Targeting the neurovascular niche in COVID-19

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to coronavirus disease 2019 (COVID-19) which has evolved into a global pandemic. SARS-CoV-2 primarily targets the respiratory tract, yet neurologic features are frequent in COVID-19 patients. However, the reasons why SARS-CoV-2 leads to neurologic symptoms is not well understood. Neuropathologically, COVID-19 patients show microvascular pathology in the absence of overt sings of viral encephalitis. Here we investigate neuroimmune-mediated mechanism in brains of COVID-19 patients using modern tools of morphology and transcriptional analysis with the aim to better understand the role of the neurovascular niche in the pathophysiology of COVID-19.