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Role of vertical transmission of HTLV-I on the risk for T cell malignancy

Role of vertical transmission of HTLV-I on the risk for T cell malignancy
HTLV-I 垂直传播对 T 细胞恶性肿瘤风险的作用
批准号：
12470052
负责人：
KANNAGI Mari
金额：
$6.91万
依托单位：
Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2000
资助国家：
日本
项目状态：
已结题
起止时间：
2000 至 2001
来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12470052/
关键词：
Immune torelanceVertical infectionVirusInfection immunityTumor immunityHTLV-IHTLV-1

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中文摘要
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英文摘要
The level of host immune responses against HTLV-I varies among HTLV-I-infected individuals. In the present study, we examined the effect of the routes of HTLV-I-transmission on the host anti-HTLV-I immune responses. When immune competent adult rats were inoculated with HTLV-I-infected cells, the orally infected rats were persistently infected with HTLV-I without humoral and cellular immune responses against HTLV-I, whereas all intravenously or intraperitoneally inoculated rats showed significant levels of immune responses. Similar defects of humoral and cellular immunity specific for HTLV-I were observed in offsprings from HTLV-I infected rats. These observations indicated that host anti-HTLV-I immunity can be affected by the conditions of the primary infection, especially in. This study provides an experimental evidence that vertical transmission can be a reason for low cell-mediated immunity against HTLV-I, which is considered to be one of the risk factors for adult T cell leukemia.
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会议论文
T.Ohashi,S.Hanabuchi,H.Kato,H.Tateno,H.Takemura,T.Tsukahara,Y.Kova,A.Hasegawa,T.Masuda,and M.Kannagi.: "Prevention of adult T cell leukemia-like Iymphoproliferative disease in rats by adoptively transferred T cells from a donor immunized with human T cell
T.Ohashi、S.Hanabuchi、H.Kato、H.Tateno、H.Takemura、T.Tsukahara、Y.Kova、A.Hasekawa、T.Masuda 和 M.Kannagi.：“成人 T 细胞白血病的预防-
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通讯作者：
神奈木真理: "ウイルス感染より見た免疫応答、HTLV-I."臨床と微生物. 27. 053-058 (2000)
Mari Kanagi：“从病毒感染的角度来看免疫反应，HTLV-I。” 27. 053-058 (2000)。
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T.Ohashi, S.Hanabuchi, H.Kato, H.Tateno, F.Takemura, T.Tsukahara, Y.Koya, A.Hasegawa, T.Masuda, M.Kannagi: "Prevention of adult T cell leukemia-like lymphoproliferative disease in rats by adoptively transferred T cells from a donor immunized with human T
T.Ohashi、S.Hanabuchi、H.Kato、H.Tateno、F.Takemura、T.Tsukahara、Y.Koya、A.Hasekawa、T.Masuda、M.Kannagi：“预防成人 T 细胞白血病样淋巴增殖性疾病
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M.Kannagi, S.Hanabuchi, T.Ohashi, A.Hasegawa, T.Masuda: "Host defense Mechanisms against HTLV-I-induced T cell lymphomas in a rat model"AIDS Res. Hum. Retroviruses. 17(Suppl.1). S14 (2001)
M.Kannagi、S.Hanabuchi、T.Ohashi、A.Hasekawa、T.Masuda：“大鼠模型中针对 HTLV-I 诱导的 T 细胞淋巴瘤的宿主防御机制”AIDS Res。
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共 19 条
    Host innate immune mechanisms separating inflammatory or lymphoproliferative diseases in HTLV-1 infection
    Anti-viral immuno therapeutic approaches for adult T-cell leukemia
    • 批准号：
      17013028
    • 项目类别：
      Grant-in-Aid for Scientific Research on Priority Areas
    • 资助金额：
      $31.04万
    • 财政年份：
      2005
    • 负责人：
      KANNAGI Mari
    • 依托单位：
      Tokyo Medical and Dental University
    The mechanism of immune insufficiency against retroviral tumors and its restoration
    • 批准号：
      15023217
    • 项目类别：
      Grant-in-Aid for Scientific Research on Priority Areas
    • 资助金额：
      $10.94万
    • 财政年份：
      2003
    • 负责人：
      KANNAGI Mari
    • 依托单位：
      Tokyo Medical and Dental University
    Spontaneous inhibition of HTL V-I expression in the peripheral blood