-
批准号:09557189
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$5.76万
-
财政年份:1997
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负责人:SAJI Hideo
-
依托单位:
In vivo investigation of brain nicotine receptors using optically active radioligand
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批准号:08672474
-
项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.6万
-
财政年份:1996
-
负责人:SAJI Hideo
-
依托单位:
Development of optically active radioligand for in vivo investigation of brain nicotine receptors.
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批准号:06672142
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.34万
-
财政年份:1994
-
负责人:SAJI Hideo
-
依托单位:
海外基金