Study on the mechanisms of vitamin A-storage in arctic animals
Study on the mechanisms of vitamin A-storage in arctic animals
批准号:
11694238
负责人:
SENOO Haruki
金额:
$5.63万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B).
财政年份:
1999
资助国家:
日本
项目状态:
已结题
起止时间:
1999 至 2000
中文摘要
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英文摘要
As xenobiotics may reduce the threshold of vitamin A-toxicity and both vitamin A and fatsoluble xenobiotics have a tendency to accumulate in the food chain, we have perfomied a systematic characterization of the hepatic vitamin A-storage in mammals and birds of the Svalbard archipelago and searched for sign of vitamin A-related toxicity in these animals. The top predators including polar bear, arctic fox, bearded seal and glaucous gull contained about 10-20 times more vitamin A than all other arctic animals studied as well as their genetically related continental top predators. The values are also high compared to normal human and experimental animals like mouse and rat. This massive amount of hepatic vitamin A was located in large autofluorescent lipid droplets in hepatic stellate cells. The droplets made up most of the cells' cytoplasm. The development of such an efficient vitamin A-storing mechanism in the hepatic stellate cells may have contributed to the survival of top predators in the extreme environment of the Arctic. These animals demonstrated neither sign of hypervitaminosis A nor pathological findings in the liver.Kidney total retinol, which may be used as a biomarke for vitamin A-related toxicity or excess, in polar bear and bearded seal were below 1% of their liver value, Which is in the normal range for most animals. Arctic fox and glaucous gull, however, had kidney levels of about 9 and 42% of the liver values, respectively. This increased kidney concentrations of total retinol in arctic fox and glaucous gull is most likely a sign of vitamin A-toxicity that deserved attention. This observation is alarming and has not been observed previously in free-living animals. Analysis of samples from older predators who over time may have accumulated more of vitamin A and organic pollutants may clarify whether these and other signs of vitamin Atoxicity is present in such animals.
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妹尾 春樹: "紫外線から皮膚を保護するビタミンA"蛋白質核酸酵素. 44. 1508-1509 (1999)
Haruki Seno:保护皮肤免受紫外线侵害的“维生素A”蛋白质核酸酶。44. 1508-1509 (1999)。
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妹尾春樹: "北極圏の哺乳類と鳥類の肝臓星細胞"肝類洞壁細胞研究の進歩. 11. 75-78 (1999)
Haruki Seno:“北极哺乳动物和鸟类的肝星状细胞”肝窦细胞研究进展 11. 75-78 (1999)。
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共 22 条
Structure and function of the vitamin A-storing cells in the digestive tract
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批准号:23590228
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.33万
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财政年份:2011
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负责人:SENOO Haruki
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依托单位:
A study on vitamin A storage in polar bears in Greenland.
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批准号:14406001
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.54万
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财政年份:2002
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负责人:SENOO Haruki
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依托单位:
a study on isolation and clonal expansion of the stem cell of hepatic stellate cells.
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批准号:13470001
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项目类别:Grant-in-Aid for Scientific Research (B)
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财政年份:2001
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负责人:SENOO Haruki
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依托单位:
Mechanisms of absorption, transport, and storage of vitamin A-by using rats and polar animals-
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批准号:09044251
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$4.42万
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依托单位:
Mechanisms of absorption, transport, and storge of vitamin A-by using rats and polar animals-
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批准号:08044237
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$1.34万
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财政年份:1996
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负责人:SENOO Haruki
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依托单位:
DEVELOPMENT OF THE THREE-DIMENSIONAL ARTIFICIAL LIVER USING A LONG-ACTING VITAMIN C DERIVATIVE
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.1万
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财政年份:1996
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负责人:SENOO Haruki
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国内基金
海外基金
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