Motor learning-induced plasticity of cerebellar Purkinje neuron connectivity (A03)

运动学习诱导的小脑浦肯野神经元连接的可塑性 (A03)

• 批准号: 458628816
• 金额: --
• 依托单位: Cluster of Excellence: Cellular Stress Responses in Aging-Associated Diseases
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2021
• 资助国家: 德国
• 起止时间: 2020-12-31 至 2023-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/458628816?language=en
• 关键词: Motor; learning; induced; plasticity; cerebellar

Project A03 addresses the significance of Purkinje cell (PC) synaptic plasticity in accommodating cerebellar cortex connectivity changes underlying motor learning and coordination in a mouse model. A combination of mouse genetics, live imaging, and innovative tracing approaches will be used. Findings will be extended to mouse models suffering from disrupted cerebellar motor learning or ataxia, to disclose the underlying consequences for PC connectivity.

A03项目解决了浦肯野细胞(PC)突触可塑性在调节小脑皮层连通性变化方面的意义，这些变化是在小鼠模型中的运动学习和协调基础上的。将结合老鼠遗传学、活体成像和创新的追踪方法。这些发现将扩展到患有小脑运动学习障碍或共济失调的小鼠模型，以揭示PC连接的潜在后果。