Targeting the neurovascular niche in COVID-19

针对 COVID-19 中的神经血管生态位

• 批准号: 458698659
• 负责人: Professor Dr. Manuel A. Friese
• 金额: --
• 依托单位: Institut für Neuropathologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2021
• 资助国家: 德国
• 起止时间: 2020-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/458698659?language=en
• 关键词: Targeting; neurovascular; niche; COVID; 19

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to coronavirus disease 2019 (COVID-19) which has evolved into a global pandemic. SARS-CoV-2 primarily targets the respiratory tract, yet neurologic features are frequent in COVID-19 patients. However, the reasons why SARS-CoV-2 leads to neurologic symptoms is not well understood. Neuropathologically, COVID-19 patients show microvascular pathology in the absence of overt sings of viral encephalitis. Here we investigate neuroimmune-mediated mechanism in brains of COVID-19 patients using modern tools of morphology and transcriptional analysis with the aim to better understand the role of the neurovascular niche in the pathophysiology of COVID-19.

严重急性呼吸综合征冠状病毒2（SARS-CoV-2）导致2019冠状病毒病（COVID-19），已演变为全球大流行病。SARS-CoV-2主要针对呼吸道，但神经系统特征在COVID-19患者中很常见。然而，SARS-CoV-2导致神经系统症状的原因尚不清楚。在神经病理学上，COVID-19患者在没有明显病毒性脑炎迹象的情况下显示微血管病变。在这里，我们使用形态学和转录分析的现代工具研究了COVID-19患者大脑中的神经免疫介导机制，旨在更好地了解神经血管生态位在COVID-19病理生理学中的作用。