Role of vertical transmission of HTLV-I on the risk for T cell malignancy

HTLV-I 垂直传播对 T 细胞恶性肿瘤风险的作用

• 批准号: 12470052
• 负责人: KANNAGI Mari
• 金额: $ 6.91万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12470052/
• 关键词: Immune torelance; Vertical infection; Virus; Infection immunity; Tumor immunity; HTLV-I; HTLV-1

The level of host immune responses against HTLV-I varies among HTLV-I-infected individuals. In the present study, we examined the effect of the routes of HTLV-I-transmission on the host anti-HTLV-I immune responses. When immune competent adult rats were inoculated with HTLV-I-infected cells, the orally infected rats were persistently infected with HTLV-I without humoral and cellular immune responses against HTLV-I, whereas all intravenously or intraperitoneally inoculated rats showed significant levels of immune responses. Similar defects of humoral and cellular immunity specific for HTLV-I were observed in offsprings from HTLV-I infected rats. These observations indicated that host anti-HTLV-I immunity can be affected by the conditions of the primary infection, especially in. This study provides an experimental evidence that vertical transmission can be a reason for low cell-mediated immunity against HTLV-I, which is considered to be one of the risk factors for adult T cell leukemia.

宿主对HTLV-I的免疫应答水平在HTLV-I感染的个体中不同。在本研究中，我们研究了HTLV-I传播途径对宿主抗HTLV-I免疫应答的影响。当免疫功能正常的成年大鼠接种HTLV-I感染的细胞，口服感染的大鼠持续感染HTLV-I没有体液和细胞免疫反应对HTLV-I，而所有静脉或腹腔内接种的大鼠显示出显着的免疫反应水平。在HTLV-I感染大鼠的后代中观察到HTLV-I特异性体液和细胞免疫的类似缺陷。这些观察结果表明，宿主的抗HTLV-Ⅰ免疫力可以受到原发感染的影响，特别是在。这项研究提供了一个实验证据，垂直传播可能是一个原因，低细胞介导的免疫对HTLV-I，这被认为是成人T细胞白血病的危险因素之一。

项目成果

T.Ohashi,S.Hanabuchi,H.Kato,H.Tateno,H.Takemura,T.Tsukahara,Y.Kova,A.Hasegawa,T.Masuda,and M.Kannagi.: "Prevention of adult T cell leukemia-like Iymphoproliferative disease in rats by adoptively transferred T cells from a donor immunized with human T cell

T.Ohashi、S.Hanabuchi、H.Kato、H.Tateno、H.Takemura、T.Tsukahara、Y.Kova、A.Hasekawa、T.Masuda 和 M.Kannagi.：“成人 T 细胞白血病的预防-

T.Ohashi, S.Hanabuchi, H.Kato, H.Tateno, F.Takemura, T.Tsukahara, Y.Koya, A.Hasegawa, T.Masuda, M.Kannagi: "Prevention of adult T cell leukemia-like lymphoproliferative disease in rats by adoptively transferred T cells from a donor immunized with human T

T.Ohashi、S.Hanabuchi、H.Kato、H.Tateno、F.Takemura、T.Tsukahara、Y.Koya、A.Hasekawa、T.Masuda、M.Kannagi：“预防成人 T 细胞白血病样淋巴增殖性疾病

神奈木真理: "ウイルス感染より見た免疫応答、HTLV-I."臨床と微生物. 27. 053-058 (2000)

Mari Kanagi：“从病毒感染的角度来看免疫反应，HTLV-I。” 27. 053-058 (2000)。

M.Kannagi, S.Hanabuchi, T.Ohashi, A.Hasegawa, T.Masuda: "Host defense Mechanisms against HTLV-I-induced T cell lymphomas in a rat model"AIDS Res. Hum. Retroviruses. 17(Suppl.1). S14 (2001)

M.Kannagi、S.Hanabuchi、T.Ohashi、A.Hasekawa、T.Masuda：“大鼠模型中针对 HTLV-I 诱导的 T 细胞淋巴瘤的宿主防御机制”AIDS Res。

S. Hanabuchi, T. Ohashi, Y. Koya, H. Kato, F. Takemura, K. Hirokawa, T. Yoshiki, H. Yagita, K. Okumura, and M. Kannagi: "Development of human T cell leukemia virus type I(HTLV-I)-transformed tumor in rats following suppression of T cell immunity by CD80 a

S. Hanabuchi、T. Ohashi、Y. Koya、H. Kato、F. Takemura、K. Hirokawa、T. Yoshiki、H. Yagita、K. Okumura 和 M. Kannagi：“人类 T 细胞白血病病毒型的开发